{"active_ingredient":["Active ingredients (in each tablet) Aspirin 325 mg (NSAID)* Dextromethorphan hydrobromide 10 mg Phenylephrine bitartrate 7.8 mg *nonsteroidal anti-inflammatory drug Purposes Pain reliever/fever reducer Cough suppressant Nasal decongestant"],"ask_doctor":["Ask a doctor before use if ● stomach bleeding warning applies to you ● you have a history of stomach problems, such as heartburn ● you have high blood pressure, heart disease, liver cirrhosis, or kidney disease ● you are taking a diuretic ● you have ● asthma ● thyroid disease ● diabetes ● cough with excessive phlegm (mucus) ● a breathing problem such as emphysema or chronic bronchitis ● difficulty in urination due to enlargement of the prostate gland ● persistent or chronic cough such as occurs with smoking, asthma, or emphysema ● a sodium-restricted diet"],"ask_doctor_or_pharmacist":["Ask a doctor or pharmacist before use if you are ● taking a prescription drug for ● gout ● diabetes ● arthritis ● taking sedatives or tranquilizers"],"do_not_use":["Do not use ● if you are allergic to aspirin or any other pain reliever/fever reducer ● if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. ● if you have ever had an allergic reaction to this product or any of its ingredients ● in children under 12 years of age"],"dosage_and_administration":["Directions ● adults and children 12 years and over: take 2 tablets fully dissolved in 4 oz of water at bedtime (may be taken every 4 to 6 hours). Do not exceed 8 tablets in 24 hours or as directed by a doctor. ● children under 12 years: do not use"],"effective_time":"20231023","id":"086318bd-5067-477e-e063-6294a90ab2dd","inactive_ingredient":["Inactive ingredients acesulfame potassium, anhydrous citric acid, aspartame, calcium silicate, dimethicone, docusate sodium, flavors (natural & artificial), mannitol, povidone, sodium benzoate, sodium bicarbonate"],"indications_and_usage":["Uses • temporarily relieves these symptoms due to a cold: • minor aches and pains • headache • runny nose • sinus congestion and pressure • cough • sneezing • sore throat • nasal congestion • temporarily reduces fever"],"keep_out_of_reach_of_children":["Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away."],"openfda":{"application_number":["M012"],"brand_name":["ALKA SELTZER PLUS Cold Day and Night Effervescent"],"generic_name":["ASPIRIN, DEXTROMETHORPHAN HYDROBROMIDE, PHENYLEPHRINE BITARTRATE"],"is_original_packager":[true],"manufacturer_name":["Sincronia Logistica, S.A. de C.V."],"nui":["N0000000160","N0000008836","M0001335","N0000175722","N0000175578","N0000008832"],"package_ndc":["71992-154-20"],"pharm_class_cs":["Anti-Inflammatory Agents, Non-Steroidal [CS]"],"pharm_class_epc":["Nonsteroidal Anti-inflammatory Drug [EPC]","Platelet Aggregation Inhibitor [EPC]"],"pharm_class_moa":["Cyclooxygenase Inhibitors [MoA]"],"pharm_class_pe":["Decreased Prostaglandin Production [PE]","Decreased Platelet Aggregation [PE]"],"product_ndc":["71992-154"],"product_type":["HUMAN OTC DRUG"],"route":["ORAL"],"rxcui":["1536498"],"spl_id":["086318bd-5067-477e-e063-6294a90ab2dd"],"spl_set_id":["c478df69-823a-4112-8f44-323249a9f38f"],"substance_name":["ASPIRIN","DEXTROMETHORPHAN HYDROBROMIDE","PHENYLEPHRINE BITARTRATE"],"unii":["R16CO5Y76E","9D2RTI9KYH","27O3Q5ML57"],"upc":["0016500572633"]},"other_safety_information":["Other information sodium 476 mg ● Phenylketonurics: Contains Phenylalanine 5.6 mg Per Tablet ● each tablet contains: ● store at room temperature. Avoid excessive heat."],"package_label_principal_display_panel":["Package Labeling: Outer Package Inner Package"],"purpose":["Purposes Pain reliever/fever reducer Cough suppressant Nasal decongestant"],"questions":["Questions? 1-800-986-0369"],"set_id":"c478df69-823a-4112-8f44-323249a9f38f","spl_product_data_elements":["ALKA SELTZER PLUS Cold Day and Night Effervescent ASPIRIN, DEXTROMETHORPHAN HYDROBROMIDE, PHENYLEPHRINE BITARTRATE ACESULFAME POTASSIUM ANHYDROUS CITRIC ACID ASPARTAME CALCIUM SILICATE DIMETHICONE DOCUSATE SODIUM METHYL SALICYLATE MANNITOL POVIDONE SODIUM BENZOATE SODIUM BICARBONATE ASPIRIN ASPIRIN DEXTROMETHORPHAN HYDROBROMIDE DEXTROMETHORPHAN PHENYLEPHRINE BITARTRATE PHENYLEPHRINE ASP;DAY"],"spl_unclassified_section":["Drug Facts"],"version":"4","warnings":["Warnings Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Reye’s syndrome: Aspirin may cause a severe allergic reaction which may include: Allergy alert: ● hives ● facial swelling ● asthma (wheezing) ● shock This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you Stomach bleeding warning: ● are age 60 or older ● have had stomach ulcers or bleeding problems ● take a blood thinning (anticoagulant) or steroid drug ● take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) ● have 3 or more alcoholic drinks every day while using this product ● take more or for a longer time than directed If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly. Sore throat warning: Do not use to sedate children. Do not use ● if you are allergic to aspirin or any other pain reliever/fever reducer ● if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. ● if you have ever had an allergic reaction to this product or any of its ingredients ● in children under 12 years of age Ask a doctor before use if ● stomach bleeding warning applies to you ● you have a history of stomach problems, such as heartburn ● you have high blood pressure, heart disease, liver cirrhosis, or kidney disease ● you are taking a diuretic ● you have ● asthma ● thyroid disease ● diabetes ● cough with excessive phlegm (mucus) ● a breathing problem such as emphysema or chronic bronchitis ● difficulty in urination due to enlargement of the prostate gland ● persistent or chronic cough such as occurs with smoking, asthma, or emphysema ● a sodium-restricted diet Ask a doctor or pharmacist before use if you are ● taking a prescription drug for ● gout ● diabetes ● arthritis ● taking sedatives or tranquilizers When using this product ● do not exceed recommended dosage ● may cause marked drowsiness ● avoid alcoholic drinks ● alcohol, sedatives, and tranquilizers may increase drowsiness ● be careful when driving a motor vehicle or ● may cause problems in the unborn child or complications during delivery. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away."],"when_using":["When using this product ● do not exceed recommended dosage ● may cause marked drowsiness ● avoid alcoholic drinks ● alcohol, sedatives, and tranquilizers may increase drowsiness ● be careful when driving a motor vehicle or ● may cause problems in the unborn child or complications during delivery."]}