{"ask_doctor":["Ask a Doctor before use if you have heart disease high blood pressure thyroid disease diabetes difficulty in urination due to enlargement of the prostate gland"],"ask_doctor_or_pharmacist":["Ask a doctor or pharmacist before use if you are presently taking a prescription drug for high blood pressure or depression."],"dosage_and_administration":["Directions adults: when practical, cleanse the affected area by patting or blotting with an appropriate cleansing wipe. Gently dry by patting or blotting with a tissue or a soft cloth before applying this cream. apply externally to the affected area up to 4 times daily, especially at night, in the morning or after each bowel movement children under 12 years of age: ask a doctor"],"effective_time":"20240808","id":"1f4a3c85-3976-44af-853c-4e9b5ead7ca8","inactive_ingredient":["Inactive ingredients Aloe Barbadensis Leaf, Cellulose Gum, Cetyl Alcohol, Citric Acid , Citric Acid Anhydrous, Disodium EDTA, Glyceryl Stearate SE, Methylparaben, Mineral Oil, Panthenol, Propyl Gallate, Propylene Glycol, Sodium Benzoate, Steareth-2, Steareth-21, Stearyl Alcohol, Tocopherol, Tocopheryl Acetate, Water (purified), Xanthan Gum"],"indications_and_usage":["Uses for temporary relief of pain, soreness and burning helps relieve the local itching and discomfort associated with hemorrhoids temporarily shrinks hemorrhoidal tissue temporarily provides a coating for relief of anorectal discomforts temporarily protects the inflamed irritated anorectal surface to help make bowel movements less painful"],"keep_out_of_reach_of_children":["Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"openfda":{"application_number":["M015"],"brand_name":["Up and Up Hemorrhoid MAX STRENGTH"],"generic_name":["14.4% GLYCERIN, 0.25% PHENYLEPHRINE HCL, 1% PRAMOXINE HCL, 15% PETROLATUM"],"is_original_packager":[true],"manufacturer_name":["Target Corporation"],"nui":["N0000185370","N0000175629","N0000184306","N0000185001","M0000728","M0009417"],"package_ndc":["82442-025-51"],"pharm_class_cs":["Allergens [CS]","Glycerol [CS]"],"pharm_class_epc":["Non-Standardized Chemical Allergen [EPC]"],"pharm_class_pe":["Increased Histamine Release [PE]","Cell-mediated Immunity [PE]","Increased IgG Production [PE]"],"product_ndc":["82442-025"],"product_type":["HUMAN OTC DRUG"],"route":["TOPICAL"],"rxcui":["1293649"],"spl_id":["1f4a3c85-3976-44af-853c-4e9b5ead7ca8"],"spl_set_id":["867677b5-fd1d-449e-966e-1de0b5c98afb"],"substance_name":["GLYCERIN","PHENYLEPHRINE HYDROCHLORIDE","PRAMOXINE HYDROCHLORIDE","PETROLATUM"],"unii":["PDC6A3C0OX","04JA59TNSJ","88AYB867L5","4T6H12BN9U"]},"other_safety_information":["Other information Store at controlled room temperature 20-25°C (68-77°F)"],"package_label_principal_display_panel":["Principal Display Panel Target up & up NDC 82442-025-51 Maximum Strength Hemorroidal Cream NET WT 1.8 OZ (51g) 257101_C-002262-01-073_G2_245050149_UU_TBE_OL 557100_C-002262-01-073_G2_245050149_UU_CBX_OL"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding, ask a health professional before use."],"purpose":["Purpose Protectant Vasoconstrictor Local anesthetic Protectant"],"set_id":"867677b5-fd1d-449e-966e-1de0b5c98afb","spl_product_data_elements":["Up and Up Hemorrhoid MAX STRENGTH 14.4% Glycerin, 0.25% Phenylephrine HCL, 1% Pramoxine HCL, 15% Petrolatum GLYCERIN GLYCERIN PHENYLEPHRINE HYDROCHLORIDE PHENYLEPHRINE PRAMOXINE HYDROCHLORIDE PRAMOXINE PETROLATUM PETROLATUM ALOE VERA LEAF CARBOXYMETHYLCELLULOSE SODIUM, UNSPECIFIED CETYL ALCOHOL CITRIC ACID MONOHYDRATE EDETATE DISODIUM GLYCERYL STEARATE SE METHYLPARABEN MINERAL OIL PANTHENOL PROPYL GALLATE PROPYLENE GLYCOL SODIUM BENZOATE STEARETH-2 STEARETH-21 STEARYL ALCOHOL TOCOPHEROL .ALPHA.-TOCOPHEROL ACETATE WATER XANTHAN GUM"],"spl_unclassified_section":["Drug Fact","Active ingredients Glycerin 14.4% Phenylephrine HCl 0.25% Pramoxine 1% White petrolatum 15%"],"stop_use":["Stop use and ask a doctor if bleeding occurs condition worsens or does not improve within 7 days an allergic reaction develops the symptom being treated does not subside or if redness, irritation, swelling, pain, or other symptoms develop or increase"],"version":"3","warnings":["Warnings For external use only"],"when_using":["When using this product do not exceed the recommended daily dosage unless directed by a doctor do not put into the rectum by using fingers or any mechanical device or applicator"]}