{"active_ingredient":["Active ingredients (in each effervescent tablet) Anhydrous citric acid 1000 mg Aspirin 325 mg (NSAID)* Sodium bicarbonate (heat-treated) 1916 mg *Nonsteroidal anti-inflammatory drug"],"ask_doctor":["Ask a doctor before use if Ask a doctor before use if ■ stomach bleeding warning applies to you ■ you have a history of stomach problems, such as heartburn ■ you have high blood pressure, heart disease, liver cirrhosis, or kidney disease ■ you are taking a diuretic ■ you have asthma ■ you have a sodium-restricted diet"],"ask_doctor_or_pharmacist":["Ask a doctor or pharmacist before use if you are ■ presently taking a prescription drug. Antacids may interact with certain prescription drugs. ■ taking a prescription drug for anticoagulation (thinning the blood), diabetes, gout or arthritis"],"do_not_use":["Do not use Do not use ■ if you are allergic to aspirin or any other pain reliever/fever reducer ■ if you have ever had an allergic reaction to this product or any of its ingredients."],"dosage_and_administration":["Directions ■ do not exceed recommended dosage ■ to avoid serious injury, completely dissolve tablets in 4 oz. of water before taking adults and children 12 years and over (up to 60 years of age): 2 tablets every 4 hours - do not exceed 8 tablets in 24 hours 60 years and over: 2 tablets every 4 hours - do not exceed 4 tablets in 24 hours Children under 12 years: consult a doctor"],"effective_time":"20241113","id":"26d12ab7-a1ea-fb79-e063-6394a90a81e4","inactive_ingredient":["Inactive ingredients ■ none"],"indications_and_usage":["Uses Uses for the temporary relief of ■ heartburn, acid indigestion and sour stomach when accompanied by headache or body aches and pains ■ upset stomach with headache from overindulgence in food or drink ■ headache, body aches, and pain alone"],"keep_out_of_reach_of_children":["Keep out of reach of children."],"openfda":{"application_number":["M013"],"brand_name":["Bromo Seltzer"],"generic_name":["ASPIRIN, SODIUM BICARBONATE, CITRIC ACID"],"is_original_packager":[true],"manufacturer_name":["Tower Laboratories Ltd"],"nui":["N0000175833","N0000175835","N0000175980","N0000008556","N0000175089","N0000000160","N0000008836","M0001335","N0000175722","N0000175578","N0000008832"],"package_ndc":["50201-0421-2"],"pharm_class_cs":["Anti-Inflammatory Agents, Non-Steroidal [CS]"],"pharm_class_epc":["Calculi Dissolution Agent [EPC]","Anti-coagulant [EPC]","Nonsteroidal Anti-inflammatory Drug [EPC]","Platelet Aggregation Inhibitor [EPC]"],"pharm_class_moa":["Acidifying Activity [MoA]","Calcium Chelating Activity [MoA]","Cyclooxygenase Inhibitors [MoA]"],"pharm_class_pe":["Decreased Coagulation Factor Activity [PE]","Decreased Prostaglandin Production [PE]","Decreased Platelet Aggregation [PE]"],"product_ndc":["50201-0421"],"product_type":["HUMAN OTC DRUG"],"route":["ORAL"],"rxcui":["1536675","1537012"],"spl_id":["26d12ab7-a1ea-fb79-e063-6394a90a81e4"],"spl_set_id":["8ff88ee1-e33e-4051-992f-24e2720c48ce"],"substance_name":["SODIUM BICARBONATE","ANHYDROUS CITRIC ACID","ASPIRIN"],"unii":["8MDF5V39QO","XF417D3PSL","R16CO5Y76E"],"upc":["0730637092108"]},"other_safety_information":["Other information ■ each tablet contains: sodium 524 mg ■ store at room temperature (59°-86°F)"],"overdosage":["In case of overdose, get medical help or contact a Poison Control Center right away."],"package_label_principal_display_panel":["PACKAGE LABEL.PRINCIPAL DISPLAY PANEL Bromo Pain 20"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery."],"purpose":["Purpose Anhydrous citric acid 1000 mg ................................ Antacid Aspirin 325 mg (NSAID)* ..........................................Pain reliever Sodium bicarbonate (heat-treated) 1916 mg ...........Antacid *Nonsteroidal anti-inflammatory drug"],"questions":["Serious side effects associated with the use of this product can be reported to the following address: Tower Laboratories LTD. P.O. Box 306 8 Industrial Park Rd. Centerbrook, CT 06409"],"set_id":"8ff88ee1-e33e-4051-992f-24e2720c48ce","spl_product_data_elements":["Bromo Seltzer ASPIRIN, SODIUM BICARBONATE, CITRIC ACID SODIUM BICARBONATE BICARBONATE ION ANHYDROUS CITRIC ACID ANHYDROUS CITRIC ACID ASPIRIN ASPIRIN L421"],"stop_use":["Stop use and ask a doctor if Stop use and ask a doctor if ■ you experience any of the following signs of stomach bleeding ■ feel faint ■ vomit blood ■ have bloody or black stools ■ have stomach pain that does not get better ■ an allergic reaction occurs. Seek medical help right away. ■ pain lasts for more than 10 days or gets worse ■ new symptoms occur ■ redness or swelling is present ■ ringing in the ears or loss of hearing occurs"],"version":"7","warnings":["Warnings Reye's syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an ealy sign of Reye's syndrome, a rare but serious illness. Allergy alert: Aspirin may cause a sever allergic reaction which may include: ■ hives ■ facial swelling ■ asthma (wheezing) ■ shock Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you ■ are age 60 or older ■ have had stomach ulcers or bleeding problems ■ take a blood thinning (anticoagulant) or steroid drug ■ take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) ■ have 3 or more alcoholic drinks every day while using this product ■ take more or for a longer time than directed"],"when_using":["When using this product When using this product do not take more than 8 tables (adults) and 4 tablets (60 years and over) in a 24-hour period or use the maximum dosage for more than 2 weeks, except under the advice and supervision of a physician."]}