{"adverse_reactions":["ADVERSE REACTIONS Adverse reactions include, but are not limited to urticaria; itching; edema of extremities; respiratory wheezing or asthma; dyspnea; cyanosis; tachycardia; lacrimation; marked perspiration; flushing of face, neck or upper chest; mild persistent clearing of throat; hacking cough or persistent sneezing. 1) Local Reactions A mild burning immediately after injection is expected; this usually subsides in 10-20 seconds. Prolonged pain or pain radiating up arm is usually the result of intramuscular injection, making this injection route undesirable. Subcutaneous injection is the recommended route. Small amounts of erythema and swelling at the site of injection are common. Reactions should not be considered significant unless they persist for at least 24 hours or exceed 50 mm in diameter. Larger local reactions are not only uncomfortable, but indicate the possibility of a severe systemic reaction if dosage is increased. In such cases dosage should be reduced to the last level not causing reaction and maintained for two or three treatments before cautiously increasing. Large, persistent local reactions or minor exacerbations of the patient’s allergic symptoms may be treated by local cold applications and/or use of oral antihistamines. 2) Systemic Reactions Systemic reactions range from mild exaggeration of patient’s allergic symptoms to anaphylactic reactions. 14 Very sensitive patients may show a rapid response. It cannot be overemphasized that, under certain unpredictable combinations of circumstances, anaphylactic shock is always a possibility. Fatalities are rare but can occur. 5 Other possible systemic reaction symptoms are fainting, pallor, bradycardia, hypotension, angioedema, cough, wheezing, conjunctivitis, rhinitis,and urticaria. 13, 14 Careful attention to dosage and administration limit such reactions. Allergenic extracts are highly potent to sensitive individuals and OVERDOSE could result in anaphylactic symptoms. Therefore, it is imperative that physicians administering allergenic extracts understand and prepare for treatment of severe reactions. Refer to “OVERDOSAGE” section."],"boxed_warning":["WARNINGS Allergenic extract is intended for use by, or under the guidance of, physicians who are experienced in the administration of allergenic extracts for diagnosis and/or immunotherapy and the emergency care of anaphylaxis. This extract is not directly interchangeable with other allergenic extracts. The initial dose must be based on skin testing as described in the “DOSAGE AND ADMINISTRATION” section of this insert. Patients switching from other types of extracts to Antigen Laboratories’ allergenic extracts should be started as if they were undergoing treatment for the first time. Patients being switched from one lot of extract to another from the same manufacturer should have the dose reduced by 75%. Severe systemic reactions may occur with all allergenic extracts. In certain individuals, especially in steroid-dependent/unstable asthmatics, these life-threatening reactions may result in death. Patients should be observed for at least 20 minutes following allergenic extract injections. Treatment and emergency measures, as well as personnel trained in their use, must be available in the event of a life-threatening reaction. Sensitive patients may experience severe anaphylactic reactions resulting in respiratory obstruction, shock, coma and/or death. Report serious adverse events to MedWatch, 5600 Fishers Lane, Rockville, MD 20852-9787, phone 1-800-FDA-1088. This product should not be injected intravenously. Deep subcutaneous routes have proven to be safe. See the “WARNINGS”, “PRECAUTIONS”, “ADVERSE REACTIONS” and “OVERDOSAGE” sections. Patients receiving beta-blockers may not be responsive to epinephrine or inhaled bronchodilators. Respiratory obstruction not responding to parenteral or inhaled bronchodilators may require theophylline, oxygen, intubation and the use of life support systems. Parenteral fluid and/or plasma expanders may be utilized for treatment of shock. Adrenocorticosteroids may be administered parenterally or intravenously. Refer to “WARNINGS”, “PRECAUTIONS” and “ADVERSE REACTIONS” sections below."],"clinical_pharmacology":["CLINICAL PHARMACOLOGY Studies indicate allergic individuals produce immunoglobulins of the IgE class in response to exposure to allergens. Subsequent exposure to the allergen results in a combination of allergen with IgE antibody fixed on mast cells or basophil membranes. This cross-linking results in stimulation of mast cell which leads to release and generation of pharmacologically active substances that produce immediate hypersensitivity reaction. 3 The mode of action of immunotherapy with allergenic extracts is still under investigation. Subcutaneous injections of increasing doses of allergenic extract into patients with allergic disease have been shown to result in both humoral and cellular changes including the production of allergen-specific IgG antibodies, the suppression of histamine release from target cells, decrease in circulating levels of antigen specific IgE antibody over long periods of time and suppression of peripheral blood T-lymphocyte cell responses to antigen. 10, 14, 15"],"contraindications":["CONTRAINDICATIONS Do not administer in the presence of diseases characterized by bleeding diathesis. Individuals with autoimmune disease may be at risk of exacerbating symptoms of the underlying disease, possibly due to routine immunization. Patients who have experienced a recent myocardial infarction may not be tolerant of immunotherapy. Children with nephrotic syndrome probably should not receive injections due to immunization causing exacerbation of nephrotic disease."],"description":["DESCRIPTION Antigen Laboratories’ allergenic extracts are manufactured from source material listed on the vial label. Lower concentrations (e.g. 1:50, 1:33, etc.) may be prepared either by dilution from a more concentrated stock or by direct extraction. The extract is a sterile solution containing extractables of source materials obtained from biological collecting and/or processing firms and Antigen Laboratories. All source materials are inspected by Antigen Laboratories’ technical personnel in accordance with 21 CFR 680.1 (b) (1). The route of administration for immunotherapy is subcutaneous. The routes of administration for diagnostic purposes are intradermal or prick-puncture of the skin. FOR ALLERGENIC EXTRACTS CONTAINING 50% V/V GLYCERINE AS PRESERVATIVE AND STABILIZER: INACTIVE INGREDIENTS: Sodium chloride…………………………………………………………….0.95% Sodium bicarbonate………………………………………………………..0.24% Glycerine…………………………………………………………………50% (v/v) Water for Injection…………………………………………………q.s. to volume Active allergens are described by common and scientific name on the stock concentrate container label or on last page of this circular. Food allergenic extracts may be manufactured on a weight/volume (w/v) or volume/volume (v/v) basis. Food extracts made from dried raw material are extracted at 2-10% (1:50-1:10 w/v ratio) in extracting fluid containing 50% glycerine. Slurries of juicy fruits or vegetables (prepared with a minimum amount of water for injection) are combined with an equal volume of glycerine for a ration of 1:1 volume/volume (v/v). Sodium chloride and sodium bicarbonate are added to the slurry and glycerine mixture. Fresh egg white extract is prepared by adding one part raw egg white to nine parts of extracting fluid (1:9 v/v). Antigen E is considered the most important allergen of Short Ragweed pollen and is used for the standardization of Short Ragweed allergenic extracts. Stock mixtures containing Short Ragweed are analyzed for Antigen E content by radial immunodiffusion using Center for Biologics Evaluation and Research (CBER) references and anti-serum. Antigen E content expressed as units of Antigen E per milliliter (U/ml) is printed on container label."],"dosage_and_administration":["DOSAGE AND ADMINISTRATION Refer to “STORAGE” section for proper storage condition for allergenic extract. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Some allergenic extracts naturally precipitate. Physicians undertaking immunotherapy should be concerned with patient’s degree of sensitivity. The initial dilution of allergenic extract, starting dose, and progression of dosage must be carefully determined on the basis of the patient’s history and results of skin tests. Strongly positive skin tests may be risk factors for systemic reactions. Less aggressive immunotherapy schedules may be indicated for such patients. Precaution is necessary when using extract mixture for skin testing. The diluting effect of individual components within a mixture may cause false negative reactions. Patients extremely sensitive to a common allergen in several components of a mixture may be more likely to experience a systemic reaction than when skin tested individually for each component. 9 PRICK-PUNCTURE TESTING: To identify highly sensitive individuals and as a safety precaution, it is recommended that a prick-puncture test using a drop of the extract concentrate be performed prior to initiating very dilute intradermal testing. Prick-puncture testing is performed by placing a drop of extract concentrate on the skin and puncturing the skin through the drop with a small needle such as a bifurcated vaccinating needle. The most satisfactory sites on the back for skin testing are from the posterior axillary fold to 2.5 cm from the spinal column, and from the top of the scapula to the lower rib margins. The best areas on the arms are the volar surfaces from the axilla to 2.5 or 5 cm above the wrist, skipping the anticubital space. A positive reaction is approximately 10-15 mm erythema with 2.5 mm wheal. Smaller, less conclusive reactions may be considered positive in conjunction with a definitive history of symptoms on exposure to the allergen. The more sensitive the patient the higher the probability that he/she will have symptoms related to the exposure of the offending allergen. Hence, the importance of a good patient history. Less sensitive individuals can be tested intradermally with an appropriately diluted extract. A positive control using histamine phosphate identifies patients whose skin may not react due to medications, metabolic or other reasons. A negative control (50% glycerine for prick-puncture testing) would exclude false-positive reactions due to ingredients in diluent or patients who have dermatographism. SINGLE DILUTION INTRADERMAL TESTING: The surface of the upper and lower arm is the usual location for skin testing. It is important that a new, sterile, disposable syringe and needle be used for each extract tested. Intracutaneous test dilutions, five-fold or ten-fold, may be prepared from stock concentrate using physiologic saline as a diluent. (1) Start testing with the most dilute allergenic extract concentration. (2) A volume of 0.02-0.05 ml should be injected slowly into the superficial skin layers making a small bleb (superficial wheal). (3) For patients without a history of extreme sensitivity, or a negative or weakly reactive prick-puncture test, the initial dilution for skin testing should be a dilution at least 1:12,500 w/v. This initial dilution can be prepared by diluting 1:20 to 1:50 w/v (2%-5%) extracts five-fold to 5 -4 or 1:10 w/v (10%) extracts to 5 -5 . See “Serial Dilutions Titration Test Dilutions” chart on the next page. Dilute 1:10 w/v (10%) extracts to 10 -3 if using ten-fold dilutions. (4) Sensitive patients with a positive prick-puncture test require a further dilution to at least 1:312,500 w/v. This dilution can be prepared by diluting 1:20 to 1:50 w/v (2% - 5%) extracts to 5 -6 or 1:10 w/v (10%) extracts to 5 -7 (five-fold dilutions). Ten-fold dilution to 10 -6 of a 1:10 w/v (10%) extract would be a safe starting dilution. Size of reactions are quantitated based on size of wheal and erythema. For interpretation of skin reactions, refer to chart below. If after 20 minutes no skin reaction is observed, continue testing using increasing increments of the concentration until a reaction of 5-10 mm wheal and 11-30 mm erythema is obtained, or a concentration of 5 -2 or 10 -1 has been tested. A negative control, 50% glycerine diluted with diluent to 5 -2 (1:25) or 10 -1 (1:10) dilution and a positive control of histamine phosphate, should be tested and included in interpretation of skin reactions. 1, 13 GRADE mm ERYTHEMA mm WHEAL 0 less than 5 less than 5 ± 5-10 5-10 1+ 11-20 5-10 2+ 21-30 5-10 3+ 31-40 10-15 or with pseudopods 4+ greater than 40 greater than 15 or with many pseudopods INTRADERMAL TESTING-SKIN ENDPOINT TITRATION: The allergenic extracts to which the patient is sensitive, the patient’s degree of sensitivity and the dose of allergen to be used in immunotherapy can be determined through the use of intracutaneous skin tests involving progressive five-fold dilutions of allergenic extracts. Intracutaneously inject 0.01 to 0.02 ml of the test allergen to form a 4 mm diameter superficial skin wheal. For patients demonstrating a negative or weakly reactive prick-puncture skin test, an initial screening dilution of 1:12,500 w/v is safe. For patients demonstrating a positive prick-puncture skin test, an initial screening dilution of 1:312,500 w/v is safe. (See “Serial Dilution Titration Test Dilutions” chart below.) When a sequence of five-fold or ten-fold dilutions of an allergen are injected, the endpoint is determined by noting the dilution that first produces a wheal and erythema (15 minutes after injection) that is 2 mm larger than wheals with erythema produced by weaker, non-reacting dilutions (5 mm negative wheal). The endpoint dilution is used as a starting dose concentration for immunotherapy. An endpoint dose of 0.15 ml is a safe initial dose to be followed by escalation to the optimal maximum tolerated dose for each individual. Injections should never be given intravenously. A 5/8 inch, 25 gauge needle on a sterile syringe will allow deep subcutaneous injection. IMMUNOTHERAPY: If the first injection of the initial dilution of extract is tolerated without significant local reaction, increasing doses by 5-20% increments of that dilution may be administered. The rate of increase in dosage in the early stages of treatment with highly diluted extracts is usually more rapid than the rate of increase possible with more concentrated extracts. This schedule is intended only as a guide and must be modified according to the reactivity of the individual patient. Needless to say, the physician must proceed cautiously in the treatment of the highly sensitive patient who develops large local or systemic reactions. 6 Some patients may tolerate larger doses of the allergenic extract depending on patient response. 7 Because diluted extract tends to lose activity in storage, the first dose from a more concentrated vial should be the same, or less than, the previous dose. 8, 12 Dosages progressively increase according to the tolerance of the patient at intervals of one to seven days until, (1) the patient achieves relief from symptoms, (2) induration at the site of injection is no larger than 50 mm in 36 to 48 hours, (3) a maintenance dose is reached (the largest dose tolerated by the patient that relieves symptoms without undesirable local or systemic reactions). This maintenance dose may be continued at regular intervals perennially. It may be necessary to adjust the progression of dosage downward to avoid local and constitutional reactions. The usual duration of treatment has not been established. A period of two or three years on immunotherapy constitutes an average minimum course of treatment. SERIAL DILUTION TITRATION TEST DILUTIONS APPROXIMATE ALLERGENIC EXTRACT CONCENTRATION RESULTING FROM 1:5 DILUTION Titration Number Dilution Exponent Weight / Volume Allergenic Extract Concentrate 1:50 (2%) 1:40 (2 1/2%) 1:33 1/3 (3%) 1:20 (5%) 1:10 (10%) No. 1 5 -1 1:5 1:250 1:200 1:167 1:100 1:50 No. 2 5 -2 1:25 1:1,250 1:1,000 1:835 1:500 1:250 No. 3 5 -3 1:125 1:6,250 1:5,000 1:4,175 1:2,500 1:1,250 No. 4 5 -4 1:625 1:31,250 1:25,000 1:20,875 1:12,500 1:6,250 No. 5 5 -5 1:3,125 1:156,250 1:125,000 1:104,375 1:62,500 1:31,250 No. 6 5 -6 1:15,625 1:781,250 1:625,000 1:521,875 1:312,500 1:156,250 No. 7 5 -7 1:78,125 1:3,906,250 1:3,125,000 1:2,609,375 1:1,562,500 1:781,250 No. 8 5 -8 1:390,625 1:19,531,250 1:15,625,000 1:13,046,875 1:7,812,500 1:3,906,250 No. 9 5 -9 1:1,953,125 1:97,656,250 1:78,125,000 1:65,234,375 1:39,062,500 1:19,531,250 No. 10 5 -10 1:9,765,625 1:488,281,250 1:390,625,000 1:326,171,875 1:195,312,500 1:97,656,250 No. 11 5 -11 1:48,828,125 1:2,441,406,250 1:1,953,125,000 1:1,630,859,375 1:976,562,500 1:488,281,250 No. 12 5 -12 1:244,140,625 1:12,207,031,250 1:9,765,625,000 1:8,154,296,875 1:4,882,812,500 1:2,441,406,250"],"dosage_and_administration_table":["
GRADE mm ERYTHEMA mm WHEAL
0 less than 5 less than 5
± 5-10 5-10
1+ 11-20 5-10
2+ 21-30 5-10
3+ 31-40 10-15 or with pseudopods
4+ greater than 40 greater than 15 or with many pseudopods
","
SERIAL DILUTION TITRATION TEST DILUTIONS APPROXIMATE ALLERGENIC EXTRACT CONCENTRATION RESULTING FROM 1:5 DILUTION
Titration Number Dilution Exponent Weight / Volume Allergenic Extract Concentrate
1:50 (2%) 1:40 (2 1/2%) 1:33 1/3 (3%) 1:20 (5%) 1:10 (10%)
No. 1 5-1 1:5 1:250 1:200 1:167 1:100 1:50
No. 2 5-2 1:25 1:1,250 1:1,000 1:835 1:500 1:250
No. 3 5-3 1:125 1:6,250 1:5,000 1:4,175 1:2,500 1:1,250
No. 4 5-4 1:625 1:31,250 1:25,000 1:20,875 1:12,500 1:6,250
No. 5 5-5 1:3,125 1:156,250 1:125,000 1:104,375 1:62,500 1:31,250
No. 6 5-6 1:15,625 1:781,250 1:625,000 1:521,875 1:312,500 1:156,250
No. 7 5-7 1:78,125 1:3,906,250 1:3,125,000 1:2,609,375 1:1,562,500 1:781,250
No. 8 5-8 1:390,625 1:19,531,250 1:15,625,000 1:13,046,875 1:7,812,500 1:3,906,250
No. 9 5-9 1:1,953,125 1:97,656,250 1:78,125,000 1:65,234,375 1:39,062,500 1:19,531,250
No. 10 5-10 1:9,765,625 1:488,281,250 1:390,625,000 1:326,171,875 1:195,312,500 1:97,656,250
No. 11 5-11 1:48,828,125 1:2,441,406,250 1:1,953,125,000 1:1,630,859,375 1:976,562,500 1:488,281,250
No. 12 5-12 1:244,140,625 1:12,207,031,250 1:9,765,625,000 1:8,154,296,875 1:4,882,812,500 1:2,441,406,250
"],"effective_time":"20091117","how_supplied":["HOW SUPPLIED Stock concentrates are available in concentrations of 2-10% or weight/volume (w/v) of 1:50, 1:33, 1:20 or 1:10. Some juicy or liquid foods are available at 1:1 volume/volume (v/v) extraction ratio. Fresh egg white extract is available at 1:9 v/v extraction ratio. Antigen E content of ragweed mixtures ranges from 46-166 U/ml for Ragweed Mixture (Short/Giant/Western/Southern Ragweed), 47-239 U/ml for Short/Giant/Western Ragweed Mixture, and 106-256 U/ml for Short/Giant Ragweed Mixture. Refer to container label for actual Antigen E content. Extract (stock concentrate) is supplied in 10, 30 and 50 ml containers. Extracts in 5 ml dropper bottles are available for prick-puncture testing. To insure maximum potency for the entire dating period, all stock concentrates contain 50% glycerine v/v."],"id":"272c9910-2160-4d41-afbd-faab3055ba1d","indications_and_usage":["INDICATIONS AND USAGE Allergenic extract is used for diagnostic testing and for the treatment (immunotherapy) of patients whose histories indicate that upon natural exposure to the allergen, they experience allergic symptoms. Confirmation is determined by skin testing. Diagnostic use of allergenic extracts usually begins with direct skin testing. This product is not intended for treatment of patients who do not manifest immediate hypersensitivity reactions to the allergenic extract following skin testing."],"openfda":{},"overdosage":["OVERDOSAGE Refer to “WARNINGS”, “PRECAUTIONS” and “ADVERSE REACTIONS” sections for signs and symptoms of an overdose. If a systemic or anaphylactic reaction does occur, apply tourniquet above the site of allergenic extract injection and inject intramuscularly or subcutaneously 0.3 to 0.5 ml of 1:1000 Epinephrine-hydrochloride into the opposite arm or gluteal area. Repeat dose in 5-10 minutes if necessary. Loosen tourniquet briefly at 5 minute intervals to prevent circulatory impairment. Discontinue use of the tourniquet after ½ hour. The epinephrine HCL 1:1000 dose for infants to 2 years is 0.05 to 0.1 ml; for children 2 to 6 years it is 0.15 ml; for children 6 to 12 years it is 0.2 ml. Symptoms of progressive anaphylaxis include airway obstruction and/or vascular collapse. After administration of epinephrine, profound shock and vasomotor collapse should be treated with intravenous fluids and possibly vasoactive drugs. Monitor airways for obstruction. Oxygen should be given by mask if indicated. Antihistamines, H 2 antagonist, bronchodilators, steroids and theophylline may be used as indicated after providing adequate epinephrine and circulatory support. 4 Patients who have been taking beta-blockers may be unresponsive to epinephrine. Epinephrine or beta-adrenergic drugs (Alupent) may be ineffective. These drugs should be administered even though a beta-blocker may have been taken. The following treatment will be effective whether or not patient is taking a beta-blocker: Aminophylline IV, slow push or drip, Atrovent (Ipratropium bromide) Inhaler, 3 inhalations repeated, Atropine, 0.4 mg/ml, 0.75 to 1.5 ml IM or IV, Solu-Cortef, 100-200 mg IM or IV, Solu-Medrol, 125 mg IM or IV, Glucagon, 0.5-1 mg IM or IV, Benadryl, 50 mg IM or IV, Cimetidine, 300 mg IM or IV, Oxygen via ambu bag."],"package_label_principal_display_panel":["CONTAINER LABELING 5 mL Green Label 10 mL Green Label 30/50 mL Green Label"],"precautions":["PRECAUTIONS General: Immunotherapy must be given under physician’s supervision. Sterile solutions, vials, syringes, etc. must be used. Aseptic technique must be observed in making dilutions from stock concentrates. The usual precautions in administering allergenic extracts are necessary, refer to boxed WARNINGS and “WARNINGS” section. Sterile syringe and needle must be used for each individual patient to prevent transmission of serum hepatitis, Human Immunodeficiency Virus (HIV) and other infectious agents. Epinephrine 1:1000 should be available. Refer to “OVERDOSAGE” section for description of treatment for anaphylactic reactions. Information for Patients: Patient should remain under observation of a nurse, physician, or personnel trained in emergency measures for at least 20 minutes following immunotherapy injection. Patient must be instructed to report any adverse reactions that occur within 24 hours after injection. Possible adverse reactions include unusual swelling and/or tenderness at injection site, rhinorrhea, sneezing, coughing, wheezing, shortness of breath, nausea, dizziness, or faintness. Immediate medical attention must be sought for reactions that occur during or after leaving physician’s office. Carcinogenesis, Mutagenesis, Impairment of Fertility: Long term studies in animals have not been conducted with allergenic extract to determine their potential for carcinogenicity, mutagenicity or impairment of fertility. Pregnancy Category C: Animal reproduction studies have not been conducted with allergenic extracts. It is not known whether allergenic extracts cause fetal harm during pregnancy or affect reproductive capacity. A systemic reaction to allergenic extract could cause uterine contractions leading to spontaneous abortion or premature labor. Allergenic extracts should be used during pregnancy only if potential benefit justifies potential risk to fetus. 11 Nursing Mothers: It is not known whether allergenic extracts are excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when allergenic extracts are administered to a nursing woman. Pediatric Use: Allergenic extracts have been used routinely in children, and no special safety problems or specific hazards have been found. Children can receive the same dose as adults. Discomfort is minimized by dividing the dose in half and administering injection at two different sites. 16, 17 Drug Interactions: Antihistamines. Antihistamines inhibit the wheal and flare reaction. The inhibitory effect of conventional antihistamines varies from 1 day up to 10 days, according to the drug and patient’s sensitivity. Long acting antihistamines (e.g., astemizole) may inhibit the wheal and flare for up to forty days. 1, 2 Imipramines, phenothiazines, and tranquilizers. Tricyclic antidepressants exert a potent and sustained decrease of skin reactions to histamine. This effect may last for a few weeks. Tranquilizers and antiemetic agents of the phenothiazine class have H 1 antihistaminic activity and can block skin tests. 1 Corticosteroids. Short-term (less than 1 week) administration of corticosteroids at the therapeutic doses used in asthmatic patients does not modify the cutaneous reactivity to histamine, compound 48/80, or allergen. Long-term corticosteroid therapy modifies the skin texture and makes the interpretation of immediate skin tests more difficult. 1 Theophylline. It appears that theophylline need not be stopped prior to skin testing. 1 Beta-Blockers. Patients receiving beta-blockers may not be responsive to epinephrine or inhaled bronchodilators. The following are commonly prescribed beta-blockers: Levatol, Lopressor, Propanolol Intersol, Propanolol HCL, Blocadren, Propanolol, Inderal-LA, Visken, Corgard, Ipran, Tenormin, Timoptic. Ophthalmic beta-blockers: Betaxolol, Levobunolol, Timolol, Timoptic. Chemicals that are beta-blockers and may be components of other drugs: Acebutolol, Atenolol, Esmolol, Metoprolol, Nadolol, Penbutolol, Pindolol, Propanolol, Timolol, Labetalol, Carteolol. 1 Beta-adrenergic agents. Inhaled beta 2 agonists in the usual doses used for the treatment of asthma do not usually inhibit allergen-induced skin tests. However, oral terbutaline and parenteral ephedrine were shown to decrease the allergen-induced wheal. 1 Cromolyn. Cromolyn inhaled or injected prior to skin tests with allergens or degranulating agents does not alter skin whealing response. 1 Other drugs. Other drugs have been shown to decrease skin test reactivity. Among them, dopamine is the best-documented compound. 1 Specific Immunotherapy. A decreased skin test reactivity has been observed in patients undergoing specific immunotherapy with pollen extracts, grass pollen allergoids, mites, hymenoptera venoms, or in professional beekeepers who are spontaneously desensitized. Finally, it was shown that specific immunotherapy in patients treated with ragweed pollen extract induced a decreased late-phase reaction. 1"],"references":["REFERENCES 1. Bousquet, Jean: “In vivo methods for study of allergy: Skin tests” Third Edition, Allergy Principles and Practice, C.V. Mosby Co., Vol. I, Chap. 19, pp 419-436, 1988. 2. Long, W.F., Taylor, R.J., Wagner, C.J., et al.: Skin test suppression by antihistamines and the development of subsensitivity, J. Allergy Clin. Immunol., pp. 76-113, 1985. 3. Holgate, S.T., Robinson, C., Church, Mike: Mediators of Immediate Hypersensitivity, Third Edition, Allergy Principles and Practice, C.V. Mosby Co., Vol. I and II, pp 135-163, 1988. 4. Wasserman, S., Marquart, D.: Anaphylaxis, Third Edition, Allergy Principles and Practice, C.V. Mosby Co., Vol. 1, Chap. 58, pp. 1365-1376, 1988. 5. Reid, Michael J., Lockey, Richard F., Turkeltaub M.D., Paul C., Platts-Mills, Thomas. “Survey of Fatalities from Skin Testing and Immunotherapy 1985-1989”, Journal of Allergy and Clinical Immunology, Vol. 92, No. 1, pp. 6-15, 1993. 6. Matthews, K., et al: Rhinitis, Asthma and Other Allergic Diseases. NIAID Task Force Report, U.S. Dept. HEW, NIH Publication No. 79-387, Chapter 4, pp. 213-217, May 1979. 7. Ishizaka, K.: Control of IgE Synthesis, Third Edition, Allergy Principles and Practices, Vol. I, Chap. 4, p. 52, edited by Middleton et al. 8. Nelson, H.S.: “The Effect of Preservatives and Dilution on the Deterioration of Russian Thistle (Salsola pestifer), a pollen extract.” The Journal of Allergy and Clinical Immunology, Vol. 63, No. 6, pp. 417-425, June 1979. 9. Seebohm, P.M., et al: Panel on Review of Allergenic Extracts, Final Report, Food and Drug Administration, March 13, 1981, pp. 84-86. 10. Rocklin, R.E., Sheffer, A.L., Grainader, D.K. and Melmon, K.: “Generation of antigen-specific suppressor cells during allergy desensitization”, New England Journal of Medicine, 302, May 29, 1980, pp. 1213-1219. 11. Seebohm, P.M., et al: Panel on Review of Allergenic Extracts, Final Report, Food and Drug Administration, March 13, 1981, pp 9-48. 12. Stevens, E.: Cutaneous Tests, Regulatory Control and Standardization of Allergenic Extracts, First International Paul-Ehrlich Seminar, May 20-22, 1979, Frankfurt, Germany, pp. 133-138. 13. Van Metre, T., Adkinson, N., Amodio, F., Lichtenstein, L., Mardinay, M., Norman, P., Rosenberg, G., Sobotka, A., Valentine, M.: “A Comparative Study of the Effectiveness of the Rinkel Method and the Current Standard Method of Immunology for Ragweed Pollen Hay Fever,“ The Journal of Clinical Allergy and Immunology, Vol. 66, No. 6, p. 511, December 1980. 14. Wasserman, S.: The Mast Cell and the Inflammatory Response. The Mast Cell-its role in Health and disease. Edited by J. Pepys & A.M. Edwards, Proceedings of an International Symposium, Davos, Switzerland, Pitman Medical Publishing Co., 1979, pp. 9-20. 15. Perelmutter, L.: IgE Regulation During Immunotherapy of Allergic Diseases. Annals of Allergy, Vol. 57, August 1986. 16. Bullock, J., Frick, O.: Mite Sensitivity in House Dust Allergic Children, Am. J. Dis. Child., pp. 123-222, 1972. 17. Willoughby, J.W.: Inhalant Allergy Immunotherapy with Standardized and Nonstandardized Allergenic Extracts, American Academy of Otolaryngology-Head and Neck Surgery: Instructional Courses, Vol. 1, Chapter 15, C.V. Mosby Co., St. Louis, Missouri, September 1988."],"set_id":"6d2006e2-55ea-41db-bd17-ce6d080f28a0","spl_product_data_elements":["Chaetomium Chaetomium CHAETOMIUM GLOBOSUM CHAETOMIUM GLOBOSUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Cephalosporium Cephalosporium ACREMONIUM STRICTUM ACREMONIUM STRICTUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Cladosporium herbarum Cladosporium herbarum CLADOSPORIUM HERBARUM CLADOSPORIUM HERBARUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Curvularia Curvularia COCHLIOBOLUS SPICIFER COCHLIOBOLUS SPICIFER GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Botrytis Botrytis BOTRYTIS CINEREA BOTRYTIS CINEREA GLYCERIN SODIUM BICARBONATE WATER SODIUM CHLORIDE Aspergillus niger Aspergillus niger ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS NIGER VAR. NIGER GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Cephalosporium Cephalosporium ACREMONIUM STRICTUM ACREMONIUM STRICTUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Bermuda Grass Smut Bermuda Grass Smut USTILAGO CYNODONTIS USTILAGO CYNODONTIS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Helminthosporium Helminthosporium COCHLIOBOLUS SATIVUS COCHLIOBOLUS SATIVUS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Helminthosporium Helminthosporium COCHLIOBOLUS SATIVUS COCHLIOBOLUS SATIVUS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Johnson Grass Smut Johnson Grass Smut SPORISORIUM CRUENTUM SPORISORIUM CRUENTUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Johnson Grass Smut Johnson Grass Smut SPORISORIUM CRUENTUM SPORISORIUM CRUENTUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Fusarium oxysporum Fusarium oxysporum FUSARIUM OXYSPORUM FUSARIUM OXYSPORUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Epicoccum Epicoccum EPICOCCUM NIGRUM EPICOCCUM NIGRUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Hormodendrum Hormodendrum CLADOSPORIUM CLADOSPORIOIDES CLADOSPORIUM CLADOSPORIOIDES GLYCERIN SODIUM BICARBONATE WATER SODIUM CHLORIDE Hormodendrum Hormodendrum CLADOSPORIUM CLADOSPORIOIDES CLADOSPORIUM CLADOSPORIOIDES GLYCERIN SODIUM BICARBONATE WATER SODIUM CHLORIDE Number Four Mold Mixture Number Four Mold Mixture ALTERNARIA ALTERNATA ALTERNARIA ALTERNATA ASPERGILLUS FLAVUS ASPERGILLUS FLAVUS ASPERGILLUS FUMIGATUS ASPERGILLUS FUMIGATUS ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS REPENS ASPERGILLUS REPENS CLADOSPORIUM CLADOSPORIOIDES CLADOSPORIUM CLADOSPORIOIDES PENICILLIUM CAMEMBERTI PENICILLIUM CAMEMBERTI PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM EXPANSUM PENICILLIUM EXPANSUM PENICILLIUM ITALICUM PENICILLIUM ITALICUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM ROQUEFORTI PENICILLIUM ROQUEFORTI GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Grass Smut Mixture Grass Smut Mixture USTILAGO CYNODONTIS USTILAGO CYNODONTIS SPORISORIUM CRUENTUM SPORISORIUM CRUENTUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Grain Smut Mixture Grain Smut Mixture USTILAGO NUDA HORDEI USTILAGO NUDA HORDEI USTILAGO MAYDIS USTILAGO MAYDIS USTILAGO AVENAE USTILAGO AVENAE USTILAGO TRITICI USTILAGO TRITICI GLYCERIN SODIUM BICARBONATE SODIUM CHLORIDE WATER A Mold Mixture A Mold Mixture ASPERGILLUS FLAVUS ASPERGILLUS FLAVUS ASPERGILLUS FUMIGATUS ASPERGILLUS FUMIGATUS ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS REPENS ASPERGILLUS REPENS BOTRYTIS CINEREA BOTRYTIS CINEREA CHAETOMIUM GLOBOSUM CHAETOMIUM GLOBOSUM EPICOCCUM NIGRUM EPICOCCUM NIGRUM FUSARIUM OXYSPORUM FUSARIUM OXYSPORUM GEOTRICHUM CANDIDUM GEOTRICHUM CANDIDUM COCHLIOBOLUS SATIVUS COCHLIOBOLUS SATIVUS CANDIDA TROPICALIS CANDIDA TROPICALIS NEUROSPORA INTERMEDIA NEUROSPORA INTERMEDIA MUCOR PLUMBEUS MUCOR PLUMBEUS MUCOR RACEMOSUS MUCOR RACEMOSUS PENICILLIUM CAMEMBERTI PENICILLIUM CAMEMBERTI PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM EXPANSUM PENICILLIUM EXPANSUM PENICILLIUM ITALICUM PENICILLIUM ITALICUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM ROQUEFORTI PENICILLIUM ROQUEFORTI PHOMA DESTRUCTIVA PHOMA DESTRUCTIVA AUREOBASIDIUM PULLULANS VAR. PULLUTANS AUREOBASIDIUM PULLULANS VAR. PULLUTANS RHIZOPUS STOLONIFER RHIZOPUS STOLONIFER RHODOTORULA RUBRA RHODOTORULA RUBRA SACCHAROMYCES CEREVISIAE SACCHAROMYCES CEREVISIAE RHIZOPUS STOLONIFER RHIZOPUS STOLONIFER GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Microsporum canis Microsporum canis MICROSPORUM CANIS MICROSPORUM CANIS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER B Mold Mixture B Mold Mixture TRICHOTHECIUM ROSEUM TRICHOTHECIUM ROSEUM PASSALORA FULVA PASSALORA FULVA COCHLIOBOLUS SPICIFER COCHLIOBOLUS SPICIFER MYROTHECIUM VERRUCARIA MYROTHECIUM VERRUCARIA HYPOMYCES PERNICIOSUS HYPOMYCES PERNICIOSUS NEUROSPORA CRASSA NEUROSPORA CRASSA KHUSKIA ORYZAE KHUSKIA ORYZAE PAECILOMYCES VARIOTII PAECILOMYCES VARIOTII MICROASCUS BREVICAULIS MICROASCUS BREVICAULIS COLLETOTRICHUM COCCODES COLLETOTRICHUM COCCODES PLEOSPORA HERBARUM PLEOSPORA HERBARUM STREPTOMYCES GRISEUS STREPTOMYCES GRISEUS TRICHODERMA VIRIDE TRICHODERMA VIRIDE TRICHOPHYTON SCHOENLEINII TRICHOPHYTON SCHOENLEINII GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Aspergillus Mixture Aspergillus Mixture ASPERGILLUS FLAVUS ASPERGILLUS FLAVUS ASPERGILLUS FUMIGATUS ASPERGILLUS FUMIGATUS ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS REPENS ASPERGILLUS REPENS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Alternaria alternata Alternaria alternata ALTERNARIA ALTERNATA ALTERNARIA ALTERNATA GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Number Ten Mold Mixture Number Ten Mold Mixture ALTERNARIA ALTERNATA ALTERNARIA ALTERNATA ASPERGILLUS FLAVUS ASPERGILLUS FLAVUS ASPERGILLUS FUMIGATUS ASPERGILLUS FUMIGATUS ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS REPENS ASPERGILLUS REPENS FUSARIUM OXYSPORUM FUSARIUM OXYSPORUM COCHLIOBOLUS SATIVUS COCHLIOBOLUS SATIVUS CLADOSPORIUM CLADOSPORIOIDES CLADOSPORIUM CLADOSPORIOIDES MUCOR RACEMOSUS MUCOR RACEMOSUS PENICILLIUM CAMEMBERTI PENICILLIUM CAMEMBERTI PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM EXPANSUM PENICILLIUM EXPANSUM PENICILLIUM ITALICUM PENICILLIUM ITALICUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM ROQUEFORTI PENICILLIUM ROQUEFORTI PHOMA DESTRUCTIVA PHOMA DESTRUCTIVA AUREOBASIDIUM PULLULANS VAR. PULLUTANS AUREOBASIDIUM PULLULANS VAR. PULLUTANS RHIZOPUS STOLONIFER RHIZOPUS STOLONIFER GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Aspergillus fumigatus Aspergillus fumigatus ASPERGILLUS FUMIGATUS ASPERGILLUS FUMIGATUS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Alternaria alternata Alternaria alternata ALTERNARIA ALTERNATA ALTERNARIA ALTERNATA GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Mucor Mixture Mucor Mixture MUCOR PLUMBEUS MUCOR PLUMBEUS MUCOR RACEMOSUS MUCOR RACEMOSUS RHIZOPUS STOLONIFER RHIZOPUS STOLONIFER GLYCERIN SODIUM BICARBONATE WATER SODIUM CHLORIDE Monilia Mixture Monilia Mixture CANDIDA TROPICALIS CANDIDA TROPICALIS NEUROSPORA INTERMEDIA NEUROSPORA INTERMEDIA GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Trichophyton Mixture Trichophyton Mixture TRICHOPHYTON MENTAGROPHYTES TRICHOPHYTON MENTAGROPHYTES TRICHOPHYTON RUBRUM TRICHOPHYTON RUBRUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Penicillium Mixture Penicillium Mixture PENICILLIUM CAMEMBERTI PENICILLIUM CAMEMBERTI PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM EXPANSUM PENICILLIUM EXPANSUM PENICILLIUM ITALICUM PENICILLIUM ITALICUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM ROQUEFORTI PENICILLIUM ROQUEFORTI GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Grain Smut Mixture Grain Smut Mixture USTILAGO NUDA HORDEI USTILAGO NUDA HORDEI USTILAGO MAYDIS USTILAGO MAYDIS USTILAGO AVENAE USTILAGO AVENAE USTILAGO TRITICI USTILAGO TRITICI GLYCERIN SODIUM BICARBONATE SODIUM CHLORIDE WATER Grain Smut Mixture Grain Smut Mixture USTILAGO NUDA HORDEI USTILAGO NUDA HORDEI USTILAGO MAYDIS USTILAGO MAYDIS USTILAGO AVENAE USTILAGO AVENAE USTILAGO TRITICI USTILAGO TRITICI GLYCERIN SODIUM BICARBONATE SODIUM CHLORIDE WATER Grass Smut Mixture Grass Smut Mixture USTILAGO CYNODONTIS USTILAGO CYNODONTIS SPORISORIUM CRUENTUM SPORISORIUM CRUENTUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Grass Smut Mixture Grass Smut Mixture USTILAGO CYNODONTIS USTILAGO CYNODONTIS SPORISORIUM CRUENTUM SPORISORIUM CRUENTUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER B Mold Mixture B Mold Mixture TRICHOTHECIUM ROSEUM TRICHOTHECIUM ROSEUM PASSALORA FULVA PASSALORA FULVA COCHLIOBOLUS SPICIFER COCHLIOBOLUS SPICIFER MYROTHECIUM VERRUCARIA MYROTHECIUM VERRUCARIA HYPOMYCES PERNICIOSUS HYPOMYCES PERNICIOSUS NEUROSPORA CRASSA NEUROSPORA CRASSA KHUSKIA ORYZAE KHUSKIA ORYZAE PAECILOMYCES VARIOTII PAECILOMYCES VARIOTII MICROASCUS BREVICAULIS MICROASCUS BREVICAULIS COLLETOTRICHUM COCCODES COLLETOTRICHUM COCCODES PLEOSPORA HERBARUM PLEOSPORA HERBARUM STREPTOMYCES GRISEUS STREPTOMYCES GRISEUS TRICHODERMA VIRIDE TRICHODERMA VIRIDE TRICHOPHYTON SCHOENLEINII TRICHOPHYTON SCHOENLEINII GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER B Mold Mixture B Mold Mixture TRICHOTHECIUM ROSEUM TRICHOTHECIUM ROSEUM PASSALORA FULVA PASSALORA FULVA COCHLIOBOLUS SPICIFER COCHLIOBOLUS SPICIFER MYROTHECIUM VERRUCARIA MYROTHECIUM VERRUCARIA HYPOMYCES PERNICIOSUS HYPOMYCES PERNICIOSUS NEUROSPORA CRASSA NEUROSPORA CRASSA KHUSKIA ORYZAE KHUSKIA ORYZAE PAECILOMYCES VARIOTII PAECILOMYCES VARIOTII MICROASCUS BREVICAULIS MICROASCUS BREVICAULIS COLLETOTRICHUM COCCODES COLLETOTRICHUM COCCODES PLEOSPORA HERBARUM PLEOSPORA HERBARUM STREPTOMYCES GRISEUS STREPTOMYCES GRISEUS TRICHODERMA VIRIDE TRICHODERMA VIRIDE TRICHOPHYTON SCHOENLEINII TRICHOPHYTON SCHOENLEINII GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER A Mold Mixture A Mold Mixture ASPERGILLUS FLAVUS ASPERGILLUS FLAVUS ASPERGILLUS FUMIGATUS ASPERGILLUS FUMIGATUS ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS REPENS ASPERGILLUS REPENS BOTRYTIS CINEREA BOTRYTIS CINEREA CHAETOMIUM GLOBOSUM CHAETOMIUM GLOBOSUM EPICOCCUM NIGRUM EPICOCCUM NIGRUM FUSARIUM OXYSPORUM FUSARIUM OXYSPORUM GEOTRICHUM CANDIDUM GEOTRICHUM CANDIDUM COCHLIOBOLUS SATIVUS COCHLIOBOLUS SATIVUS CANDIDA TROPICALIS CANDIDA TROPICALIS NEUROSPORA INTERMEDIA NEUROSPORA INTERMEDIA MUCOR PLUMBEUS MUCOR PLUMBEUS MUCOR RACEMOSUS MUCOR RACEMOSUS PENICILLIUM CAMEMBERTI PENICILLIUM CAMEMBERTI PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM EXPANSUM PENICILLIUM EXPANSUM PENICILLIUM ITALICUM PENICILLIUM ITALICUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM ROQUEFORTI PENICILLIUM ROQUEFORTI PHOMA DESTRUCTIVA PHOMA DESTRUCTIVA AUREOBASIDIUM PULLULANS VAR. PULLUTANS AUREOBASIDIUM PULLULANS VAR. PULLUTANS RHIZOPUS STOLONIFER RHIZOPUS STOLONIFER RHODOTORULA RUBRA RHODOTORULA RUBRA SACCHAROMYCES CEREVISIAE SACCHAROMYCES CEREVISIAE RHIZOPUS STOLONIFER RHIZOPUS STOLONIFER GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Penicillium notatum Penicillium notatum PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Mucor Mixture Mucor Mixture MUCOR PLUMBEUS MUCOR PLUMBEUS MUCOR RACEMOSUS MUCOR RACEMOSUS RHIZOPUS STOLONIFER RHIZOPUS STOLONIFER GLYCERIN SODIUM BICARBONATE WATER SODIUM CHLORIDE A Mold Mixture A Mold Mixture ASPERGILLUS FLAVUS ASPERGILLUS FLAVUS ASPERGILLUS FUMIGATUS ASPERGILLUS FUMIGATUS ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS REPENS ASPERGILLUS REPENS BOTRYTIS CINEREA BOTRYTIS CINEREA CHAETOMIUM GLOBOSUM CHAETOMIUM GLOBOSUM EPICOCCUM NIGRUM EPICOCCUM NIGRUM FUSARIUM OXYSPORUM FUSARIUM OXYSPORUM GEOTRICHUM CANDIDUM GEOTRICHUM CANDIDUM COCHLIOBOLUS SATIVUS COCHLIOBOLUS SATIVUS CANDIDA TROPICALIS CANDIDA TROPICALIS NEUROSPORA INTERMEDIA NEUROSPORA INTERMEDIA MUCOR PLUMBEUS MUCOR PLUMBEUS MUCOR RACEMOSUS MUCOR RACEMOSUS PENICILLIUM CAMEMBERTI PENICILLIUM CAMEMBERTI PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM EXPANSUM PENICILLIUM EXPANSUM PENICILLIUM ITALICUM PENICILLIUM ITALICUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM ROQUEFORTI PENICILLIUM ROQUEFORTI PHOMA DESTRUCTIVA PHOMA DESTRUCTIVA AUREOBASIDIUM PULLULANS VAR. PULLUTANS AUREOBASIDIUM PULLULANS VAR. PULLUTANS RHIZOPUS STOLONIFER RHIZOPUS STOLONIFER RHODOTORULA RUBRA RHODOTORULA RUBRA SACCHAROMYCES CEREVISIAE SACCHAROMYCES CEREVISIAE RHIZOPUS STOLONIFER RHIZOPUS STOLONIFER GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Trichophyton Mixture Trichophyton Mixture TRICHOPHYTON MENTAGROPHYTES TRICHOPHYTON MENTAGROPHYTES TRICHOPHYTON RUBRUM TRICHOPHYTON RUBRUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Penicillium Mixture Penicillium Mixture PENICILLIUM CAMEMBERTI PENICILLIUM CAMEMBERTI PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM EXPANSUM PENICILLIUM EXPANSUM PENICILLIUM ITALICUM PENICILLIUM ITALICUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM ROQUEFORTI PENICILLIUM ROQUEFORTI GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Number Ten Mold Mixture Number Ten Mold Mixture ALTERNARIA ALTERNATA ALTERNARIA ALTERNATA ASPERGILLUS FLAVUS ASPERGILLUS FLAVUS ASPERGILLUS FUMIGATUS ASPERGILLUS FUMIGATUS ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS REPENS ASPERGILLUS REPENS FUSARIUM OXYSPORUM FUSARIUM OXYSPORUM COCHLIOBOLUS SATIVUS COCHLIOBOLUS SATIVUS CLADOSPORIUM CLADOSPORIOIDES CLADOSPORIUM CLADOSPORIOIDES MUCOR RACEMOSUS MUCOR RACEMOSUS PENICILLIUM CAMEMBERTI PENICILLIUM CAMEMBERTI PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM EXPANSUM PENICILLIUM EXPANSUM PENICILLIUM ITALICUM PENICILLIUM ITALICUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM ROQUEFORTI PENICILLIUM ROQUEFORTI PHOMA DESTRUCTIVA PHOMA DESTRUCTIVA AUREOBASIDIUM PULLULANS VAR. PULLUTANS AUREOBASIDIUM PULLULANS VAR. PULLUTANS RHIZOPUS STOLONIFER RHIZOPUS STOLONIFER GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Trichophyton Mixture Trichophyton Mixture TRICHOPHYTON MENTAGROPHYTES TRICHOPHYTON MENTAGROPHYTES TRICHOPHYTON RUBRUM TRICHOPHYTON RUBRUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Phoma Phoma PHOMA DESTRUCTIVA PHOMA DESTRUCTIVA GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Nigrospora Nigrospora KHUSKIA ORYZAE KHUSKIA ORYZAE GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Pullularia Pullularia AUREOBASIDIUM PULLULANS VAR. PULLUTANS AUREOBASIDIUM PULLULANS VAR. PULLUTANS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Pullularia Pullularia AUREOBASIDIUM PULLULANS VAR. PULLUTANS AUREOBASIDIUM PULLULANS VAR. PULLUTANS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Candida albicans Candida albicans CANDIDA ALBICANS CANDIDA ALBICANS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Mycogone perniciosa Mycogone perniciosa HYPOMYCES PERNICIOSUS HYPOMYCES PERNICIOSUS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Mucor racemosus Mucor racemosus MUCOR RACEMOSUS MUCOR RACEMOSUS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Candida albicans Candida albicans CANDIDA ALBICANS CANDIDA ALBICANS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Trichoderma Trichoderma TRICHODERMA VIRIDE TRICHODERMA VIRIDE GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Stachybotrys Stachybotrys STACHYBOTRYS CHARTARUM STACHYBOTRYS CHARTARUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Aspergillus Mixture Aspergillus Mixture ASPERGILLUS FLAVUS ASPERGILLUS FLAVUS ASPERGILLUS FUMIGATUS ASPERGILLUS FUMIGATUS ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS REPENS ASPERGILLUS REPENS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Trichophyton rubrum Trichophyton rubrum TRICHOPHYTON RUBRUM TRICHOPHYTON RUBRUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Rhizopus Rhizopus RHIZOPUS STOLONIFER RHIZOPUS STOLONIFER GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Paecilomyces Paecilomyces PAECILOMYCES VARIOTII PAECILOMYCES VARIOTII GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Stemphylium Stemphylium PLEOSPORA HERBARUM PLEOSPORA HERBARUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Spondylocladium Spondylocladium COLLETOTRICHUM COCCODES COLLETOTRICHUM COCCODES GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Wheat Smut Wheat Smut USTILAGO TRITICI USTILAGO TRITICI GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Gliocladium Gliocladium MYROTHECIUM VERRUCARIA MYROTHECIUM VERRUCARIA GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Fusarium oxysporum Fusarium oxysporum FUSARIUM OXYSPORUM FUSARIUM OXYSPORUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Hormodendrum Hormodendrum CLADOSPORIUM CLADOSPORIOIDES CLADOSPORIUM CLADOSPORIOIDES GLYCERIN SODIUM BICARBONATE WATER SODIUM CHLORIDE Geotrichum candidum Geotrichum candidum GEOTRICHUM CANDIDUM GEOTRICHUM CANDIDUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Cladosporium herbarum Cladosporium herbarum CLADOSPORIUM HERBARUM CLADOSPORIUM HERBARUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Corn Smut Corn Smut USTILAGO MAYDIS USTILAGO MAYDIS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Epidermophyton Epidermophyton EPIDERMOPHYTON FLOCCOSUM EPIDERMOPHYTON FLOCCOSUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Epicoccum Epicoccum EPICOCCUM NIGRUM EPICOCCUM NIGRUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Candida albicans Candida albicans CANDIDA ALBICANS CANDIDA ALBICANS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Candida tropicalis Candida tropicalis CANDIDA TROPICALIS CANDIDA TROPICALIS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Mucor racemosus Mucor racemosus MUCOR RACEMOSUS MUCOR RACEMOSUS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Johnson Grass Smut Johnson Grass Smut SPORISORIUM CRUENTUM SPORISORIUM CRUENTUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Helminthosporium Helminthosporium COCHLIOBOLUS SATIVUS COCHLIOBOLUS SATIVUS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Microsporum audouinii Microsporum audouinii MICROSPORUM AUDOUINII MICROSPORUM AUDOUINII GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Mycogone perniciosa Mycogone perniciosa HYPOMYCES PERNICIOSUS HYPOMYCES PERNICIOSUS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Aspergillus fumigatus Aspergillus fumigatus ASPERGILLUS FUMIGATUS ASPERGILLUS FUMIGATUS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Aspergillus repens Aspergillus repens ASPERGILLUS REPENS ASPERGILLUS REPENS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Aspergillus niger Aspergillus niger ASPERGILLUS NIGER VAR. NIGER ASPERGILLUS NIGER VAR. NIGER GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Aspergillus flavus Aspergillus flavus ASPERGILLUS FLAVUS ASPERGILLUS FLAVUS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Trichophyton schoenleinii Trichophyton schoenleinii TRICHOPHYTON SCHOENLEINII TRICHOPHYTON SCHOENLEINII GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Alternaria alternata Alternaria alternata ALTERNARIA ALTERNATA ALTERNARIA ALTERNATA GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Acrothecium robustum Acrothecium robustum ACROTHECIUM ROBUSTUM ACROTHECIUM ROBUSTUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Absidia ramosa Absidia ramosa MYCOCLADUS CORYMBIFERUS MYCOCLADUS CORYMBIFERUS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Cephalothecium Cephalothecium TRICHOTHECIUM ROSEUM TRICHOTHECIUM ROSEUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Chaetomium Chaetomium CHAETOMIUM GLOBOSUM CHAETOMIUM GLOBOSUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Curvularia Curvularia COCHLIOBOLUS SPICIFER COCHLIOBOLUS SPICIFER GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Cladosporium fulvum Cladosporium fulvum PASSALORA FULVA PASSALORA FULVA GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Bermuda Grass Smut Bermuda Grass Smut USTILAGO CYNODONTIS USTILAGO CYNODONTIS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Botrytis Botrytis BOTRYTIS CINEREA BOTRYTIS CINEREA GLYCERIN SODIUM BICARBONATE WATER SODIUM CHLORIDE Cephalosporium Cephalosporium ACREMONIUM STRICTUM ACREMONIUM STRICTUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Barley Smut Barley Smut USTILAGO NUDA HORDEI USTILAGO NUDA HORDEI GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Spondylocladium Spondylocladium COLLETOTRICHUM COCCODES COLLETOTRICHUM COCCODES GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Scopulariopsis Scopulariopsis MICROASCUS BREVICAULIS MICROASCUS BREVICAULIS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Streptomyces Streptomyces STREPTOMYCES GRISEUS STREPTOMYCES GRISEUS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Stemphylium Stemphylium PLEOSPORA HERBARUM PLEOSPORA HERBARUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Rhizopus Rhizopus RHIZOPUS STOLONIFER RHIZOPUS STOLONIFER GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Penicillium italicum Penicillium italicum PENICILLIUM ITALICUM PENICILLIUM ITALICUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Saccharomyces Saccharomyces SACCHAROMYCES CEREVISIAE SACCHAROMYCES CEREVISIAE GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Rhodotorula Rhodotorula RHODOTORULA RUBRA RHODOTORULA RUBRA GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Trichophyton rubrum Trichophyton rubrum TRICHOPHYTON RUBRUM TRICHOPHYTON RUBRUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Tetracoccosporium paxianum Tetracoccosporium paxianum TETRACOCCOSPORIUM PAXIANUM TETRACOCCOSPORIUM PAXIANUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Verticillium Verticillium VERTICILLIUM ALBO-ATRUM VERTICILLIUM ALBO-ATRUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Trichophyton mentagrophytes Trichophyton mentagrophytes TRICHOPHYTON MENTAGROPHYTES TRICHOPHYTON MENTAGROPHYTES GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Stachybotrys Stachybotrys STACHYBOTRYS CHARTARUM STACHYBOTRYS CHARTARUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Sporotrichum Sporotrichum SPOROTRICHUM PRUINOSUM SPOROTRICHUM PRUINOSUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Trichoderma Trichoderma TRICHODERMA VIRIDE TRICHODERMA VIRIDE GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Syncephalastrum Syncephalastrum SYNCEPHALASTRUM RACEMOSUM SYNCEPHALASTRUM RACEMOSUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Oat Smut Oat Smut USTILAGO AVENAE USTILAGO AVENAE GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Nigrospora Nigrospora KHUSKIA ORYZAE KHUSKIA ORYZAE GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Pullularia Pullularia AUREOBASIDIUM PULLULANS VAR. PULLUTANS AUREOBASIDIUM PULLULANS VAR. PULLUTANS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Phoma Phoma PHOMA DESTRUCTIVA PHOMA DESTRUCTIVA GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Mucor mucedo Mucor mucedo RHIZOPUS STOLONIFER RHIZOPUS STOLONIFER GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Neurospora intermedia Neurospora intermedia NEUROSPORA INTERMEDIA NEUROSPORA INTERMEDIA GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Neurospora crassa Neurospora crassa NEUROSPORA CRASSA NEUROSPORA CRASSA GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Mucor plumbeus Mucor plumbeus MUCOR PLUMBEUS MUCOR PLUMBEUS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Penicillium camembertii Penicillium camembertii PENICILLIUM CAMEMBERTI PENICILLIUM CAMEMBERTI GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Penicillium roquefortii Penicillium roquefortii PENICILLIUM ROQUEFORTI PENICILLIUM ROQUEFORTI GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Penicillium expansum Penicillium expansum PENICILLIUM EXPANSUM PENICILLIUM EXPANSUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Penicillium chrysogenum Penicillium chrysogenum PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Papularia Papularia APIOSPORA MONTAGNEI APIOSPORA MONTAGNEI GLYCERIN SODIUM BICARBONATE WATER SODIUM CHLORIDE Paecilomyces Paecilomyces PAECILOMYCES VARIOTII PAECILOMYCES VARIOTII GLYCERIN SODIUM CHLORIDE WATER SODIUM BICARBONATE Penicillium notatum Penicillium notatum PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM PENICILLIUM CHRYSOGENUM VAR. CHRYSOGENUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Phycomyces Phycomyces PHYCOMYCES BLAKESLEEANUS PHYCOMYCES BLAKESLEEANUS GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER Humicola grisea Humicola grisea HUMICOLA GRISEA HUMICOLA GRISEA GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER C Mold Mixture C Mold Mixture MYCOCLADUS CORYMBIFERUS MYCOCLADUS CORYMBIFERUS ACROTHECIUM ROBUSTUM ACROTHECIUM ROBUSTUM HUMICOLA GRISEA HUMICOLA GRISEA MICROSPORUM AUDOUINII MICROSPORUM AUDOUINII MICROSPORUM CANIS MICROSPORUM CANIS APIOSPORA MONTAGNEI APIOSPORA MONTAGNEI PHYCOMYCES BLAKESLEEANUS PHYCOMYCES BLAKESLEEANUS SPOROTRICHUM PRUINOSUM SPOROTRICHUM PRUINOSUM STACHYBOTRYS CHARTARUM STACHYBOTRYS CHARTARUM SYNCEPHALASTRUM RACEMOSUM SYNCEPHALASTRUM RACEMOSUM TETRACOCCOSPORIUM PAXIANUM TETRACOCCOSPORIUM PAXIANUM VERTICILLIUM ALBO-ATRUM VERTICILLIUM ALBO-ATRUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER C Mold Mixture C Mold Mixture MYCOCLADUS CORYMBIFERUS MYCOCLADUS CORYMBIFERUS ACROTHECIUM ROBUSTUM ACROTHECIUM ROBUSTUM HUMICOLA GRISEA HUMICOLA GRISEA MICROSPORUM AUDOUINII MICROSPORUM AUDOUINII MICROSPORUM CANIS MICROSPORUM CANIS APIOSPORA MONTAGNEI APIOSPORA MONTAGNEI PHYCOMYCES BLAKESLEEANUS PHYCOMYCES BLAKESLEEANUS SPOROTRICHUM PRUINOSUM SPOROTRICHUM PRUINOSUM STACHYBOTRYS CHARTARUM STACHYBOTRYS CHARTARUM SYNCEPHALASTRUM RACEMOSUM SYNCEPHALASTRUM RACEMOSUM TETRACOCCOSPORIUM PAXIANUM TETRACOCCOSPORIUM PAXIANUM VERTICILLIUM ALBO-ATRUM VERTICILLIUM ALBO-ATRUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER C Mold Mixture C Mold Mixture MYCOCLADUS CORYMBIFERUS MYCOCLADUS CORYMBIFERUS ACROTHECIUM ROBUSTUM ACROTHECIUM ROBUSTUM HUMICOLA GRISEA HUMICOLA GRISEA MICROSPORUM AUDOUINII MICROSPORUM AUDOUINII MICROSPORUM CANIS MICROSPORUM CANIS APIOSPORA MONTAGNEI APIOSPORA MONTAGNEI PHYCOMYCES BLAKESLEEANUS PHYCOMYCES BLAKESLEEANUS SPOROTRICHUM PRUINOSUM SPOROTRICHUM PRUINOSUM STACHYBOTRYS CHARTARUM STACHYBOTRYS CHARTARUM SYNCEPHALASTRUM RACEMOSUM SYNCEPHALASTRUM RACEMOSUM TETRACOCCOSPORIUM PAXIANUM TETRACOCCOSPORIUM PAXIANUM VERTICILLIUM ALBO-ATRUM VERTICILLIUM ALBO-ATRUM GLYCERIN SODIUM CHLORIDE SODIUM BICARBONATE WATER"],"storage_and_handling":["STORAGE Store all stock concentrates and dilutions at 2-8° C. Keep at this temperature during office use. The expiration date of the allergenic extracts is listed on the container label. Dilutions of the allergenic extracts containing less than 50% glycerine are less stable. If loss of potency is suspected, potency can be checked using side by side skin testing with freshly prepared dilutions of equal concentration on individuals with known sensitivity to the allergen."],"version":"1","warnings":["WARNINGS Refer to boxed “WARNINGS”, “PRECAUTIONS”, “ADVERSE REACTIONS” and “OVERDOSAGE” sections for additional information on serious adverse reactions and steps to be taken, if any occur. Extreme caution is necessary when using diagnostic skin tests or injection treatment in highly sensitive patients who have experienced severe symptoms or anaphylaxis by natural exposure, or during previous skin testing or treatment. IN THESE CASES THE POTENCY FOR SKIN TESTS AND THE ESCALATION OF THE TREATMENT DOSE MUST BE ADJUSTED TO THE PATIENT’S SENSITIVITY AND TOLERANCE. Benefit versus risk needs to be evaluated in steroid dependent asthmatics, patients with unstable asthma or patients with underlying cardiovascular disease. Injections should never be given intravenously. A 5/8 inch, 25 gauge needle on a sterile syringe allows deep subcutaneous injection. Withdraw plunger slightly after inserting needle to determine if a blood vessel has been entered. Proper measurement of dose and caution in making injection will minimize reactions. Adverse reactions to allergenic extracts are usually apparent within 20-30 minutes following injection of immunotherapy. Extract should be temporarily withheld or dosage reduced in case of any of the following conditions: 1) flu or other infection with fever; 2) exposure to excessive amounts of allergen prior to injection; 3) rhinitis and/or asthma exhibiting severe symptoms; 4) adverse reaction to previous injection until cause of reaction has been evaluated by physician supervising patient’s immunotherapy program."]}