{"dosage_and_administration":["DOSAGE AND ADMINISTRATION Apply 2 pumps (1g) to affected areas twice a day or as directed by a physician. Always use sunscreen protection. (See enclosed package insert for full prescribing information.)"],"effective_time":"20250203","id":"2d4578ad-1742-6f8f-e063-6294a90a3d1c","openfda":{"brand_name":["ZO Skin Health Pigment Control Creme Hydroquinone"],"generic_name":["HYDROQUINONE"],"is_original_packager":[true],"manufacturer_name":["ZO Skin Health, Inc."],"nui":["N0000175851","N0000175854","N0000175850"],"package_ndc":["42851-037-80","42851-037-30"],"pharm_class_epc":["Melanin Synthesis Inhibitor [EPC]"],"pharm_class_moa":["Melanin Synthesis Inhibitors [MoA]"],"pharm_class_pe":["Depigmenting Activity [PE]"],"product_ndc":["42851-037"],"product_type":["HUMAN PRESCRIPTION DRUG"],"route":["TOPICAL"],"rxcui":["1235391"],"spl_id":["2d4578ad-1742-6f8f-e063-6294a90a3d1c"],"spl_set_id":["83e34a75-d20c-43ab-be31-f8fcafec46d0"],"substance_name":["HYDROQUINONE"],"unii":["XV74C1N1AE"]},"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL - 80 mL Bottle Carton ZO ® SKIN HEALTH BY ZEIN OBAGI MD PIGMENT CONTROL CRÈME 4% Hydroquinone RX ONLY NDC 42851-037-80 80 mL / 2.7 Fl. Oz. PDP"],"set_id":"83e34a75-d20c-43ab-be31-f8fcafec46d0","spl_product_data_elements":["ZO Skin Health Pigment Control Creme Hydroquinone Hydroquinone HYDROQUINONE HYDROQUINONE WATER ASCORBIC ACID ASCORBYL PALMITATE CAPRYLYL GLYCOL CETYL ALCOHOL CHLORPHENESIN DIOSCOREA VILLOSA TUBER EDETATE DISODIUM ANHYDROUS GLYCERIN GLYCOLIC ACID PHENOXYETHANOL QUILLAJA SAPONARIA BARK SMILAX ARISTOLOCHIIFOLIA ROOT SODIUM HYDROXIDE SODIUM LAURYL SULFATE SODIUM METABISULFITE SODIUM SULFITE STEARYL ALCOHOL .ALPHA.-TOCOPHEROL ACETATE YUCCA SCHIDIGERA ROOT"],"spl_unclassified_section":["SUNBURN ALERT This product contains an alpha hydroxy acid (AHA) that may increase your skin's sensitivity to the sun and particularly the possibility of sunburn. Use a sunscreen, wear protective clothing, and limit sun exposure while using this product and for a week afterward.","ACTIVE INGREDIENT Hydroquinone 4%","INACTIVE INGREDIENTS Aqua/Water/Eau, Ascorbic Acid, Ascorbyl Palmitate, Beta-Glucan, Caprylyl Glycol, Cetyl Alcohol, Chlorphenesin, Dioscorea Villosa (Wild Yam) Root Extract, Disodium EDTA, Glycerin, Glycolic Acid, Phenoxyethanol, Quillaja Saponaria Bark Extract, Smilax Aristolochiifolia Root Extract, Sodium Hydroxide, Sodium Lauryl Sulfate, Sodium Metabisulfite, Sodium Sulfite, Stearyl Alcohol, Tocopheryl Acetate, Yucca Schidigera Root Extract.","Dist. by ZO Skin Health, Inc. Irvine, CA 92618"],"storage_and_handling":["STORAGE Store at controlled room temperature: 15°-30°C (59°-86°F), away from direct sunlight."],"version":"5","warnings":["WARNINGS Keep out of reach of children. Contains Sodium Metabisulfite, a sulfite that may cause serious allergic-type reactions, including anaphylactic symptoms (e.g., hives, itching) and life-threatening or less-severe asthmatic episodes in certain susceptible persons. For external use only. Avoid contact with the eyes. Some users may experience a mild skin irritation. If skin irritation becomes severe, stop use and consult a physician. Do not use on children under 12 years of age unless directed by a physician. If swallowed, get medical help or contact a poison control center right away."]}