{"active_ingredient":["DRUG FACTS Active Ingredients Micronizrd Estriol USP (Wild Yam) .4% Micronizrd Estradiol USP (Wild Yam) .1%"],"dosage_and_administration":["Apply once or twice a day. Massage into inner arms, thighs, chest or apply to inner forearm and rub arms together or use as directed by you physician."],"effective_time":"20250601","id":"37ca001c-de9a-f819-e063-6294a90a4c08","inactive_ingredient":["Purified Water, Vegetable Glycerin, Aloe Vera Gel, Caprylic/Capric Triglyceride,Stearic Acid,Olive Oil, Coconut Oil, Shea Butter, Sunflower Lecithin, Methylsulfonylmethane (MSM), Stearyl Alcohol, Isopropyl Palmitate,Allantoin,Carbomer, Sodium Bicarbonate, Herbal-Active (Natural Preservstive)"],"indications_and_usage":["USES: This is a topical cream that contains bio-identical estriol and estradiol derived from wild yam and formulated in an 80:20 ratio. When applied to the skin it can help balance your hormones and provide temporary relief from menopausal symptoms such as hot flashes. DIRECTIONS: Apply once or twice a day. Massage into inner arms, thighs, chest or apply to inner forearm and rub arms together or use as directed by your Physician."],"keep_out_of_reach_of_children":["Keep Out of Reach of Children."],"openfda":{"brand_name":["BiEST 5.0 Estrogen Cream"],"generic_name":["ESTRIOL,ESTRADIOL"],"is_original_packager":[true],"manufacturer_name":["SHYNE BRANDS"],"nui":["M0447348","N0000175825","N0000000100"],"package_ndc":["82018-0009-3"],"pharm_class_cs":["Estradiol Congeners [CS]"],"pharm_class_epc":["Estrogen [EPC]"],"pharm_class_moa":["Estrogen Receptor Agonists [MoA]"],"product_ndc":["82018-0009"],"product_type":["HUMAN OTC DRUG"],"route":["TRANSDERMAL"],"spl_id":["37ca001c-de9a-f819-e063-6294a90a4c08"],"spl_set_id":["c4d3860f-c211-b18c-e053-2a95a90a4474"],"substance_name":["ESTRIOL","ESTRADIOL"],"unii":["FB33469R8E","4TI98Z838E"],"upc":["0852178008346"]},"package_label_principal_display_panel":["BiEST 5.0 Label"],"pregnancy_or_breast_feeding":["If pregnant or nursing or if you have a serious medical condition consult a healthcare professional before using this product."],"purpose":["This is a topical cream that contains bio-identical estriol and estradiol derived from wild yam and formulated in an 80:20 ratio. When applied to the skin it can help balance your hormones and provide temporary relief from menopausal symptoms such as hot flashes."],"questions":["Questions? care@biolabspro.com www.biolabspro.com"],"set_id":"c4d3860f-c211-b18c-e053-2a95a90a4474","spl_product_data_elements":["BiEST 5.0 Estrogen Cream estriol,estradiol GLYCERIN ALLANTOIN LECITHIN, SUNFLOWER ESTRIOL ESTRIOL ESTRADIOL ESTRADIOL ISOPROPYL PALMITATE STEARIC ACID SHEA BUTTER ALOE VERA LEAF COCONUT OIL SODIUM BICARBONATE OLIVE OIL"],"version":"4","warnings":["For external cosmetic use only. If pregnant or nursing, consult a healthcare professional before using this product. Cease using this product and seek medical attention if skin irritation or other negative reactions occur. Do not use if tamper-evident seal is broken or missing. California Prop 65 Law requires this statement: This product contains estrogen, a chemical known only to the state of California to cause cancer. KEEP OUT OF REACH OF CHILDREN."]}