{"active_ingredient":["Active ingredient (in each caplet) Acetaminophen 250 mg Aspirin 250 mg (NSAID)* Caffeine 65 mg *nonsteroidal anti-inflammatory drug"],"ask_doctor":["Ask a doctor before use if •stomach bleeding warning applies to you •you have a history of stomach problems, such as heartburn •you have high blood pressure, heart disease, liver cirrhosis or kidney disease •you are taking a diuretic"],"ask_doctor_or_pharmacist":["Ask a doctor or pharmacist before use if you are •taking a prescription drug for diabetes, gout, or arthritis •taking any other drug or are under a doctor’s care for any serious condition"],"do_not_use":["Do not use •with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. •for more than 10 days for pain unless directed by a doctor •for more than 3 days for fever unless directed by a doctor"],"dosage_and_administration":["Directions: •do not use more than directed •drink a full glass of water with each dose •adults and children 12 years and over: take 2 caplets every 6 hours; not more than 8 caplets in 24 hours •children under 12 years: ask a doctor"],"effective_time":"20250710","id":"3992e879-0f22-1e3f-e063-6294a90a67f8","inactive_ingredient":["Inactive ingredients carnauba wax, colloidal silicon dioxide, hypromellose, microcrystalline cellulose, mineral oil, pregelatinized starch, povidone, sodium starch glycolate, stearic acid, titanium dioxide"],"indications_and_usage":["Uses temporarily relieves minor aches and pains due to: •headache •a cold •arthritis •muscular aches •toothache •premenstrual and menstrual cramps"],"keep_out_of_reach_of_children":["Keep out of reach of children. In case of accidental overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away. Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms."],"openfda":{"application_number":["M012"],"brand_name":["HEADACHE RELIEF"],"generic_name":["ACETAMINOPHEN, ASPIRIN AND CAFFEINE"],"is_original_packager":[true],"manufacturer_name":["Kroger Company"],"nui":["N0000175739","N0000175729","N0000175790","M0023046","N0000000160","N0000008836","M0001335","N0000175722","N0000175578","N0000008832"],"package_ndc":["41226-370-42","41226-370-01"],"pharm_class_cs":["Xanthines [CS]","Anti-Inflammatory Agents, Non-Steroidal [CS]"],"pharm_class_epc":["Central Nervous System Stimulant [EPC]","Methylxanthine [EPC]","Nonsteroidal Anti-inflammatory Drug [EPC]","Platelet Aggregation Inhibitor [EPC]"],"pharm_class_moa":["Cyclooxygenase Inhibitors [MoA]"],"pharm_class_pe":["Central Nervous System Stimulation [PE]","Decreased Prostaglandin Production [PE]","Decreased Platelet Aggregation [PE]"],"product_ndc":["41226-370"],"product_type":["HUMAN OTC DRUG"],"route":["ORAL"],"rxcui":["308297"],"spl_id":["3992e879-0f22-1e3f-e063-6294a90a67f8"],"spl_set_id":["bbed29a1-3c52-3531-e053-2995a90a686c"],"substance_name":["CAFFEINE","ASPIRIN","ACETAMINOPHEN"],"unii":["3G6A5W338E","R16CO5Y76E","362O9ITL9D"]},"package_label_principal_display_panel":["headache-100ct-carton headache-100ct-carton"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery."],"purpose":["Pain reliever/Pain reliever aid"],"questions":["Questions or comments? call 1-800-632-6900"],"set_id":"bbed29a1-3c52-3531-e053-2995a90a686c","spl_product_data_elements":["HEADACHE RELIEF ACETAMINOPHEN, ASPIRIN AND CAFFEINE TITANIUM DIOXIDE CELLULOSE, MICROCRYSTALLINE SILICON DIOXIDE HYPROMELLOSES STEARIC ACID STARCH, CORN POVIDONE MINERAL OIL CAFFEINE CAFFEINE ASPIRIN ASPIRIN SODIUM STARCH GLYCOLATE TYPE A CORN CARNAUBA WAX ACETAMINOPHEN ACETAMINOPHEN TCL;370 (Capsule Shaped Tablet)"],"spl_unclassified_section":["DRUG FACTS ACETAMINOPHEN/ ASPIRIN (NSAID)/ CAFFEINE","OTHER INFORMATION Other information store at 25°C (77°F); excursions permitted between 15°-30°C (59°-86°F) use by expiration date on package"],"stop_use":["Stop using and ask a doctor if •symptoms do not improve •new symptoms occur •pain or fever persists or gets worse •you experience any of the following signs of stomach bleeding: feel faint have bloody or black stools vomit blood have stomach pain that does not get better •ringing in the ears or loss of hearing occurs, consult a doctor before taking any more of this product."],"version":"4","warnings":["Warnings Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye's syndrome, a rare but serious illness. Allergy alert: Aspirin may cause a severe allergic reaction, which may include: •hives •facial swelling •shock •asthma (wheezing) Allergy alert : Acetaminophen may cause severe skin reactions. Symptoms may include: •skin reddening •blisters •rash If a skin reaction occurs, stop use and seek medical help right away. Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take: •more than 8 caplets in 24 hours, which is the maximum daily amount •with other drugs containing acetaminophen •3 or more alcoholic drinks every day while using this product Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you: •are age 60 or older •have had stomach ulcers or bleeding problems •take a blood thinning (anticoagulant) or steroid drug •take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) •have 3 or more alcoholic drinks every day while using this product •take more or for a longer time than directed Caffeine warning: The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability,sleeplessness, and occasionally, rapid heartbeat."]}