{"dosage_and_administration":["Directions Adults: •When practical, cleanse the affected area with mild soap and warm water, and rinse thoroughly. •Gently pat dry before use. •Hold the can upside-down and point spray nozzle 6 to 12 inches from affected area. •Apply externally up to 6 times daily or after each bowel movement. Children under 12 years of age: consult a doctor."],"effective_time":"20250815","id":"3c68d62a-134e-7268-e063-6394a90adba9","inactive_ingredient":["Inactive Ingredients aloe barbadensis leaf juice, citric acid, dimethyl ether, dipropylene glycol, ethanol, polyethylene glycol, potassium sorbate, PPG-3 methyl ether, sodium benzoate, witch hazel extract"],"indications_and_usage":["Uses ■ Helps relieve discomfort in the perianal area. ■ Temporarily protects inflamed perianal skin."],"keep_out_of_reach_of_children":["Keep out of reach of children. •If swallowed, get medical help or contact a Poison Control Center right away."],"openfda":{"application_number":["M015"],"brand_name":["Upside Down Pain Relief"],"generic_name":["BENZOCAINE, GLYCERIN"],"is_original_packager":[true],"manufacturer_name":["Fridababy, LLC"],"nui":["N0000185370","N0000175629","N0000184306","N0000185001","M0000728","M0009417","N0000185508"],"package_ndc":["72705-300-01"],"pharm_class_cs":["Allergens [CS]","Glycerol [CS]"],"pharm_class_epc":["Non-Standardized Chemical Allergen [EPC]","Standardized Chemical Allergen [EPC]"],"pharm_class_pe":["Increased Histamine Release [PE]","Cell-mediated Immunity [PE]","Increased IgG Production [PE]"],"product_ndc":["72705-300"],"product_type":["HUMAN OTC DRUG"],"route":["TOPICAL"],"spl_id":["3c68d62a-134e-7268-e063-6394a90adba9"],"spl_set_id":["31c2cd25-1fec-5ec5-e063-6394a90a24b4"],"substance_name":["GLYCERIN","BENZOCAINE"],"unii":["PDC6A3C0OX","U3RSY48JW5"]},"package_label_principal_display_panel":["Upside Sown Pain Relief Spray 3.5 oz Upside Down Pain Relief Spray 3.5 oz"],"purpose":["Purpose Local anesthetic Protectant"],"set_id":"31c2cd25-1fec-5ec5-e063-6394a90a24b4","spl_product_data_elements":["Upside Down Pain Relief Benzocaine, Glycerin GLYCERIN GLYCERIN BENZOCAINE BENZOCAINE HAMAMELIS VIRGINIANA ROOT BARK/STEM BARK POTASSIUM SORBATE ALOE BARBADENSIS LEAF JUICE CITRIC ACID SODIUM BENZOATE ALCOHOL 95% DIMETHYL ETHER POLYETHYLENE GLYCOL 300 PPG-3 METHYL ETHER"],"version":"2","warnings":["Warnings For extemal use only FLAMMABLE. Do not use near heat, flame, or fire or wlile smoking. When using this product ■ Use only as directed. ■ Do not exceed recommended daily dosage unless directed by a doctor. ■ Intentional misuse by deliberately concentrating or inhaling the contents can be hmmful or fatal. ■ Do not put this product into the rectum by using fingers or any mechanical device or applicator. Stop use and ask a doctor if ■ Condition worsens or does not improve within 7 days. ■ Bleeding occurs ■ Certain persons can develop allergic reactions to ingredients in this product. If the symptoms being treated does not subside or if redness, irritation, swelling, pain, or other syptoms develop or increase, discontinue use and consult a doctor. ■ Avoid spaying in eyes. ■ Contents under pressure. Do not puncture or incinerate. ■ Do not store at temperature above 120ºF. Keep out of reach of children. ■ If swallowed, get medical help or contact a Poison Control Cerier right away. Keep out of reach of children. •If swallowed, get medical help or contact a Poison Control Center right away."]}