{"active_ingredient":["Active ingredients (in each caplet) ​Aspirin (NSAID)* 500 mg Caffeine 32.5 mg *nonsteroidal anti-inflammatory drug"],"ask_doctor":["Ask a doctor before use if ■ stomach bleeding warning applies to you ■ you have a history of stomach problems, such as heartburn ■ you have asthma ■ you have high blood pressure, heart disease, liver cirrhosis, or kidney disease ■ you are taking a diuretic"],"ask_doctor_or_pharmacist":["Ask a doctor or pharmacist before use if you are taking a prescription drug for ■ gout ■ diabetes ■ arthritis"],"do_not_use":["Do not use ■ if you are allergic to aspirin or any other pain reliever/fever reducer. ■ if you have ever had an allergic reaction to this product or any of its ingredients"],"dosage_and_administration":["Directions ■ drink a full glass of water with each dose Adults and children (12 years and over): take 2 caplets every 6 hours, not to exceed 8 caplets in 24 hours Children under 12 years: do not use unless directed by a doctor"],"effective_time":"20250909","id":"3e5d5a8f-2740-dd38-e063-6394a90ab6af","inactive_ingredient":["Inactive ingredients corn starch, hypromellose, maltodextrin, microcrystalline cellulose, polyethylene glycol, sodium lauryl sulfate"],"indications_and_usage":["Uses for the temporary relief of ■ backache pain ■ muscle aches and pains ■ minor aches and pains of arthritis"],"keep_out_of_reach_of_children":["Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away."],"openfda":{"application_number":["M013"],"brand_name":["Medi First Pain Ache","Medi First Plus Pain Ache"],"generic_name":["ASPIRIN,CAFFEINE"],"is_original_packager":[true],"manufacturer_name":["Unifirst First Aid Corporation"],"nui":["N0000000160","N0000008836","M0001335","N0000175722","N0000175578","N0000008832","N0000175739","N0000175729","N0000175790","M0023046"],"package_ndc":["47682-921-80","47682-921-36","47682-821-99","47682-821-80","47682-821-36"],"pharm_class_cs":["Anti-Inflammatory Agents, Non-Steroidal [CS]","Xanthines [CS]"],"pharm_class_epc":["Nonsteroidal Anti-inflammatory Drug [EPC]","Platelet Aggregation Inhibitor [EPC]","Central Nervous System Stimulant [EPC]","Methylxanthine [EPC]"],"pharm_class_moa":["Cyclooxygenase Inhibitors [MoA]"],"pharm_class_pe":["Decreased Prostaglandin Production [PE]","Decreased Platelet Aggregation [PE]","Central Nervous System Stimulation [PE]"],"product_ndc":["47682-821","47682-921"],"product_type":["HUMAN OTC DRUG"],"route":["ORAL"],"rxcui":["702316"],"spl_id":["3e5d5a8f-2740-dd38-e063-6394a90ab6af"],"spl_set_id":["e82d02d5-3e44-a8f8-e053-2a95a90a2688"],"substance_name":["ASPIRIN","CAFFEINE"],"unii":["R16CO5Y76E","3G6A5W338E"],"upc":["0347682921804","0347682821807"]},"other_safety_information":["Other information ■ store at 25°C (77°F); excursions permitted between 15°-30°C (59°-86°F) ■ tamper evident sealed packets ■ do not use any opened or torn packets"],"package_label_principal_display_panel":["Medi-First® Pain & Ache Pain Reliever • Aspirin (NSAID) 500 mg Pain Reliever Aid • Caffeine 32.5 mg Fast Acting Advanced Formula Pull to Open This Package is for Households Without Young Children. Tamper Evident Unit Dose Packets 80 Caplets (40 x 2) Medi-First","Medi-First® Plus Pain & Ache Pain Reliever • Aspirin (NSAID) 500 mg Pain Reliever Aid • Caffeine 32.5 mg Extra Strength Pain Relief Fast Acting Advanced Formula Pull to Open This Package is for Households Without Young Children. Tamper Evident Unit Dose Packets 80 Caplets (40 x 2's) Medi-Hirst Plus"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless specifically directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery."],"purpose":["Purpose Pain reliever Pain reliever aid"],"questions":["Questions or comments? 1-800-634-7680"],"set_id":"e82d02d5-3e44-a8f8-e053-2a95a90a2688","spl_product_data_elements":["Medi First Plus Pain Ache Aspirin,Caffeine ASPIRIN ASPIRIN STARCH, CORN HYPROMELLOSE, UNSPECIFIED MALTODEXTRIN POLYETHYLENE GLYCOL, UNSPECIFIED CAFFEINE CAFFEINE MICROCRYSTALLINE CELLULOSE SODIUM LAURYL SULFATE Caplet 44;413 Medi First Pain Ache Aspirin,Caffeine ASPIRIN ASPIRIN STARCH, CORN HYPROMELLOSE, UNSPECIFIED MALTODEXTRIN POLYETHYLENE GLYCOL, UNSPECIFIED CAFFEINE CAFFEINE MICROCRYSTALLINE CELLULOSE SODIUM LAURYL SULFATE Caplet 44;413"],"spl_unclassified_section":["Drug Facts"],"stop_use":["Stop use and ask a doctor if ■ an allergic reaction occurs. Seek medical help right away. ■ you experience any of the following signs of stomach bleeding: ■ vomit blood ■ have bloody or black stools ■ feel faint ■ have stomach pain that does not get better ■ ringing in the ears or a loss of hearing occurs ■ pain gets worse or lasts more than 10 days ■ fever gets worse or lasts more than 3 days ■ redness or swelling is present ■ new symptoms occur These could be signs of a serious condition."],"version":"5","warnings":["Warnings Reye's syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye's syndrome, a rare but serious illness. Allergy alert: Aspirin may cause a severe allergic reaction which may include: ■ hives ■ shock ■ facial swelling ■ asthma (wheezing) Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you ■ take more or for a longer time than directed ■ take a blood thinning (anticoagulant) or steroid drug ■ are age 60 or older ■ have 3 or more alcohol drinks every day while using this product ■ have had stomach ulcers or bleeding problems ■ take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)"]}