{"active_ingredient":["Active ingredients Purpose Glycerin 14.4%............................................................Skin protectant Phenylephrine HCl 0.25%...........................................Vasconstrictor Pramoxine HCl 1%......................................................Local anesthetic White petrolatum 15%.................................................Skin protectant"],"ask_doctor":["Ask a doctor before use if you have heart disease high blood pressure thyroid disease difficult in urination due to enlargement of the prostate gland diabetes"],"dosage_and_administration":["Distributed by: Better Living Brands LLC Made in China"],"effective_time":"20251024","id":"41ecac83-195d-7b49-e063-6394a90a1b27","inactive_ingredient":["Inactive ingredients .alpha.-tocopherol acetate, aloe vera leaf, anhydrous lanolin, butylated hydroxytoluene, cetostearyl alcohol, cetyl esters wax, cetyl palmitate, glycryl monostearate, isopropyl myristate, light mineral oil, methylparaben, propylene glycol, propylparaben, purified water, steareth-20, stearic acid, trisodium citrate dihydrate"],"indications_and_usage":["Directions adults: when practical, cleanse the affected area by patting or blotting with an appropriate cleansing wipe. Gently dry by patting or blotting with a tissue or a soft cloth before applying cream. when first opening the tube, peel back foil seal apply externally or in the lower portion of the anal canal only apply externally to the affected area up to 4 times daily, especially at night, in the morning or after each bowel movement for application in the lower anal canal: remove cover from dispensing cap. Attach dispensing cap to tube. Lubricate dispensing cap well, then gently insert dispensing cap partway into the anus thoroughly cleanse dispensing cap after each use and replace cover children under 12 years of age: ask a doctor"],"keep_out_of_reach_of_children":["Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center (1-800-222-1222) right away."],"openfda":{"application_number":["M015"],"brand_name":["Signature Care Hemorrhoidal Cream (with applicator)"],"generic_name":["PHENYLEPHRINE HYDROCHLORIDE, PRAMOXINE HYDROCHLORIDE, GLYCERIN, PETROLATUM"],"is_original_packager":[true],"manufacturer_name":["BETTER LIVING BRANDS, LLC"],"nui":["N0000185370","N0000175629","N0000184306","N0000185001","M0000728","M0009417"],"package_ndc":["21130-981-02"],"pharm_class_cs":["Allergens [CS]","Glycerol [CS]"],"pharm_class_epc":["Non-Standardized Chemical Allergen [EPC]"],"pharm_class_pe":["Increased Histamine Release [PE]","Cell-mediated Immunity [PE]","Increased IgG Production [PE]"],"product_ndc":["21130-981"],"product_type":["HUMAN OTC DRUG"],"route":["TOPICAL"],"rxcui":["1293649"],"spl_id":["41ecac83-195d-7b49-e063-6394a90a1b27"],"spl_set_id":["b026a386-5e38-52ed-e053-2a95a90a6b0e"],"substance_name":["PHENYLEPHRINE HYDROCHLORIDE","PRAMOXINE HYDROCHLORIDE","GLYCERIN","PETROLATUM"],"unii":["04JA59TNSJ","88AYB867L5","PDC6A3C0OX","4T6H12BN9U"],"upc":["0321130789819"]},"package_label_principal_display_panel":["78981.1"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding, ask a health professional before use."],"purpose":["Uses for temporary relief of pain, soreness and burning helps relieve the local itching and discomfort associated with hemorrhoids temporarily shrinks hemorrhoidal tissue temporarily provides a coating for relief of anorectal discomforts temporarily protects the inflamed, irritated anorectal surface to make bowel movements less painful"],"set_id":"b026a386-5e38-52ed-e053-2a95a90a6b0e","spl_product_data_elements":["Signature Care Hemorrhoidal Cream (with applicator) Phenylephrine Hydrochloride, Pramoxine Hydrochloride, Glycerin, Petrolatum PHENYLEPHRINE HYDROCHLORIDE PHENYLEPHRINE STEARETH-20 PRAMOXINE HYDROCHLORIDE PRAMOXINE PROPYLENE GLYCOL METHYLPARABEN PROPYLPARABEN BUTYLATED HYDROXYTOLUENE WATER GLYCERIN GLYCERIN CETYL PALMITATE CETYL ESTERS WAX STEARIC ACID .ALPHA.-TOCOPHEROL ACETATE ALOE VERA LEAF LANOLIN GLYCERYL MONOSTEARATE PETROLATUM PETROLATUM TRISODIUM CITRATE DIHYDRATE ISOPROPYL MYRISTATE CETOSTEARYL ALCOHOL LIGHT MINERAL OIL"],"stop_use":["Stop use and ask a doctor if condition worsens or does not improve within 7 days bleeding occurs an allergic reaction develops the symptom being treated does not subside or if redness, irritation, swelling, pain or other symptoms develop or increase"],"storage_and_handling":["Other information store at room temperature 20-25°C (68-77°F)"],"version":"4","warnings":["Warnings For external and/or intrarectal use only"],"when_using":["When using this product do not exceed the recommended daily dosage unless directed by a doctor do not put into the rectum by using fingers or any mechanical device or applicator"]}