{"active_ingredient":["Active ingredients (in each caplet) Purpose Aspirin 500 mg (NSAID)*………………………...................Pain reliever/fever reducer Caffeine 32.5 mg……………………………….....................Pain reliever aid *nonsteroidal anti-inflammatory drug"],"ask_doctor":["Ask a doctor before use if ● stomach bleeding warning applies to you ● you have a history of stomach problems, such as heartburn ● you have high blood pressure, heart disease, liver cirrhosis, or kidney disease ● you are taking a diuretic ● you have asthma","Stop use and ask a doctor if an allergic reaction occurs. Seek medical help right away. you experience any of the following signs of stomach bleeding: feel faint vomit blood have bloody or black stools have stomach pain that does not get better pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur ringing in the ears or a loss of hearing occurs"],"ask_doctor_or_pharmacist":["Ask a doctor or pharmacist before use if you are taking a prescription drug for ● gout ● diabetes ● arthritis"],"do_not_use":["Do not use ● if you are allergic to aspirin or any other pain reliever/fever reducer ● if you have ever had an allergic reaction to this product or any of its Ingredients"],"dosage_and_administration":["Directions ● drink a full glass of water with each dose ● adults and children 12 years and over: take 2 caplets every 6 hours not to exceed 8 caplets in 24 hours ● children under 12 years: consult a doctor"],"effective_time":"20251204","id":"45263661-3ac2-6283-e063-6394a90ac1ec","inactive_ingredient":["Inactive ingredients carnauba wax, corn starch, D&C red #30 aluminum lake, D&C yellow #10 aluminum lake, hypromellose, powdered cellulose, propylene glycol, shellac, titanium dioxide, triacetin"],"indications_and_usage":["Uses Uses temporarily relieves minor aches and pains due to: headache toothache colds muscle pain minor pain of arthritis temporarily reduces fever"],"keep_out_of_reach_of_children":["Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away."],"openfda":{"application_number":["M013"],"brand_name":["Bayer Headache"],"generic_name":["ASPIRIN AND CAFFEINE"],"is_original_packager":[true],"manufacturer_name":["Bayer HealthCare LLC."],"nui":["N0000000160","N0000008836","M0001335","N0000175722","N0000175578","N0000008832","N0000175739","N0000175729","N0000175790","M0023046"],"package_ndc":["0280-0064-01","0280-0064-02"],"pharm_class_cs":["Anti-Inflammatory Agents, Non-Steroidal [CS]","Xanthines [CS]"],"pharm_class_epc":["Nonsteroidal Anti-inflammatory Drug [EPC]","Platelet Aggregation Inhibitor [EPC]","Central Nervous System Stimulant [EPC]","Methylxanthine [EPC]"],"pharm_class_moa":["Cyclooxygenase Inhibitors [MoA]"],"pharm_class_pe":["Decreased Prostaglandin Production [PE]","Decreased Platelet Aggregation [PE]","Central Nervous System Stimulation [PE]"],"product_ndc":["0280-0064"],"product_type":["HUMAN OTC DRUG"],"route":["ORAL"],"rxcui":["702316"],"spl_id":["45263661-3ac2-6283-e063-6394a90ac1ec"],"spl_set_id":["c0a92873-0914-6a86-e053-2995a90ac41c"],"substance_name":["ASPIRIN","CAFFEINE"],"unii":["R16CO5Y76E","3G6A5W338E"],"upc":["0312843592186"]},"other_safety_information":["Other information ● save carton for full directions and warnings ● Store at room temperature. Avoid excessive heat above 40ºC (104ºF)."],"package_label_principal_display_panel":["Package Display 50 Count Carton Bayer® ASPIRIN (NSAID)/PAIN RELIEVER/FEVER REDUCER CAFFEINE/PAIN RELIEVER AID Headache FAST RELIEF AT THE SITE OF PAIN 50 COATED CAPLETS 500 MG Carton 50 count"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding, ask a health professional before use . It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery."],"purpose":[""],"questions":["Questions or comments? 1-800-331-4536 (Mon-Fri 9AM - 5PM EST)"],"set_id":"c0a92873-0914-6a86-e053-2995a90ac41c","spl_product_data_elements":["Bayer Headache Aspirin and caffeine CARNAUBA WAX HYPROMELLOSES PROPYLENE GLYCOL ASPIRIN ASPIRIN D&C YELLOW NO. 10 ALUMINUM LAKE POWDERED CELLULOSE TITANIUM DIOXIDE CAFFEINE CAFFEINE STARCH, CORN D&C RED NO. 30 TRIACETIN SHELLAC Bayer;Headache"],"spl_unclassified_section":["Drug Facts"],"version":"4","warnings":["Warnings Reye’s syndrome : Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert : Aspirin may cause a severe allergic reaction which may include: • hives • facial swelling • asthma (wheezing) • shock Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you ● are age 60 or older ● have had stomach ulcers or bleeding problems ● take a blood thinning (anticoagulant) or steroid drug ● take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) ● have 3 or more alcoholic drinks every day while using this product ● take more or for a longer time than directed Do not use ● if you are allergic to aspirin or any other pain reliever/fever reducer ● if you have ever had an allergic reaction to this product or any of its Ingredients Ask a doctor before use if ● stomach bleeding warning applies to you ● you have a history of stomach problems, such as heartburn ● you have high blood pressure, heart disease, liver cirrhosis, or kidney disease ● you are taking a diuretic ● you have asthma Ask a doctor or pharmacist before use if you are taking a prescription drug for ● gout ● diabetes ● arthritis Stop use and ask a doctor if an allergic reaction occurs. Seek medical help right away. you experience any of the following signs of stomach bleeding: feel faint vomit blood have bloody or black stools have stomach pain that does not get better pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur ringing in the ears or a loss of hearing occurs If pregnant or breast-feeding, ask a health professional before use . It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away."]}