{"active_ingredient":["Active ingredients (in each capsule) Active ingredients (in each capsule) Purposes Acetaminophen 250 mg Pain reliever/fever reducer Dextromethorphan hydrobromide 10 mg Cough suppressant Guaifenesin 200 mg Expectorant Phenylephrine hydrochloride 5 mg Nasal decongestant","Ask a doctor before use if you have liver disease heart disease high blood pressure thyroid disease diabetes difficulty in urination due to enlargement of the prostate gland persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis or emphysema cough with excessive phlegm (mucus)"],"active_ingredient_table":["
Active ingredients (in each capsule)Purposes
Acetaminophen 250 mgPain reliever/fever reducer
Dextromethorphan hydrobromide 10 mgCough suppressant
Guaifenesin 200 mgExpectorant
Phenylephrine hydrochloride 5 mgNasal decongestant
"],"ask_doctor_or_pharmacist":["Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin"],"do_not_use":["Do Not Use with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. if you have ever had an allergic reaction to this product or any of its ingredients in children under 12 years of age"],"dosage_and_administration":["Directions do not take more than the recommended dose adults and children 12 years and over: take 2 capsules with water every 4 hours. Do not exceed 12 capsules in 24 hours or as directed by a doctor. children under 12 years: do not use"],"effective_time":"20251204","id":"452662db-192f-a610-e063-6394a90a4a10","inactive_ingredient":["FD&C red #40, gelatin, glycerin, polyethylene glycol, povidone, propylene glycol, purified water, shellac, sodium hydroxide, sorbitol-sorbitan solution, titanium dioxide"],"indications_and_usage":["Uses temporarily relieves these symptoms due to a cold: · nasal congestion · sinus congestion and pressure · headache · minor aches and pains · cough · sore throat temporarily restores freer breathing through the nose helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive temporarily reduces fever"],"keep_out_of_reach_of_children":["Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms."],"openfda":{"application_number":["M013"],"brand_name":["Alka-Seltzer Plus Severe Sinus Cold and Cough Liquid Gels"],"generic_name":["ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, PHENYLEPHRINE HYDROCHLORIDE"],"is_original_packager":[true],"manufacturer_name":["Bayer HealthCare LLC."],"nui":["N0000193956","N0000008867","N0000009560"],"package_ndc":["0280-0507-20"],"pharm_class_epc":["Expectorant [EPC]"],"pharm_class_pe":["Decreased Respiratory Secretion Viscosity [PE]","Increased Respiratory Secretions [PE]"],"product_ndc":["0280-0507"],"product_type":["HUMAN OTC DRUG"],"route":["ORAL"],"rxcui":["1432488"],"spl_id":["452662db-192f-a610-e063-6394a90a4a10"],"spl_set_id":["0dba1329-5b0d-5688-e054-00144ff8d46c"],"substance_name":["ACETAMINOPHEN","DEXTROMETHORPHAN HYDROBROMIDE","GUAIFENESIN","PHENYLEPHRINE HYDROCHLORIDE"],"unii":["362O9ITL9D","9D2RTI9KYH","495W7451VQ","04JA59TNSJ"],"upc":["0016500559504"]},"other_safety_information":["Other information store at 15-25ºC (59-77ºF)"],"package_label_principal_display_panel":["PDP PDP PDP"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding, ask a health professional before use."],"purpose":["Purposes"],"questions":["Questions or comments? 1-800-986-0369 (Mon-Fri 9AM - 5PM EST)"],"set_id":"0dba1329-5b0d-5688-e054-00144ff8d46c","spl_product_data_elements":["Alka-Seltzer Plus Severe Sinus Cold and Cough Liquid Gels Acetaminophen, Dextromethorphan hydrobromide, Guaifenesin, Phenylephrine hydrochloride PROPYLENE GLYCOL WATER SHELLAC SODIUM HYDROXIDE TITANIUM DIOXIDE ACETAMINOPHEN ACETAMINOPHEN DEXTROMETHORPHAN HYDROBROMIDE DEXTROMETHORPHAN GUAIFENESIN GUAIFENESIN PHENYLEPHRINE HYDROCHLORIDE PHENYLEPHRINE FD&C RED NO. 40 GELATIN GLYCERIN POLYETHYLENE GLYCOL, UNSPECIFIED POVIDONE AS;SM"],"spl_unclassified_section":["Drug Facts"],"stop_use":["Stop use and ask a doctor if pain, cough, or nasal congestion gets worse or lasts more than 7 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur cough comes back or occurs with fever, rash or headache that lasts. These could be signs of a serious condition. nervousness, dizziness, or sleeplessness occurs"],"version":"8","warnings":["Warnings Liver warning : This product contains acetaminophen. Severe liver damage may occur if you take more than 12 capsules in 24 hours, which is the maximum daily amount for this product with other drugs containing acetaminophen 3 or more alcoholic drinks every day while using this product Allergy Alert: acetaminophen may cause severe skin or severe allergic reactions. Symptoms may include: skin reddening blisters rash hives facial swelling asthma (wheezing) shock If a skin or general allergic reaction occurs, stop use and seek medical help right away. Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly."],"when_using":["When using this product do not exceed recommended dosage"]}