{"active_ingredient":["Active ingredients (in each tablet) Aspirin 500 mg (NSAID)* Dextromethorphan hydrobromide 10 mg Doxylamine succinate 6.25 mg Phenylephrine bitartrate 7.8 mg *nonsteroidal anti-inflammatory drug"],"ask_doctor":["Ask a doctor before use if ● stomach bleeding warning applies to you ● you have a history of stomach problems, such as heartburn ● you have high blood pressure, heart disease, liver cirrhosis, or kidney disease ● you are taking a diuretic ● you have ● asthma ● diabetes ● thyroid disease ● glaucoma ● cough with excessive phlegm (mucus) ● a breathing problem such as emphysema or chronic bronchitis ● difficulty in urination due to enlargement of the prostate gland ● persistent or chronic cough such as occurs with smoking, asthma, or emphysema ● a sodium-restricted diet"],"ask_doctor_or_pharmacist":["Ask a doctor or pharmacist before use if you are ● taking a prescription drug for ● gout ● diabetes ● arthritis ● taking sedatives or tranquilizers"],"do_not_use":["Do not use ● if you are allergic to aspirin or any other pain reliever/fever reducer ● if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. ● if you have ever had an allergic reaction to this product or any of its ingredients ● in children under 12 years of age"],"dosage_and_administration":["Directions Directions ● adults and children 12 years and over: take 2 tablets fully dissolved in 4 oz of water at bedtime (may be taken every 4 to 6 hours). Do not exceed 8 tablets in 24 hours or as directed by a doctor. ● children under 12 years: do not use"],"effective_time":"20251204","id":"45267736-ecae-d911-e063-6294a90a98bc","inactive_ingredient":["Inactive ingredients acesulfame potassium, anhydrous citric acid, aspartame, calcium silicate, dimethicone, docusate sodium, flavors (natural & artificial), mannitol, povidone, sodium benzoate, sodium bicarbonate"],"indications_and_usage":["Uses Uses ● temporarily relieves these symptoms due to a cold: ● minor aches and pains ● headache ● runny nose ● sinus congestion and pressure ● cough ● sneezing ● sore throat ● nasal congestion ● temporarily reduces fever"],"keep_out_of_reach_of_children":["Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away"],"openfda":{"application_number":["M012"],"brand_name":["Alka-Seltzer Plus Cold Night"],"generic_name":["ASPIRIN, DEXTROMETHORPHAN HYDROBROMIDE, DOXYLAMINE SUCCINATE, PHENYLEPHRINE BITARTRATE"],"is_original_packager":[true],"manufacturer_name":["Bayer HealthCare LLC."],"nui":["N0000000160","N0000008836","M0001335","N0000175722","N0000175578","N0000008832"],"package_ndc":["0280-1545-20"],"pharm_class_cs":["Anti-Inflammatory Agents, Non-Steroidal [CS]"],"pharm_class_epc":["Nonsteroidal Anti-inflammatory Drug [EPC]","Platelet Aggregation Inhibitor [EPC]"],"pharm_class_moa":["Cyclooxygenase Inhibitors [MoA]"],"pharm_class_pe":["Decreased Prostaglandin Production [PE]","Decreased Platelet Aggregation [PE]"],"product_ndc":["0280-1545"],"product_type":["HUMAN OTC DRUG"],"route":["ORAL"],"rxcui":["1536503"],"spl_id":["45267736-ecae-d911-e063-6294a90a98bc"],"spl_set_id":["7588ea67-68a9-4dc0-e053-2991aa0aa471"],"substance_name":["ASPIRIN","DEXTROMETHORPHAN HYDROBROMIDE","DOXYLAMINE SUCCINATE","PHENYLEPHRINE BITARTRATE"],"unii":["R16CO5Y76E","9D2RTI9KYH","V9BI9B5YI2","27O3Q5ML57"],"upc":["0016500565000"]},"other_safety_information":["Other information Other information ● each tablet contains: sodium 476 mg ● Phenylketonurics: Contains Phenylalanine 5.6 mg Per Tablet ● store at room temperature. Avoid excessive heat."],"package_label_principal_display_panel":["Alka-Seltzer Plus ® Cold Night Lemon ASPIRIN ( NSAID ) / Pain Reliever-Fever Reducer Dextromethorphan HBr / Cough Suppressant Doxylamine Succinate / Antihistamine Phenylephrine Bitartrate / Nasal Decongestant Nasal Congestion Headache & Body Ache Cough Runny Nose Sore Throat 20 EFFERVESCENT TABLETS Carton 20 count"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding , ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery."],"purpose":["Purposes Pain reliever/fever reducer Cough suppressant Antihistamine Nasal decongestant"],"questions":["Questions or comments? Questions or comments? 1-800-986-0369 (Mon-Fri 9AM - 5PM EST)"],"set_id":"7588ea67-68a9-4dc0-e053-2991aa0aa471","spl_product_data_elements":["Alka-Seltzer Plus Cold Night Aspirin, Dextromethorphan hydrobromide, Doxylamine succinate, Phenylephrine bitartrate DIMETHICONE DOCUSATE SODIUM ASPIRIN ASPIRIN DEXTROMETHORPHAN HYDROBROMIDE DEXTROMETHORPHAN DOXYLAMINE SUCCINATE DOXYLAMINE PHENYLEPHRINE BITARTRATE PHENYLEPHRINE ACESULFAME POTASSIUM ANHYDROUS CITRIC ACID ASPARTAME CALCIUM SILICATE POVIDONE SODIUM BICARBONATE MANNITOL SODIUM BENZOATE ASP;NT"],"spl_unclassified_section":["Drug Facts"],"stop_use":["Stop use and ask a doctor if ● an allergic reaction occurs. Seek medical help right away. ● you experience any of the following signs of stomach bleeding ● feel faint ● vomit blood ● have bloody or black stools ● have stomach pain that does not get better ● pain, cough, or nasal congestion gets worse or lasts more than 7 days ● fever gets worse or lasts more than 3 days ● redness or swelling is present ● new symptoms occur ● ringing in the ears or a loss of hearing occurs ● cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition. ● nervousness, dizziness, or sleeplessness occurs"],"version":"6","warnings":["Warnings Reye’s syndrome : Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert: Aspirin may cause a severe allergic reaction which may include: ● hives ● facial swelling ● asthma (wheezing) ● shock Stomach bleeding warning : This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you ● are age 60 or older ● have had stomach ulcers or bleeding problems ● take a blood thinning (anticoagulant) or steroid drug ● take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) ● have 3 or more alcoholic drinks every day while using this product ● take more or for a longer time than directed Sore throat warning : If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly. Do not use to sedate children."],"when_using":["When using this product ● do not exceed recommended dosage ● may cause marked drowsiness ● avoid alcoholic drinks ● alcohol, sedatives, and tranquilizers may increase drowsiness ● be careful when driving a motor vehicle or operating machinery ● excitability may occur, especially in children"]}