{"active_ingredient":["Active ingredient Pyrithione zinc 1%"],"dosage_and_administration":["Directions for best results use at least twice a week or as directed by a doctor. for maximum dandruff control, use every time you shampoo. shake before use. wet hair, massage onto scalp, rinse, repeat if desired."],"effective_time":"20251218","id":"46409e50-bdcf-7c1f-e063-6294a90a1602","inactive_ingredient":["Inactive Ingredients Water, lauramidopropyl betaine, sodium cocoyl isethionate, sodium lauroyl sarcosinate, sodium chloride, argania spinosa kernel oil, zea mays (corn) silk extract, cocos nucifera (coconut) fruit extract, sodium citrate, fragrance, acrylates copolymer, polyquaternium-10, citric acid, sodium benzoate, sodium salicylate."],"indications_and_usage":["Uses helps prevent recurrence of flaking and itching associated with dandruff."],"keep_out_of_reach_of_children":["Keep this and all drugs out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"openfda":{"application_number":["M032"],"brand_name":["Head and Shoulders Supreme Detox and Hydrate"],"generic_name":["PYRITHIONE ZINC"],"is_original_packager":[true],"manufacturer_name":["The Procter & Gamble Manufacturing Company"],"package_ndc":["69423-343-35","69423-343-01"],"product_ndc":["69423-343"],"product_type":["HUMAN OTC DRUG"],"route":["TOPICAL"],"rxcui":["209884","1043244"],"spl_id":["46409e50-bdcf-7c1f-e063-6294a90a1602"],"spl_set_id":["8659218e-cb8d-bb44-e053-2a91aa0ae37b"],"substance_name":["PYRITHIONE ZINC"],"unii":["R953O2RHZ5"]},"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL - 350 mL Bottle Label head & shoulders ® PYRITHIONE ZINC DANDRUFF SCALP & HAIR SHAMPOO SUPREME DETOX & HYDRATE WITH ARGAN OIL & COCONUT WATER FREE FROM SULFATES PARABENS DYES PHOSPHATES SILICONES 11.8 FL OZ (350 mL) HS"],"purpose":["Purpose Anti-dandruff"],"questions":["Questions (or comments)? 1-800-723-9569"],"set_id":"8659218e-cb8d-bb44-e053-2a91aa0ae37b","spl_product_data_elements":["Head and Shoulders Supreme Detox and Hydrate Pyrithione Zinc CITRIC ACID MONOHYDRATE ARGAN OIL POLYQUATERNIUM-10 (30000 MPA.S AT 2%) SODIUM BENZOATE SODIUM COCOYL ISETHIONATE WATER SODIUM LAUROYL SARCOSINATE COCONUT OIL SODIUM SALICYLATE SODIUM CITRATE PYRITHIONE ZINC PYRITHIONE ZINC SODIUM CHLORIDE CORN SILK LAURAMIDOPROPYL BETAINE"],"spl_unclassified_section":["Drug Facts","Dist. by PROCTER & GAMBLE, CINCINNATI, OH 45202"],"stop_use":["Stop use and ask a doctor if condition worsens or does not improve after regular use of this product as directed."],"version":"8","warnings":["Warnings For external use only. When using this product avoid contact with eyes. If contact occurs, rinse eyes thoroughly with water. Stop use and ask a doctor if condition worsens or does not improve after regular use of this product as directed. Keep this and all drugs out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"when_using":["When using this product avoid contact with eyes. If contact occurs, rinse eyes thoroughly with water."]}