{"active_ingredient":["Active ingredient Adapalene 0.1% (retinoid) read consumer information leaflet"],"do_not_use":["Do not use on damaged skin (cuts, abrasions, eczema, sunburn) if you are allergic to adapalene or any of the ingredients in this product."],"dosage_and_administration":["Directions Adults and children 12 years of age and older: use once daily clean the skin gently and pat dry before applying the product cover the entire affected area with a thin layer. For example, if your acne is on the face, apply the product to the entire face. do not use more than one time a day. Applying more than directed will not provide faster or better results, but may worsen skin irritation. Children under 12 years of age: ask a doctor"],"effective_time":"20260107","id":"47d20188-59f7-d011-e063-6294a90a39fa","inactive_ingredient":["Inactive ingredients carbomer, disodium EDTA, phenoxyethanol, poloxamer 182, propylene glycol, sodium hydrixide, water"],"indications_and_usage":["Use For the treatment of acne"],"keep_out_of_reach_of_children":["Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"openfda":{"application_number":["ANDA215940"],"brand_name":["Proactiv MD Adapalene Acne Treatment"],"generic_name":["ADAPALENE"],"is_original_packager":[true],"manufacturer_name":["Alchemee, LLC"],"nui":["N0000175607","M0018962"],"package_ndc":["11410-958-45","11410-958-15"],"pharm_class_cs":["Retinoids [CS]"],"pharm_class_epc":["Retinoid [EPC]"],"product_ndc":["11410-958"],"product_type":["HUMAN OTC DRUG"],"route":["TOPICAL"],"rxcui":["307731"],"spl_id":["47d20188-59f7-d011-e063-6294a90a39fa"],"spl_set_id":["0a9b3755-c0db-4282-e063-6394a90a0c08"],"substance_name":["ADAPALENE"],"unii":["1L4806J2QF"],"upc":["0735786021429"]},"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL - 45 g Tube Box proactiv MD ® ADAPALENE GEL 0.1% ACNE TREATMENT PARABEN-FREE First FDA-Approved Over-the-Counter Topical Retinoid* for Acne Treatment Previously Available Only By Prescription Dermatologist Developed and Tested *Read carton and enclosed consumer information leaflet before using this product. Keep this carton and consumer information leaflet. They contain important information. NET WT 1.6 OZ (45 g) image 1"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding, ask a doctor before use."],"purpose":["Purpose Acne treatment"],"questions":["Questions? 1-800-950-4695"],"set_id":"0a9b3755-c0db-4282-e063-6394a90a0c08","spl_product_data_elements":["Proactiv MD Adapalene Acne Treatment Adapalene CARBOMER HOMOPOLYMER TYPE C (ALLYL PENTAERYTHRITOL CROSSLINKED) EDETATE DISODIUM POLOXAMER 182 PROPYLENE GLYCOL WATER SODIUM HYDROXIDE ADAPALENE ADAPALENE PHENOXYETHANOL"],"spl_unclassified_section":["Drug Facts","Distributed by Alchemee LLC, Hawthorne, NY 10532 Made in Canada of Foreign and Domestic Components"],"stop_use":["Stop use and ask a doctor if you become pregnant, or are planning to become pregnant, while using the product you have symptoms of an allergic reaction (such as itching, rash, hives, swelling of the lips, eyelids, and shortness of breath) irritation becomes severe you see no improvement after 3 months of once daily use"],"storage_and_handling":["Other information TAMPER EVIDENTl DONOT USE IF THE SEAL ON THE TUBE IS PUNCTURED OR VISIBLE. store at 20° to 25°C (68°- 77°F) (see USP Controlled Room Temperature). protect from freezing"],"version":"5","warnings":["Warnings For external use only Do not use on damaged skin (cuts, abrasions, eczema, sunburn) if you are allergic to adapalene or any of the ingredients in this product. If pregnant or breast-feeding, ask a doctor before use. When using this product limit sun exposure, including light from tanning beds, and use sunscreen when going outdoors do not wax to remove hair in areas where the product has been applied during the early weeks of use, your acne may appear to worsen before it improves (this is normal); continue using as directed, unless you get irritation that becomes severe irritation (redness, itching, dryness, burning) is more likely to occur: in the first few weeks of use if using more than one topical acne medication at a time but irritation usually lessens with continued use of this product it may take up to 3 months of once daily use to see results avoid product contact with eyes, lips, and mouth. If contact occurs, immediately flush the area with water. wash hands after use Stop use and ask a doctor if you become pregnant, or are planning to become pregnant, while using the product you have symptoms of an allergic reaction (such as itching, rash, hives, swelling of the lips, eyelids, and shortness of breath) irritation becomes severe you see no improvement after 3 months of once daily use Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"when_using":["When using this product limit sun exposure, including light from tanning beds, and use sunscreen when going outdoors do not wax to remove hair in areas where the product has been applied during the early weeks of use, your acne may appear to worsen before it improves (this is normal); continue using as directed, unless you get irritation that becomes severe irritation (redness, itching, dryness, burning) is more likely to occur: in the first few weeks of use if using more than one topical acne medication at a time but irritation usually lessens with continued use of this product it may take up to 3 months of once daily use to see results avoid product contact with eyes, lips, and mouth. If contact occurs, immediately flush the area with water. wash hands after use"]}