{"active_ingredient":["Active ingredient Sodium fluoride 0.243% (0.16% w/v fluoride ion)"],"dosage_and_administration":["Directions adults and children 2 yrs. & older: brush teeth thoroughly after meals or at least twice a day or use as directed by a dentist do not swallow to minimize swallowing use a pea-sized amount in children under 6 supervise children's brushing until good habits are established children under 2 yrs.: ask a dentist"],"effective_time":"20260108","id":"47e28064-055d-b334-e063-6394a90a3252","inactive_ingredient":["Inactive ingredients glycerin, hydrated silica, sodium hexametaphosphate, water, PEG-6, flavor, sodium lauryl sulfate, carrageenan, cocamidopropyl betaine, trisodium phosphate, sodium saccharin, xanthan gum, sucralose, mica, titanium dioxide"],"indications_and_usage":["Use helps protect against cavities"],"keep_out_of_reach_of_children":["Keep out of reach of children under 6 yrs. of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."],"openfda":{"application_number":["M021"],"brand_name":["Crest 3D White Brilliance Pro Enamel Protect"],"generic_name":["SODIUM FLUORIDE"],"is_original_packager":[true],"manufacturer_name":["The Procter & Gamble Manufacturing Company"],"package_ndc":["69423-750-03","69423-750-20","69423-750-39"],"product_ndc":["69423-750"],"product_type":["HUMAN OTC DRUG"],"route":["DENTAL"],"rxcui":["891775"],"spl_id":["47e28064-055d-b334-e063-6394a90a3252"],"spl_set_id":["f32d5708-8cb1-6499-e053-2995a90ac632"],"substance_name":["SODIUM FLUORIDE"],"unii":["8ZYQ1474W7"]},"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL - 110 g Tube Carton LARGE SIZE CREST 3D WHITE fluoride anticavity toothpaste enamel safe BRILLIANCE 100% MORE STAIN REMOVAL* ENAMEL PROTECT NT WT 3.9 OZ (110 g) Artwork"],"purpose":["Purpose Anticavity toothpaste"],"questions":["Questions? 1-800-492-7378"],"set_id":"f32d5708-8cb1-6499-e053-2995a90ac632","spl_product_data_elements":["Crest 3D White Brilliance Pro Enamel Protect Sodium Fluoride GLYCERIN TITANIUM DIOXIDE CARRAGEENAN SODIUM POLYMETAPHOSPHATE SODIUM PHOSPHATE, TRIBASIC, ANHYDROUS POLYETHYLENE GLYCOL 300 WATER HYDRATED SILICA COCAMIDOPROPYL BETAINE SACCHARIN SODIUM SODIUM LAURYL SULFATE XANTHAN GUM SUCRALOSE MICA SODIUM FLUORIDE FLUORIDE ION w/teal gel stripe"],"spl_unclassified_section":["Drug Facts","Dist. by Procter & Gamble, Cincinnati, OH 45202"],"version":"8","warnings":["Warning Keep out of reach of children under 6 yrs. of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."]}