{"active_ingredient":["ACTIVE INGREDIENT: Sodium fluoride 0.24% (0.13% w/v fluoride ion)"],"dosage_and_administration":["DIRECTIONS: adults and children 2 years of age and older: brush teeth thoroughly, preferably after each meal or at least twice a day, or as directed by a dentist or doctor. children under 6 years of age: instruct in good brushing and rinsing habits (to minimize swallowing). supervise children as necessary until capable of using without supervision. do not swallow children under 2 years of age: consult a dentist or doctor"],"effective_time":"20260331","id":"4aab2169-2fe1-4d9b-94a0-45724392e6bc","inactive_ingredient":["INACTIVE INGREDIENTS: water, hydrated silica, stabilized chlorine dioxide, sarkosyl (coconut derived), disodium hydrogen phosphate, cellulose gum, titanium dioxide, peppermint oil, sodium dihydrogen phosphate, sucralose, menthol crystals"],"indications_and_usage":["USE: Aids in the prevention of dental decay."],"keep_out_of_reach_of_children":["Keep out of reach of children under 6 years of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."],"openfda":{"application_number":["M021"],"brand_name":["CloSYS"],"generic_name":["SODIUM FLUORIDE"],"is_original_packager":[true],"manufacturer_name":["Rowpar Pharmaceuticals, Inc."],"package_ndc":["58578-0749-1","58578-0749-2","58578-0749-3","58578-0749-4"],"product_ndc":["58578-0749"],"product_type":["HUMAN OTC DRUG"],"route":["DENTAL","ORAL"],"rxcui":["416783"],"spl_id":["4aab2169-2fe1-4d9b-94a0-45724392e6bc"],"spl_set_id":["5f87abb7-0e9d-6369-e053-2a91aa0a2411"],"substance_name":["SODIUM FLUORIDE"],"unii":["8ZYQ1474W7"]},"package_label_principal_display_panel":["Principal Display Panel Closys ® Anticavity Fluoride Toothpaste SULFATE-FREE NEW LOOK! A CLEANER MOUTH A HEALTHIER YOU ® CLoSYS ® Anticavity Fluoride Toothpaste SENSITIVE TOOTHPASTE WITH FLUORIDE NON-IRRITATING SULFATE-FREE HELPS REBUILD WEAKEND TOOTH ENAMEL Protects Against Cavities Freshens Breath Non-Irritating Formula Gentle Mint 7oz (196g) NON-IRRITATING SULFATE-FREE pH balanced Fights Cavities Strengthens Enamel Closys ® Anticavity Fluoride Toothpaste SENSITIVE TOOTHPASTE WITH FLUORIDE NON-IRRITATING SULFATE-FREE HELPS REBUILD WEAKEND TOOTH ENAMEL Protects Against Cavities Freshens Breath Non-Irritating Formula Gentle Mint 7oz (196g) Closys ® Anticavity Fluoride Toothpaste SULFATE-FREE NEW LOOK! A CLEANER MOUTH A HEALTHIER YOU ® CLoSYS ® Anticavity Fluoride Toothpaste SENSITIVE TOOTHPASTE WITH FLUORIDE NON-IRRITATING SULFATE-FREE HELPS REBUILD WEAKEND TOOTH ENAMEL Protects Against Cavities Freshens Breath Non-Irritating Formula Gentle Mint 3.4oz (96g) NON-IRRITATING SULFATE-FREE pH balanced Fights Cavities Strengthens Enamel Closys ® Anticavity Fluoride Toothpaste SENSITIVE TOOTHPASTE WITH FLUORIDE NON-IRRITATING SULFATE-FREE HELPS REBUILD WEAKEND TOOTH ENAMEL Protects Against Cavities Freshens Breath Non-Irritating Formula Gentle Mint 3.4oz (96g)"],"purpose":["PURPOSE: Anticavity"],"questions":["Questions or comments? Call 1-800-643-3337"],"set_id":"5f87abb7-0e9d-6369-e053-2a91aa0a2411","spl_product_data_elements":["CloSYS Sodium Fluoride SUCRALOSE SODIUM PHOSPHATE, MONOBASIC, ANHYDROUS SODIUM PHOSPHATE, DIBASIC, ANHYDROUS CARBOXYMETHYLCELLULOSE WATER TITANIUM DIOXIDE HYDRATED SILICA CHLORINE DIOXIDE SODIUM FLUORIDE FLUORIDE ION PEPPERMINT OIL PEPPERMINT MENTHOL SODIUM LAUROYL SARCOSINATE 7 carton 3.4 carton"],"spl_unclassified_section":["Use of stabilized chlorine dioxide is protected under U.S. & foregin patents-see CloSYS.com/patents"],"version":"11","warnings":["WARNINGS:"]}