{"active_ingredient":["Active ingredients Carboxymethylcellulose sodium 0.5% Glycerin 1% Polysorbate 80 0.5%"],"dosage_and_administration":["Directions To open, TWIST AND PULL TAB TO REMOVE . Instill 1 or 2 drops in the affected eye(s) as needed and discard container."],"effective_time":"20220630","id":"4b93ea93-0dbb-4cb7-aae3-e48f04060bd1","inactive_ingredient":["Inactive ingredients Boric acid; butylated hydroxyl toluene; carbomer copolymer type A; castor oil; erythritol; flaxseed oil; levocarnitine; polyoxyl 40 stearate; purified water; and trehalose. May contain hydrochloric acid and/or sodium hydroxide (to adjust pH)."],"indications_and_usage":["Uses For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun. May be used as a protectant against further irritation."],"keep_out_of_reach_of_children":["Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"openfda":{"application_number":["M018"],"brand_name":["REFRESH Optive Mega-3"],"generic_name":["CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN AND POLYSORBATE 80"],"is_original_packager":[true],"manufacturer_name":["Allergan, Inc."],"nui":["N0000185370","N0000175629","N0000184306","N0000185001","M0000728","M0009417"],"package_ndc":["0023-7151-60","0023-5773-05","0023-5773-30","0023-4230-70"],"pharm_class_cs":["Allergens [CS]","Glycerol [CS]"],"pharm_class_epc":["Non-Standardized Chemical Allergen [EPC]"],"pharm_class_pe":["Increased Histamine Release [PE]","Cell-mediated Immunity [PE]","Increased IgG Production [PE]"],"product_ndc":["0023-4230","0023-7151","0023-5773"],"product_type":["HUMAN OTC DRUG"],"route":["OPHTHALMIC"],"rxcui":["1241471"],"spl_id":["4b93ea93-0dbb-4cb7-aae3-e48f04060bd1"],"spl_set_id":["c5f2b3f2-2071-45bd-a010-67f848bc0233"],"substance_name":["CARBOXYMETHYLCELLULOSE SODIUM","GLYCERIN","POLYSORBATE 80"],"unii":["K679OBS311","PDC6A3C0OX","6OZP39ZG8H"]},"other_safety_information":["Other information Use only if single-use container is intact. Use before expiration date marked on container. Store at 59°-77°F (15°-25°C). Store vials in the pouch until use. RETAIN THIS CARTON FOR FUTURE REFERENCE."],"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL NDC 0023-5773-30 PRESERVATIVE - FREE Refresh OPTIVE MEGA-3 ® Lubricant Eye Drops with HydroCell ® Fast-Acting Dry Eye Relief Formula Enhanced With Flaxseed Oil* 30 Vials 0.01 fl oz (0.4 mL) each Sterile PRINCIPAL DISPLAY PANEL NDC 0023-5773-30 PRESERVATIVE - FREE Refresh OPTIVE MEGA-3® Lubricant Eye Drops with HydroCell® Fast-Acting Dry Eye Relief Formula Enhanced With Flaxseed Oil* 30 Vials 0.01 fl oz (0.4 mL) each Sterile","PRINCIPAL DISPLAY PANEL NDC 0023-7151-60 VALUE SIZE 60 V IALS PRESERVATIVE - FREE Refresh OPTIVE MEGA-3 ® Lubricant Eye Drops W ith HydroCell ® Fast-Acting Dry Eye Relief Formula Enhanced With Flaxseed Oil* 60 Vials 0.01 fl oz (0.4 mL) each Sterile PRINCIPAL DISPLAY PANEL NDC 0023-7151-60 VALUE SIZE 60 VIALS PRESERVATIVE - FREE Refresh OPTIVE MEGA-3® Lubricant Eye Drops With HydroCell® Fast-Acting Dry Eye Relief Formula Enhanced With Flaxseed Oil* 60 Vials 0.01 fl oz (0.4 mL) each Sterile","PRINCIPAL DISPLAY PANEL NDC 0023-4230-70 7 0 V IALS PRESERVATIVE – FREE Refresh OPTIVE MEGA-3 ® Lubricant Eye Drops with HydroCell ® Fast-Acting Dry Eye Relief Enhanced with Flaxseed Oil* 7 0 Vials 0.01 fl oz (0.4 mL) each Sterile PRINCIPAL DISPLAY PANEL NDC 0023-4230-70 70 VIALS PRESERVATIVE – FREE Refresh OPTIVE MEGA-3® Lubricant Eye Drops with HydroCell® Fast-Acting Dry Eye Relief Enhanced with Flaxseed Oil* 70 Vials 0.01 fl oz (0.4 mL) each Sterile"],"purpose":["Purpose Eye lubricant Eye lubricant Eye lubricant"],"questions":["Questions or comments? 1.800.678.1605 refresheyedrops.com v2.0DFL5773"],"set_id":"c5f2b3f2-2071-45bd-a010-67f848bc0233","spl_product_data_elements":["REFRESH Optive Mega-3 Carboxymethylcellulose sodium, Glycerin and Polysorbate 80 CARBOXYMETHYLCELLULOSE SODIUM CARBOXYMETHYLCELLULOSE GLYCERIN GLYCERIN POLYSORBATE 80 POLYSORBATE 80 BORIC ACID BUTYLATED HYDROXYTOLUENE CARBOMER COPOLYMER TYPE A (ALLYL PENTAERYTHRITOL CROSSLINKED) CASTOR OIL ERYTHRITOL LINSEED OIL LEVOCARNITINE POLYOXYL STEARATE 40 WATER TREHALOSE SODIUM HYDROXIDE HYDROCHLORIC ACID REFRESH Optive Mega-3 Carboxymethylcellulose sodium, Glycerin and Polysorbate 80 CARBOXYMETHYLCELLULOSE SODIUM CARBOXYMETHYLCELLULOSE GLYCERIN GLYCERIN POLYSORBATE 80 POLYSORBATE 80 BORIC ACID BUTYLATED HYDROXYTOLUENE CARBOMER COPOLYMER TYPE A (ALLYL PENTAERYTHRITOL CROSSLINKED) CASTOR OIL ERYTHRITOL LINSEED OIL LEVOCARNITINE POLYOXYL STEARATE 40 WATER TREHALOSE SODIUM HYDROXIDE HYDROCHLORIC ACID REFRESH Optive Mega-3 Carboxymethylcellulose sodium, Glycerin and Polysorbate 80 CARBOXYMETHYLCELLULOSE SODIUM CARBOXYMETHYLCELLULOSE GLYCERIN GLYCERIN POLYSORBATE 80 POLYSORBATE 80 BORIC ACID BUTYLATED HYDROXYTOLUENE CARBOMER COPOLYMER TYPE A (ALLYL PENTAERYTHRITOL CROSSLINKED) CASTOR OIL ERYTHRITOL LINSEED OIL LEVOCARNITINE POLYOXYL STEARATE 40 WATER TREHALOSE SODIUM HYDROXIDE HYDROCHLORIC ACID"],"stop_use":["Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours."],"version":"9","warnings":["Warnings For external use only. To avoid contamination, do not touch tip of container to any surface. Do not reuse. Once opened, discard. Do not touch unit-dose tip to eye. If solution changes color, do not use. Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."]}