{"dosage_and_administration":["Directions: Use as Directed This prescription dentifrice is recommended for adults and pediatric patients six years and older. • Apply a thin ribbon of PRO-SYS Professional along the length of the toothbrush no more than \"pea size\" total dose. Brush for two minutes. • After brushing: ADULTS-Expectorate; do not eat or drink for 30 minutes. CHILDREN SIX YEARS OF AGE OR OLDER-Expectorate and rinse mouth with water. • Use at bedtime in place of your regular toothpaste or as directed by your dental professional."],"effective_time":"20260331","id":"4e5407aa-4a76-dac3-e063-6394a90a6f2a","inactive_ingredient":["Inactive Ingredients Sorbitol, Hydrated Silica, Water, Glycerin, PEG-12, Titanium Dioxide, Flavor, Sodium Lauryl Sulfate, Cellulose Gum, Xylitol, Sodium Benzoate, Disodium Phosphate, Sodium Saccharin"],"indications_and_usage":["Indications PRO-SYS Professional is a self-applied dentifrice for prevention of tooth decay, orthodontic decalcification and hypersensitivity."],"openfda":{"brand_name":["PRO-SYS"],"generic_name":["POTASSIUM NITRATE, SODIUM FLUORIDE"],"is_original_packager":[true],"manufacturer_name":["Benco Dental"],"package_ndc":["66975-778-01"],"product_ndc":["66975-778"],"product_type":["HUMAN PRESCRIPTION DRUG"],"route":["DENTAL","ORAL"],"rxcui":["637365"],"spl_id":["4e5407aa-4a76-dac3-e063-6394a90a6f2a"],"spl_set_id":["4c9c144a-f28e-756d-e063-6394a90a5971"],"substance_name":["POTASSIUM NITRATE","SODIUM FLUORIDE"],"unii":["RU45X2JN0Z","8ZYQ1474W7"]},"package_label_principal_display_panel":["Principal Display Panel PRO-SYS® PROFESSIONAL ANTI-CAVITY FLUORIDE TOOTHPASTE RX ONLY 5000 PPM 1.1% SODIUM FLUORIDE 5% POTASSIUM NITRATE SENSITIVE MINT, 4 OZ. (113G) BENCO DENTAL Tube Box"],"set_id":"4c9c144a-f28e-756d-e063-6394a90a5971","spl_product_data_elements":["PRO-SYS Potassium Nitrate, Sodium Fluoride POTASSIUM NITRATE NITRATE ION CELLULOSE GUM HYDRATED SILICA PEG-12 WATER DISODIUM PHOSPHATE SODIUM SACCHARIN SODIUM BENZOATE SORBITOL GLYCERIN XYLITOL SODIUM FLUORIDE FLUORIDE ION TITANIUM DIOXIDE SODIUM LAURYL SULFATE"],"version":"7","warnings":["Warnings Do not swallow For topical use only As with all medications, keep out of reach of children"]}