{"active_ingredient":["Active ingredients (in each tablet) Purposes Aspirin 325 mg (NSAID)*….………………….Pain reliever/fever reducer Chlorpheniramine maleate 2 mg……………….………...…Antihistamine Dextromethorphan hydrobromide 10 mg……………Cough suppressant Phenylephrine bitartrate 7.8 mg.......…………….….Nasal decongestant *nonsteroidal anti-inflammatory drug"],"ask_doctor":["Ask a doctor before use if stomach bleeding warning applies to you you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, or kidney disease you are taking a diuretic you have asthma diabetes thyroid disease glaucoma cough that is accompanied by excessive phlegm (mucus) persistent or chronic cough such as occurs with smoking, asthma, or emphysema a breathing problem such as emphysema or chronic bronchitis difficulty in urination due to enlargement of the prostate gland a sodium-restricted diet"],"ask_doctor_or_pharmacist":["Ask a doctor or pharmacist before use if you are taking a prescription drug for diabetes, gout, or arthritis taking sedatives or tranquilizers"],"do_not_use":["Do not use if you are allergic to aspirin or any other pain reliever/fever reducer if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product if you have ever had an allergic reaction to this product or any of its ingredients in children under 12 years of age"],"dosage_and_administration":["Directions ● adults and children 12 years and over: take 2 tablets fully dissolved in 4 oz of water every 4 hours. Do not exceed 8 tablets in 24 hours or as directed by a doctor. ● children under 12 years of age: do not use"],"effective_time":"20260409","id":"4f0c1b8e-3fb0-ccf2-e063-6394a90acd15","inactive_ingredient":["Inactive ingredients anhydrous citric acid, calcium silicate, dimethicone, flavors, mannitol, potassium bicarbonate, povidone, sodium bicarbonate, sucralose"],"indications_and_usage":["Uses temporarily relieves these symptoms due to a cold: minor aches and pains headache runny nose sinus congestion and pressure cough sneezing sore throat nasal congestion temporarily reduces fever"],"keep_out_of_reach_of_children":["Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away."],"openfda":{"application_number":["M012"],"brand_name":["Alka Seltzer Cold Cold and Congestion Severe Night Fast Dissolve"],"generic_name":["ASPIRIN, CHLORPHENIRAMINE MALEATE, DEXTROMETHORPHAN HYDROBROMIDE, PHENYLEPHRINE BITARTRATE"],"is_original_packager":[true],"manufacturer_name":["Bayer HealthCare LLC."],"nui":["N0000000160","N0000008836","M0001335","N0000175722","N0000175578","N0000008832"],"package_ndc":["0280-8265-24","0280-8265-16"],"pharm_class_cs":["Anti-Inflammatory Agents, Non-Steroidal [CS]"],"pharm_class_epc":["Nonsteroidal Anti-inflammatory Drug [EPC]","Platelet Aggregation Inhibitor [EPC]"],"pharm_class_moa":["Cyclooxygenase Inhibitors [MoA]"],"pharm_class_pe":["Decreased Prostaglandin Production [PE]","Decreased Platelet Aggregation [PE]"],"product_ndc":["0280-8265"],"product_type":["HUMAN OTC DRUG"],"route":["ORAL"],"rxcui":["1537029"],"spl_id":["4f0c1b8e-3fb0-ccf2-e063-6394a90acd15"],"spl_set_id":["4f0c1b8e-3fb1-ccf2-e063-6394a90acd15"],"substance_name":["ASPIRIN","CHLORPHENIRAMINE MALEATE","DEXTROMETHORPHAN HYDROBROMIDE","PHENYLEPHRINE BITARTRATE"],"unii":["R16CO5Y76E","V1Q0O9OJ9Z","9D2RTI9KYH","27O3Q5ML57"],"upc":["0016500598862"]},"other_safety_information":["Other information ● each tablet contains: potassium 80 mg; sodium 356 mg ● store between 20 o C to 25 o C (68 o F to 77 o F). Avoid excessive heat above 40 o C (104 o F)."],"package_label_principal_display_panel":["Carton 24 count PDP"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery."],"purpose":[""],"questions":["Questions or comments? 1-800-986-0369 (Mon-Fri 8AM - 8PM EST)"],"set_id":"4f0c1b8e-3fb1-ccf2-e063-6394a90acd15","spl_product_data_elements":["Alka Seltzer Cold Cold and Congestion Severe Night Fast Dissolve aspirin, chlorpheniramine maleate, dextromethorphan hydrobromide, phenylephrine bitartrate SODIUM BICARBONATE ASPIRIN ASPIRIN CHLORPHENIRAMINE MALEATE CHLORPHENIRAMINE DEXTROMETHORPHAN HYDROBROMIDE DEXTROMETHORPHAN PHENYLEPHRINE BITARTRATE PHENYLEPHRINE ANHYDROUS CITRIC ACID CALCIUM SILICATE DIMETHICONE MANNITOL POTASSIUM BICARBONATE POVIDONE SUCRALOSE ASP;NT"],"spl_unclassified_section":["Drug Facts"],"stop_use":["Stop use and ask a doctor if an allergic reaction occurs. Seek medical help right away. you experience any of the following signs of stomach bleeding feel faint vomit blood have bloody or black stools have stomach pain that does not get better pain, cough, or nasal congestion gets worse or lasts more than 7 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition. ringing in the ears or a loss of hearing occurs nervousness, dizziness, or sleeplessness occurs"],"version":"1","warnings":["Warnings Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert: Aspirin may cause a severe allergic reaction which may include: hives facial swelling asthma (wheezing) shock Stomach bleeding warning : This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directed Sore throat warning : If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea,or vomiting, consult a doctor promptly. Do not use to sedate children. Do not use if you are allergic to aspirin or any other pain reliever/fever reducer if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product if you have ever had an allergic reaction to this product or any of its ingredients in children under 12 years of age Ask a doctor before use if stomach bleeding warning applies to you you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, or kidney disease you are taking a diuretic you have asthma diabetes thyroid disease glaucoma cough that is accompanied by excessive phlegm (mucus) persistent or chronic cough such as occurs with smoking, asthma, or emphysema a breathing problem such as emphysema or chronic bronchitis difficulty in urination due to enlargement of the prostate gland a sodium-restricted diet Ask a doctor or pharmacist before use if you are taking a prescription drug for diabetes, gout, or arthritis taking sedatives or tranquilizers When using this product do not exceed recommended dosage may cause marked drowsiness alcohol, sedatives, and tranquilizers may increase drowsiness avoid alcoholic drinks be careful when driving a motor vehicle or operating machinery excitability may occur, especially in children Stop use and ask a doctor if an allergic reaction occurs. Seek medical help right away. you experience any of the following signs of stomach bleeding feel faint vomit blood have bloody or black stools have stomach pain that does not get better pain, cough, or nasal congestion gets worse or lasts more than 7 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition. ringing in the ears or a loss of hearing occurs nervousness, dizziness, or sleeplessness occurs If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away."],"when_using":["When using this product do not exceed recommended dosage may cause marked drowsiness alcohol, sedatives, and tranquilizers may increase drowsiness avoid alcoholic drinks be careful when driving a motor vehicle or operating machinery excitability may occur, especially in children"]}