{"active_ingredient":["Active Ingredient Menthol 8.0%"],"dosage_and_administration":["Directions Adults and children 2 years of age and older: apply directly onto affected area without the need to rub, massage or bandage repeat if necessary, but do not apply more than 3 to 4 times daily wash hands after use. Children under 2 years of age: do not use, consult a doctor"],"effective_time":"20260413","id":"4f5db354-ecdb-3529-e063-6394a90ae094","inactive_ingredient":["Inactive Ingredients boswellia serrata extract, carbomer, dimethylsulfone(MSM), eucalyptus oil, glucosamine sulfate, glycerin, peppermint oil, SD alcohol 39C, triethanolamine, water (USP)"],"indications_and_usage":["Uses For the temporary relief of minor aches and pains of muscles and joints associated with: simple backache arthritis strains bruises sprains"],"keep_out_of_reach_of_children":["Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"openfda":{"application_number":["M017"],"brand_name":["ActivICE"],"generic_name":["MENTHOL"],"is_original_packager":[true],"manufacturer_name":["Medline Industries, LP"],"package_ndc":["53329-992-69"],"product_ndc":["53329-992"],"product_type":["HUMAN OTC DRUG"],"route":["TOPICAL"],"rxcui":["727162","2264041"],"spl_id":["4f5db354-ecdb-3529-e063-6394a90ae094"],"spl_set_id":["8465b443-abe9-78fb-e053-2a91aa0ac1d8"],"substance_name":["MENTHOL"],"unii":["L7T10EIP3A"]},"other_safety_information":["Other information Store at room temperature."],"package_label_principal_display_panel":["Package Labels V5"],"pregnancy_or_breast_feeding":["If pregnant or breastfeeding, ask a health professional before use."],"purpose":["Purpose Topical Analgesic"],"recent_major_changes":["Updates to indications and usage section on April 2026"],"set_id":"8465b443-abe9-78fb-e053-2a91aa0ac1d8","spl_product_data_elements":["ActivICE menthol CARBOMER 940 ALCOHOL GLUCOSAMINE SULFATE TROLAMINE GLYCERIN BOSWELLIA SERRATA RESIN OIL DIMETHYL SULFONE PEPPERMINT OIL PEPPERMINT WATER MENTHOL MENTHOL EUCALYPTUS OIL"],"spl_unclassified_section":["Questions or comments? 1-800-MEDLINE (633-5463) Monday-Friday 9AM-5PM CST","Manufacturing Information Not made with natural rubber latex. Keep product upright. Handle with care. Protect from freezing, avoid excessive heat. www.medline.com © 2025 Medline Industries, LP Manufactured in USA for: Medline Industries, LP. Three Lakes Drive, Northfield, IL 60093 USA. 1-800-MEDLINE *This product is not manufactured or distributed by Reckitt Benckiser Group PLC and/or its subsidiaries, owner of the registered trademark Biofreeze®. REF: MDSAICEROLL"],"stop_use":["Stop use and ask a doctor if condition worsens, or if symptoms persist for more than 7 days or clear up and occur again within a few days redness is present excessive irritation of the skin develops"],"version":"7","warnings":["Warnings For external use only. Avoid contact with eyes. Flammable: keep away from fire or flame. When using this product use only as directed do not bandage tightly or use with heating pad do not apply to wounds or damaged skin Stop use and ask a doctor if condition worsens, or if symptoms persist for more than 7 days or clear up and occur again within a few days redness is present excessive irritation of the skin develops If pregnant or breastfeeding, ask a health professional before use. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"when_using":["When using this product use only as directed do not bandage tightly or use with heating pad do not apply to wounds or damaged skin"]}