{"active_ingredient":["Active ingredient (in each tablet) Buffered aspirin equal to 325 mg aspirin (NSAID) nonsteroidal anti-inflammatory drug (buffered with calcium carbonate, magnesium carbonate, and magnesium oxide)"],"ask_doctor":["Ask a doctor before use if stomach bleeding warning applies to you you have asthma you have a history of stomach problems, such as heartburn you are taking a diuretic you have high blood pressure, heart disease, liver cirrhosis, or kidney disease"],"ask_doctor_or_pharmacist":["Ask a doctor or pharmacist before use if you are taking a prescription drug for gout diabetes arthritis"],"do_not_use":["Do not use if you are allergic to aspirin or any other pain reliever/fever reducer if you have ever had an allergic reaction to this product or any of its ingredients"],"dosage_and_administration":["Directions drink a full glass of water with each dose adults and children 12 years and over: take 2 tablets every 4 hours not to exceed 12 tablets in 24 hours unless directed by a doctor children under 12 years: do not use unless directed by a doctor"],"effective_time":"20250225","id":"4f652a68-82a2-4c22-acc4-2cb28f96b358","inactive_ingredient":["Inactive ingredients anhydrous citric acid, corn starch, dibasic sodium phosphate anhydrous, hydrogenated vegetable oil, hypromellose, microcrystalline cellulose, polyethylene glycol, propylene glycol, shellac wax, simethicone, sodium lauryl sulfate, talc, titanium dioxide"],"indications_and_usage":["Uses temporarily relieves minor aches and pains associated with: headache toothache backache muscular aches headache minor pain of arthritis the common cold premenstrual & menstrual cramps temporarily reduces fever"],"keep_out_of_reach_of_children":["Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away."],"openfda":{"application_number":["M013"],"brand_name":["Bufferin Regular Strength Pain Relief"],"generic_name":["ASPIRIN"],"is_original_packager":[true],"manufacturer_name":["Genomma Lab USA"],"nui":["N0000000160","N0000008836","M0001335","N0000175722","N0000175578","N0000008832"],"package_ndc":["50066-610-13","50066-610-30"],"pharm_class_cs":["Anti-Inflammatory Agents, Non-Steroidal [CS]"],"pharm_class_epc":["Nonsteroidal Anti-inflammatory Drug [EPC]","Platelet Aggregation Inhibitor [EPC]"],"pharm_class_moa":["Cyclooxygenase Inhibitors [MoA]"],"pharm_class_pe":["Decreased Prostaglandin Production [PE]","Decreased Platelet Aggregation [PE]"],"product_ndc":["50066-610"],"product_type":["HUMAN OTC DRUG"],"route":["ORAL"],"rxcui":["212033","260847"],"spl_id":["4f652a68-82a2-4c22-acc4-2cb28f96b358"],"spl_set_id":["3543b2bf-1062-468a-a5dc-eabb2408af8c"],"substance_name":["ASPIRIN"],"unii":["R16CO5Y76E"]},"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL - 325 mg Table Bottle Carton Regular Strength Tough on pain. Gentler to your stomach.™ BUFFERIN ® BUFFERED ASPIRIN (NSAID) Pain Reliever Fever Reducer 30 Coated Tablets 325 mg each PRINCIPAL DISPLAY PANEL - 325 mg Table Bottle Carton"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery."],"purpose":["Purpose Pain reliever/fever reducer"],"questions":["Questions or comments? 1-877-994-3666"],"set_id":"3543b2bf-1062-468a-a5dc-eabb2408af8c","spl_product_data_elements":["Bufferin Regular Strength Pain Relief aspirin aspirin aspirin calcium carbonate magnesium carbonate magnesium oxide anhydrous citric acid Propylene glycol microcrystalline cellulose B"],"spl_unclassified_section":["Drug Facts","Distributed by: Genomma Lab USA Inc. Houston, TX 77027"],"stop_use":["Stop use and ask a doctor if an allergic reaction occurs. Seek medical help right away. you experience any of the following signs of stomach bleeding: feel faint have bloody or black stools vomit blood have stomach pain that does not get better ringing in the ears or a loss of hearing occurs pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur These could be signs of a serious condition."],"storage_and_handling":["Other information each tablet contains: calcium 35 mg and magnesium 40 mg store at 25°C (77°F); excursions permitted between 15°-30°C (59°-86°F) see end flap for expiration date and lot number"],"version":"2","warnings":["Warnings Reye's syndrome Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye's syndrome, a rare but serious illness. Allergy alert Aspirin may cause a severe allergic reaction, which may include: hives shock facial swelling asthma (wheezing) Stomach bleeding warning This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug are age 60 or older have 3 or more alcoholic drinks every day while using this product take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others] take more or for a longer time than directed Do not use if you are allergic to aspirin or any other pain reliever/fever reducer if you have ever had an allergic reaction to this product or any of its ingredients Ask a doctor before use if stomach bleeding warning applies to you you have asthma you have a history of stomach problems, such as heartburn you are taking a diuretic you have high blood pressure, heart disease, liver cirrhosis, or kidney disease Ask a doctor or pharmacist before use if you are taking a prescription drug for gout diabetes arthritis Stop use and ask a doctor if an allergic reaction occurs. Seek medical help right away. you experience any of the following signs of stomach bleeding: feel faint have bloody or black stools vomit blood have stomach pain that does not get better ringing in the ears or a loss of hearing occurs pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away."]}