{"active_ingredient":["Active Ingredients Histamine Dihydrochloride .025%"],"dosage_and_administration":["Dosage and Administration Apply no more than 3 to 4 times daily."],"effective_time":"20260521","id":"523333ee-ecce-bcf7-e063-6394a90aea60","inactive_ingredient":["Inactive Ingredients Aqua (Purified Water), Butylene Glycol, Emu Oil, Ethylhexylglycerin, Ethylhexyl Stearate, Helianthus Annuus (Sunflower) Seed Oil, C13-14 Isoparaffin, Laureth-7, Methylsulfonylmethane (MSM), Polyacrylamide, Potassium Sorbate, Sodium Polyacrylate, Tetrasodium EDTA, Tochopheryl Acetate (Vitamin E), Trideceth-6, Chondroitin Sulfate, Glucosamine Sulfate"],"indications_and_usage":["Indications and Usage Section For use by adults and children over 12 years. Apply a thin layer to pain site and massage until thoroughly absorbed into skin. Apply no more than 3 to 4 times daily. Children 12 years or younger consult a physician."],"keep_out_of_reach_of_children":["Keep out of reach of children Keep out of reach of children If swallowed, get medical help or contact a Poison Control Center right away"],"openfda":{"application_number":["M017"],"brand_name":["Arthritis Pain Relief Cream"],"generic_name":["HISTAMINE DIHYDROCHLORIDE"],"is_original_packager":[true],"manufacturer_name":["Sombra Cosmetics Inc."],"package_ndc":["61577-8120-4","61577-8120-5","61577-8120-9","61577-8120-8","61577-8120-2","61577-8120-1"],"product_ndc":["61577-8120"],"product_type":["HUMAN OTC DRUG"],"route":["TOPICAL"],"rxcui":["1091387"],"spl_id":["523333ee-ecce-bcf7-e063-6394a90aea60"],"spl_set_id":["523333ee-eccd-bcf7-e063-6394a90aea60"],"substance_name":["HISTAMINE DIHYDROCHLORIDE"],"unii":["3POA0Q644U"]},"package_label_principal_display_panel":["AD Arthritis 9oz Carton AD Arthritis 9oz Carton"],"purpose":["Purpose External Analgesic"],"questions":["Questions or Comments Call 1-888-600-4642"],"recent_major_changes":["Indications and Usage 12/2019 Submission Indications and Usage Section: For temporary relief of minor aches and pains of muscles and joints associated with arthritis 3/2026 Submission Indications and Usage Section: For use by adults and children over 12 years. Apply a thin layer to pain site and massage until thoroughly absorbed into skin. Apply no more than 3 to 4 times daily. Children 12 years or younger consult a physician."],"set_id":"523333ee-eccd-bcf7-e063-6394a90aea60","spl_product_data_elements":["Arthritis Pain Relief Cream Histamine Dihydrochloride POTASSIUM SORBATE HELIANTHUS ANNUUS (SUNFLOWER) SEED .ALPHA.-TOCOPHEROL ACETATE, DL- ETHYLHEXYL STEARATE TETRASODIUM EDTA SODIUM CARBONATE ETHYLHEXYLGLYCERIN HISTAMINE DIHYDROCHLORIDE HISTAMINE BUTYLENE GLYCOL DIMETHYL SULFONE SODIUM POLYACRYLATE (2500000 MW) PPG-1 TRIDECETH-6 C13-14 ISOPARAFFIN LAURETH-7 EMU OIL PHENOXYETHANOL SODIUM CHONDROITIN SULFATE (PORCINE; 5500 MW) WATER GLUCOSAMINE SULFATE POLYACRYLAMIDE (10000 MW)"],"stop_use":["Warnings For external use only. Do not use on wounds or damaged skin or if you are allergic to ingredients in the product. When using this product: avoid contact with eyes. If product gets into eyes, rinse thoroughly with water. Do not bandage tightly or use a heating pad. Stop use and ask doctor if: rash appears. condition worsens, if symptoms persist for more than 7 days, or if symptoms clear up and occur again within a few days."],"version":"1","warnings":["Warnings Section For external use only. Do not use on wounds or damaged skin or if you are allergic to ingredients in the product. When using this product: avoid contact with eyes. If product gets into eyes, rinse thoroughly with water. Do not bandage tightly or use a heating pad. Stop use and ask doctor if: rash appears. condition worsens, if symptoms persist for more than 7 days, or if symptoms clear up and occur again within a few days."],"when_using":["Uses For the temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backaches, strains & bruises.","Directions For use by adults and children over 12 years. Apply a thin layer to pain site and massage until thoroughly absorbed into skin. Apply no more than 3 to 4 times daily. Children 12 years or younger consult a physician."]}