{"active_ingredient":["Active ingredient Sodium Fluoride 0.24% (0.14% w/v fluoride ion)"],"dosage_and_administration":["Directions adults and children 2 years of age and older brush teeth thoroughly, preferably after each meal or at least twice a day, or as directed by a dentist or physician children 2 to 6 years use only a pea sized amount and supervise child's brushing and rinsing (to minimize swallowing) children under 2 years ask a dentist or physician"],"dosage_and_administration_table":["<table width=\"75%\" styleCode=\"Noautorules\"><col width=\"30%\" align=\"left\" valign=\"top\"/><col width=\"70%\" align=\"left\" valign=\"top\"/><tbody><tr styleCode=\"Botrule\"><td styleCode=\"Rrule\">adults and children 2 years of age and older</td><td>brush teeth thoroughly, preferably after each meal or at least twice a day, or as directed by a dentist or physician</td></tr><tr styleCode=\"Botrule\"><td styleCode=\"Rrule\">children 2 to 6 years</td><td>use only a pea sized amount and supervise child&apos;s brushing and rinsing (to minimize swallowing)</td></tr><tr><td styleCode=\"Rrule\">children under 2 years</td><td>ask a dentist or physician</td></tr></tbody></table>"],"effective_time":"20260909","id":"74d13300-bf75-4f8a-a1fa-a63c044a007c","inactive_ingredient":["Inactive ingredients Sorbitol, Water, Hydrated Silica, Flavor, Sodium Lauryl Sulfate, PEG-12, Sodium Saccharin, Cellulose Gum, Glycerin, Cocamidopropyl Betaine, Hydroxypropyl Methylcellulose, Blue 1, Titanium Dioxide."],"indications_and_usage":["Use helps protect against cavities"],"keep_out_of_reach_of_children":["Keep out of reach of children under 6 years of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."],"openfda":{"application_number":["M021"],"brand_name":["Colgate MaxFresh Knockout"],"generic_name":["SODIUM FLUORIDE"],"is_original_packager":[true],"manufacturer_name":["Colgate-Palmolive Company"],"package_ndc":["35000-214-95","35000-214-30","35000-214-17","35000-214-19"],"product_ndc":["35000-214"],"product_type":["HUMAN OTC DRUG"],"route":["DENTAL"],"rxcui":["416783"],"spl_id":["74d13300-bf75-4f8a-a1fa-a63c044a007c"],"spl_set_id":["0ffbb3a9-7bfa-4f6a-aef3-fde327a410c9"],"substance_name":["SODIUM FLUORIDE"],"unii":["8ZYQ1474W7"]},"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL - 178 g Tube Carton Colgate ® Anticavity Fluoride Toothpaste MaxFresh ® FRESHNESS POWERED BY ULTRAFREEZE 10X LONGER LASTING COOL FOR FRESH BREATH † KNOCKOUT ® FIGHTS BAD BREATH & FOOD AFTERTASTES* Mint Fusion ® WITH BREATH STRIPS NET WT 6.3 OZ (178g) Principal Display Panel - 178 g Tube Carton"],"purpose":["Purpose Anticavity"],"questions":["Questions? 1-800-468-6502"],"set_id":"0ffbb3a9-7bfa-4f6a-aef3-fde327a410c9","spl_product_data_elements":["Colgate MaxFresh Knockout SODIUM FLUORIDE SODIUM FLUORIDE FLUORIDE ION SORBITOL WATER HYDRATED SILICA SODIUM LAURYL SULFATE POLYETHYLENE GLYCOL 600 SACCHARIN SODIUM CARBOXYMETHYLCELLULOSE SODIUM, UNSPECIFIED GLYCERIN COCAMIDOPROPYL BETAINE HYPROMELLOSE, UNSPECIFIED FD&C BLUE NO. 1 TITANIUM DIOXIDE"],"spl_unclassified_section":["Drug Facts","DIST. BY: COLGATE-PALMOLIVE COMPANY, NEW YORK, NY 10022 USA"],"version":"3","warnings":["Warnings Keep out of reach of children under 6 years of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away."]}