{"active_ingredient":["Active ingredients Carboxymethylcellulose sodium 0.5% Glycerin 1% Polysorbate 80 0.5%"],"dosage_and_administration":["Directions Instill 1 or 2 drops in the affected eye(s) as needed."],"effective_time":"20220901","id":"82284b10-2578-4490-bb19-e38da030a102","inactive_ingredient":["Inactive ingredients Boric acid; carbomer copolymer type A; castor oil; erythritol; levocarnitine; purified water; PURITE® (stabilized oxychloro complex); and sodium hydroxide (to adjust pH)."],"indications_and_usage":["Uses For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun. May be used as a protectant against further irritation."],"keep_out_of_reach_of_children":["Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"openfda":{"application_number":["M018"],"brand_name":["REFRESH OPTIVE Advanced"],"generic_name":["CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80"],"is_original_packager":[true],"manufacturer_name":["Allergan, Inc."],"nui":["N0000185370","N0000175629","N0000184306","N0000185001","M0000728","M0009417"],"package_ndc":["0023-4307-03","0023-4307-10","0023-4307-20","0023-4307-02","0023-4307-15"],"pharm_class_cs":["Allergens [CS]","Glycerol [CS]"],"pharm_class_epc":["Non-Standardized Chemical Allergen [EPC]"],"pharm_class_pe":["Increased Histamine Release [PE]","Cell-mediated Immunity [PE]","Increased IgG Production [PE]"],"product_ndc":["0023-4307"],"product_type":["HUMAN OTC DRUG"],"route":["OPHTHALMIC"],"rxcui":["1241471"],"spl_id":["82284b10-2578-4490-bb19-e38da030a102"],"spl_set_id":["aaa943e4-7c38-4c5a-b7c0-5a656d8cafc0"],"substance_name":["CARBOXYMETHYLCELLULOSE SODIUM","GLYCERIN","POLYSORBATE 80"],"unii":["K679OBS311","PDC6A3C0OX","6OZP39ZG8H"]},"other_safety_information":["Other information Use only if tape seals on top and bottom flaps are intact. Use before expiration date marked on container. Discard 90 days after opening. Store at 59°-77°F (15°-25°C). RETAIN THIS CARTON FOR FUTURE REFERENCE."],"package_label_principal_display_panel":["Principal Display Panel NDC 0023-4307-10 Refresh OPTIVE® ADVANCED Lubricant Eye Drops with Hydrocell ® Triple-Action Relief For Dry Eyes 0.33 fl oz (10 mL) Sterile Principal Display Panel NDC 0023-4307-10 Refresh OPTIVE® ADVANCED Lubricant Eye Drops Triple-Action Relief For Dry Eyes 0.33 fl oz (10 mL) Sterile"],"purpose":["Purpose Eye lubricant Eye lubricant Eye lubricant"],"questions":["Questions or comments? 1.800.678.1605 refresh eyedrops .com v1.0DFL4307"],"set_id":"aaa943e4-7c38-4c5a-b7c0-5a656d8cafc0","spl_product_data_elements":["REFRESH OPTIVE Advanced carboxymethylcellulose sodium, glycerin, and polysorbate 80 CARBOXYMETHYLCELLULOSE SODIUM CARBOXYMETHYLCELLULOSE GLYCERIN GLYCERIN POLYSORBATE 80 POLYSORBATE 80 BORIC ACID CARBOMER COPOLYMER TYPE A CASTOR OIL ERYTHRITOL LEVOCARNITINE WATER SODIUM CHLORITE SODIUM HYDROXIDE"],"stop_use":["Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours."],"version":"16","warnings":["Warnings For external use only. To avoid contamination, do not touch tip of container to any surface. Replace cap after using. If solution changes color, do not use. Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."]}