{"active_ingredient":["Active ingredients Carboxymethylcellulose sodium 0.5% Glycerin 0.9%"],"dosage_and_administration":["Directions To open, TWIST AND PULL TAB TO REMOVE. Instill 1 or 2 drops in the affected eye(s) as needed and discard container. *Follow your eye doctor’s instructions if you are using this product after an eye surgery (e.g., LASIK) to relieve eye dryness and discomfort."],"effective_time":"20250822","id":"8e11bd05-1d8c-4abe-80d0-440cae2323b5","inactive_ingredient":["Inactive ingredients Boric acid; calcium chloride dihydrate; erythritol; levocarnitine; magnesium chloride hexahydrate; potassium chloride; purified water; sodium borate decahydrate; and sodium citrate dihydrate."],"indications_and_usage":["Uses For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun. May be used as a protectant against further irritation."],"keep_out_of_reach_of_children":["Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"openfda":{"application_number":["M018"],"brand_name":["Refresh Optive"],"generic_name":["CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN"],"is_original_packager":[true],"manufacturer_name":["Allergan, Inc."],"nui":["N0000185370","N0000175629","N0000184306","N0000185001","M0000728","M0009417"],"package_ndc":["0023-3416-05","0023-3416-30","0023-3416-60"],"pharm_class_cs":["Allergens [CS]","Glycerol [CS]"],"pharm_class_epc":["Non-Standardized Chemical Allergen [EPC]"],"pharm_class_pe":["Increased Histamine Release [PE]","Cell-mediated Immunity [PE]","Increased IgG Production [PE]"],"product_ndc":["0023-3416"],"product_type":["HUMAN OTC DRUG"],"route":["OPHTHALMIC"],"rxcui":["1100650"],"spl_id":["8e11bd05-1d8c-4abe-80d0-440cae2323b5"],"spl_set_id":["37e99aa8-02d6-4efb-a862-90bc7fcd5ca5"],"substance_name":["CARBOXYMETHYLCELLULOSE SODIUM","GLYCERIN"],"unii":["K679OBS311","PDC6A3C0OX"]},"other_safety_information":["Other information Use only if single-use container is intact. Use before expiration date marked on container. Store at 59°-77°F (15°-25°C). RETAIN THIS CARTON FOR FUTURE REFERENCE."],"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL NDC 0023-3416-30 PRESERVATIVE-FREE Refresh OPTIVE ® Lubricant Eye Drops Dual-Action Relief For Dry, Sensitive Eyes 30 Vials 0.01 fl oz (0.4 mL) each Sterile PRINCIPAL DISPLAY PANEL NDC 0023-3416-30 Preservative-free Refresh Optive® Lubricant Eye Drops Dual-Action Relief For Dry, Sensitive Eyes 30 Vials 0.01 fl oz (0.4 mL) each Sterile"],"purpose":["Purpose Eye lubricant Eye lubricant"],"questions":["Questions or comments? 1.800.678.1605 refresh eyedrops .com v2.0DFL3416 Phone"],"set_id":"37e99aa8-02d6-4efb-a862-90bc7fcd5ca5","spl_product_data_elements":["Refresh Optive Carboxymethylcellulose Sodium, Glycerin Carboxymethylcellulose Sodium Carboxymethylcellulose Glycerin Glycerin Boric Acid Calcium Chloride Erythritol Levocarnitine Magnesium Chloride potassium chloride water SODIUM BORATE trisodium citrate dihydrate"],"stop_use":["Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours."],"version":"11","warnings":["Warnings For external use only. To avoid contamination, do not touch tip of container to any surface. Do not reuse. Once opened, discard. Do not touch unit-dose tip to eye . If solution changes color or becomes cloudy , do not use. Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."]}