{"active_ingredient":["Active ingredients Carboxymethylcellulose sodium 0.5% Glycerin 0.9%"],"dosage_and_administration":["Directions Prior to first use, please read the “Instructions For Use” inside this carton. Instill 1 or 2 drops in the affected eye(s) as needed."],"effective_time":"20250915","id":"b6ddb19b-f29a-4a65-ac95-33420c2bd4bf","inactive_ingredient":["Inactive ingredients Boric acid; calcium chloride dihydrate; erythritol; levocarnitine; magnesium chloride hexahydrate; potassium chloride; purified water; sodium borate decahydrate; sodium citrate dihydrate; sodium hyaluronate, and trehalose. May contain hydrochloric acid and/or sodium hydroxide (to adjust pH)."],"indications_and_usage":["Uses For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun. May be used as a protectant against further irritation."],"keep_out_of_reach_of_children":["Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"openfda":{"application_number":["M018"],"brand_name":["Refresh Relieva PF Xtra"],"generic_name":["CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN"],"is_original_packager":[true],"manufacturer_name":["Allergan, Inc."],"nui":["N0000185370","N0000175629","N0000184306","N0000185001","M0000728","M0009417"],"package_ndc":["0023-3782-10","0023-3782-35","0023-3782-50","0023-3782-20"],"pharm_class_cs":["Allergens [CS]","Glycerol [CS]"],"pharm_class_epc":["Non-Standardized Chemical Allergen [EPC]"],"pharm_class_pe":["Increased Histamine Release [PE]","Cell-mediated Immunity [PE]","Increased IgG Production [PE]"],"product_ndc":["0023-3782"],"product_type":["HUMAN OTC DRUG"],"route":["OPHTHALMIC"],"rxcui":["1100650"],"spl_id":["b6ddb19b-f29a-4a65-ac95-33420c2bd4bf"],"spl_set_id":["b51b8a75-8faa-430f-8f7e-ee58d3d13f2e"],"substance_name":["CARBOXYMETHYLCELLULOSE SODIUM","GLYCERIN"],"unii":["K679OBS311","PDC6A3C0OX"]},"other_safety_information":["Other information Use only if tape seals on top and bottom flaps are intact. Use before expiration date marked on container. Discard 90 days after opening. Store at 59°-77°F (15°-25°C). RETAIN THIS CARTON AND THE INSERT FOR FUTURE REFERENCE."],"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL NDC 0023-3782-10 PRESERVATIVE-FREE Refresh ® R ELIEVA ® PF Xtra Lubricant Eye Drops With HydroCell ® Fast-Acting Relief Hydrates & Protects Dry, Sensitive Eyes 0.33 fl oz (10 mL) Sterile PRINCIPAL DISPLAY PANEL NDC 0023-3782-10 PRESERVATIVE-FREE Refresh® RELIEVA® PF Xtra Lubricant Eye Drops With HydroCell® Fast-Acting Relief Hydrates & Protects Dry, Sensitive Eyes 0.33 fl oz (10 mL) Sterile"],"purpose":["Purpose Eye lubricant Eye lubricant"],"questions":["Questions or comments? 1.800.678.1605 refresh eyedrops .com v2.0DFL3782"],"set_id":"b51b8a75-8faa-430f-8f7e-ee58d3d13f2e","spl_product_data_elements":["Refresh Relieva PF Xtra Carboxymethylcellulose Sodium and Glycerin CARBOXYMETHYLCELLULOSE SODIUM CARBOXYMETHYLCELLULOSE GLYCERIN GLYCERIN BORIC ACID CALCIUM CHLORIDE ERYTHRITOL LEVOCARNITINE MAGNESIUM CHLORIDE POTASSIUM CHLORIDE WATER SODIUM BORATE TRISODIUM CITRATE DIHYDRATE HYALURONATE SODIUM TREHALOSE HYDROCHLORIC ACID SODIUM HYDROXIDE"],"stop_use":["Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours."],"version":"5","warnings":["Warnings For external use only. To avoid contamination, do not touch tip of contai ner to any surface. Replace cap after using. If solution changes color or becomes cloudy , do not use. Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."]}