{"abuse":["Abuse"],"adverse_reactions":["ADVERSE REACTIONS Side effects that have been reported with glucosamine and chondroitin are mainly mild gastrointestinal complaints, such as heartburn, epigastric distress, nausea and diarrhea. No sulfa allergic reactions or other allergic reactions have been reported."],"carcinogenesis_and_mutagenesis_and_impairment_of_fertility":["Carcinogenesis, Mutagenesis, Impairment of Fertility"],"clinical_pharmacology":["CLINICAL PHARMACOLOGY Early studies using high-molecular-weight chondroitin sulfate that there was no significant absorption; recent studies suggest that there is probably significant absorption of low-molecular-weight chondroitin sulfate. Absorption appears to occur from the stomach and small intestine. Studies of the pharmacokinetics of orally administered chondroitin sulfate are ongoing. The pharmacokinetics of glucosamine are derived primarily from animal studies. About 90% of glucosamine administered orally as a glucosamine salt gets absorbed from the small intestine, and there it is transported via the portal circulation to the liver. It appears that a significant fraction of the ingested glucosamine is catabolized by first-pass metabolism in the liver. Free glucosamine is not detected in the serum after oral intake, and it is not presently known how much of an ingested dose is taken up in the joints in humans. Evidence suggests that sequestering pathophysiological carbonyl agents may help to ameliorate various etiological aspects of a range of chronic health conditions. Primorine ® - a proprietary blend of para-aminobenzoic acid, vitamin E, and alpha-lipoic acid - is a novel carbonyl-trapping combination."],"contraindications":["CONTRAINDICATIONS There are no known contraindications to supplementation with either glucosamine or chondroitin."],"controlled_substance":["Controlled Substance"],"dependence":["Dependence"],"description":["DESCRIPTION Each oblong white tablet contains: Active Ingredients Chondroitin Sulfate 300 mg Glucosamine 400 mg Primorine® 425 mg (a proprietary blend of para-aminobenzoic acid, vitamin E, and alpha-lipoic acid. In humans, chondroitin sulfate is found in cartilage, one, cornea, skin, and the arterial wall. It belongs to the GAG family and is made up o linear repeating units containing D-galactosamine and D-glucuronic acid. The molecular weight of chondroitin sulfate ranges from 5,000 to 50,000 daltons and contains about 15 to 150 basic units of D-galactosamine and D-glucoronic acid. Inactive Ingredients: Microcrystalline cellulose, stearic acid, croscarmellose sodium, silicon dioxide, magnesium stearate, hypromellose, hydroxypropyl cellulose, water."],"dosage_and_administration":["DOSAGE AND ADMINISTRATION The usual adult dose of RELAMINE ® is two tablets twice daily or as directed by a physician."],"drug_abuse_and_dependence":["DRUG ABUSE AND DEPENDENCE Controlled Substance Abuse Dependence"],"drug_and_or_laboratory_test_interactions":["Drug/Laboratory Test Interactions"],"drug_interactions":["Interactions Drug and Food Interactions: Glucosamine may increase insulin resistance and consequently affect glucose tolerance. Individuals with diabetes who, under medical advisement, decide to use glucosamine supplements will need to monitor their blood glucose and my need to adjust the doses of the medications they take to control blood glucose. This need to be done under medical supervision. No other drug, nutritional supplement, food, or herb interaction is known. There are no known drug, nutrient, food or herb interactions with chondroitin. Chitosan may form complexes with chondroitin sulfate, decreasing its absorption. Therefore, chondroitin sulfate should not be used concomitantly with chitosan. Drug/Laboratory Test Interactions"],"effective_time":"20110321","general_precautions":["General"],"geriatric_use":["Geriatric Use"],"how_supplied":["HOW SUPPLIED Available as an oblong white tablet. Debossed with \"ZYL\" on one side and \"200\" on the other side. Supplied in bottles of 120 tablets. NDC# 23594-200-10 Store at controlled room temperature between 15 o - 30 o C (59 o - 86 o F) (See USP). Protect from light and moisture. Dispense in original light-resistant container with child-resistant closure."],"id":"be89c96d-7760-4091-b994-76176c6ca061","indications_and_usage":["INDICATIONS AND USAGE RELAMINE ® tablets are indicated for the distinct nutritional requirements of individuals under a physician's treatment for ostearthritis."],"information_for_patients":["Information for Patients RELAMINE ® is a medical food for use only under the direction and supervision of a licensed physician."],"labor_and_delivery":["Labor and Delivery"],"laboratory_tests":["Laboratory Tests"],"nonteratogenic_effects":["Nonteratogenic Effects"],"nursing_mothers":["Nursing Mothers"],"openfda":{},"overdosage":["OVERDOSAGE"],"package_label_principal_display_panel":["PACKAGE/LABEL PRINCIPAL DISPLAY PANEL CONTAINER LABEL 7062 CL"],"pediatric_use":["Pediatric Use"],"precautions":["PRECAUTIONS Glucosamine may increase insulin resistance. Glucosamine increases insulin resistance in normal and experimentally diabetic animals. In these animals, intravenous glucosamine significantly decreases the rate of glucose uptake in skeletal muscle. In animals given oral glucosamine, this is not observed. Patients with type 2 diabetes or those who are overweight and have problems with glucose tolerance should have their blood sugar levels carefully monitored if they use glucosamine supplements. Because of insufficient safety data, children, pregnant women, and nursing mothers should avoid using glucosamine. Due to the theoretical possibility that chondroitin sulfate may have antithrombotic activity, those taking warfarin and those with hemophilia should exercise caution in its use. Those who need to restrict their salt intake should, if they use chondroitin sulfate, use salt-free preparations. General Information for Patients RELAMINE ® is a medical food for use only under the direction and supervision of a licensed physician. Laboratory Tests Interactions Drug and Food Interactions: Glucosamine may increase insulin resistance and consequently affect glucose tolerance. Individuals with diabetes who, under medical advisement, decide to use glucosamine supplements will need to monitor their blood glucose and my need to adjust the doses of the medications they take to control blood glucose. This need to be done under medical supervision. No other drug, nutritional supplement, food, or herb interaction is known. There are no known drug, nutrient, food or herb interactions with chondroitin. Chitosan may form complexes with chondroitin sulfate, decreasing its absorption. Therefore, chondroitin sulfate should not be used concomitantly with chitosan. Drug/Laboratory Test Interactions Carcinogenesis, Mutagenesis, Impairment of Fertility Pregnancy Teratogenic Effects Nonteratogenic Effects Labor and Delivery Nursing Mothers Pediatric Use Geriatric Use"],"pregnancy":["Pregnancy Teratogenic Effects Nonteratogenic Effects"],"set_id":"be89c96d-7760-4091-b994-76176c6ca061","spl_product_data_elements":["RELAMINE AMINOBENZOIC ACID, ALPHA LIPOIC ACID,ALPHA.-TOCOPHEROL SUCCINATE, GLUCOSAMINE SULFATE, CHONDROITIN SULFATE AMINOBENZOIC ACID AMINOBENZOIC ACID ALPHA LIPOIC ACID ALPHA LIPOIC ACID .ALPHA.-TOCOPHEROL SUCCINATE, D- ALPHA-TOCOPHEROL GLUCOSAMINE SULFATE GLUCOSAMINE CHONDROITIN SULFATE (BOVINE) CONDOLIASE SILICON DIOXIDE CELLULOSE, MICROCRYSTALLINE CROSCARMELLOSE SODIUM STEARIC ACID MAGNESIUM STEARATE ZYL;200"],"teratogenic_effects":["Teratogenic Effects"],"version":"1","warnings":["WARNINGS"]}