{"adverse_reactions":["ADVERSE REACTIONS Developing teeth of children under 6 years of age may become permanently discolored if excessive amounts are repeatedly swallowed. The following adverse reactions are possible in individuals hypersensitive to fluoride: eczema, atopic dermatitis, urticaria, gastric distress, headache, and weakness."],"contraindications":["CONTRAINDICATIONS Hypersensitivity to fluoride. Acidulated Phosphate Fluoride should not be used for patients with porcelain, composite restorations and sealants."],"dosage_and_administration":["DOSAGE AND ADMINISTRATION Shake can thoroughly for at least 30 seconds before each use. Hold can completely upside down to dispense. Point can toward applicator tray and slowly press nozzle to fill tray. Use one press per arch (foam will expand slightly to fill the tray). Dry tooth surface and insert tray(s) in mouth. Have patient bite down for 1 minute or up to 4 minutes. Remove tray(s) and have patient expectorate excess. Instruct patient not to eat, drink, or rinse for 30 minutes. Figure RECOMMENDED FREQUENCY Not to exceed 4 treatments per year."],"effective_time":"20221107","how_supplied":["HOW SUPPLIED 2.73% sodium fluoride (1.23% fluoride ion) foam supplied in 4.4 fl.oz. aerosol container Store at 20°C - 25°C (68°F - 77°F); excursions permitted between 15°C - 30°C (59°F - 86°F) [See USP Controlled room temperature.]"],"id":"dc22f86a-7d06-47f7-8506-1c5124b89389","indications_and_usage":["INDICATIONS AND USAGE For topical application to aid in the protection against dental caries."],"openfda":{},"overdosage":["OVERDOSAGE If treatment dose is swallowed (or less than 100 mg of Fluoride ion) administer milk, limewater, or calcium-type antacid. In case of larger doses swallowed (more than 100 mg of Fluoride ion) administer ipecac syrup emetic and immediately seek medical help. Overdose symptoms include nausea, vomiting, diarrhea, and abdominal pain."],"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL - Bubble Gum bubble gum","PRINCIPAL DISPLAY PANEL - Orange Vanilla Orange Vanilla","PRINCIPAL DISPLAY PANEL - Spearmint spearmint","PRINCIPAL DISPLAY PANEL - Strawberry strawberry"],"set_id":"115ffee9-1398-4fe3-986e-433e0989b78b","spl_product_data_elements":["NUPRO 60 Second Fluoride Foam Sodium Fluoride SODIUM FLUORIDE FLUORIDE ION WATER APAFLURANE BENZALDEHYDE OLETH-3 PHOSPHATE POLYETHYLENE GLYCOL 400 CETYL PHOSPHATE STEARIC ACID CETYL ALCOHOL SODIUM METHYL COCOYL TAURATE SODIUM PHOSPHATE, MONOBASIC, MONOHYDRATE SACCHARIN SODIUM SODIUM BENZOATE NUPRO 60 Second Fluoride Foam Sodium Fluoride SODIUM FLUORIDE FLUORIDE ION WATER APAFLURANE BENZALDEHYDE OLETH-3 PHOSPHATE POLYETHYLENE GLYCOL 400 CETYL PHOSPHATE STEARIC ACID CETYL ALCOHOL SODIUM METHYL COCOYL TAURATE SODIUM PHOSPHATE, MONOBASIC, MONOHYDRATE SACCHARIN SODIUM SODIUM BENZOATE NUPRO 60 Second Fluoride Foam Sodium Fluoride SODIUM FLUORIDE FLUORIDE ION WATER APAFLURANE BENZALDEHYDE OLETH-3 PHOSPHATE POLYETHYLENE GLYCOL 400 CETYL PHOSPHATE STEARIC ACID CETYL ALCOHOL SODIUM METHYL COCOYL TAURATE SODIUM PHOSPHATE, MONOBASIC, MONOHYDRATE SACCHARIN SODIUM SODIUM BENZOATE NUPRO 60 Second Fluoride Foam Sodium Fluoride SODIUM FLUORIDE FLUORIDE ION WATER APAFLURANE BENZALDEHYDE OLETH-3 PHOSPHATE POLYETHYLENE GLYCOL 400 CETYL PHOSPHATE STEARIC ACID CETYL ALCOHOL SODIUM METHYL COCOYL TAURATE SODIUM PHOSPHATE, MONOBASIC, MONOHYDRATE SACCHARIN SODIUM SODIUM BENZOATE"],"spl_unclassified_section":["Rx Only","Manufactured for: DENTSPLY Professional 1301 Smile Way York, PA 17404 1-800-989-8826 Made in U.S.A.","Danger: Extremely flammable aerosol. Contains gas under pressure: may explode if heated. May cause an allergic skin reaction. Causes serious eye damage. SAFETY DATA SHEET is available on our website, www.dentsplysirona.com, or by contacting Customer Service at 1-800-989-8826. warnings images"],"storage_and_handling":["Store at 20°C - 25°C (68°F - 77°F); excursions permitted between 15°C - 30°C (59°F - 86°F) [See USP Controlled room temperature.]"],"version":"4","warnings_and_cautions":["PRECAUTIONS Do not swallow. Keep out of reach of children. Safety and effectiveness below 3 years of age has not been established. There have been no long term animal studies with this product to evaluate carcinogenic, mutagenic, or impairment of fertility potential. Laboratory studies have indicated that repeated use of Acidulated Phosphate Fluoride may dull porcelain, composite restorations, and sealants."]}