{"dosage_and_administration":["DOSAGE AND ADMINISTRATION Apply 2 pumps (1g) to affected areas twice a day or as directed by a physician. Always use sunscreen protection. (See enclosed package insert for full prescribing information.)"],"effective_time":"20220421","id":"dd2fe1d6-cadc-4299-e053-2995a90a4f3e","openfda":{"brand_name":["ZO Skin Health Pigment Control plus Brightening Creme Hydroquinone plus Vitamin C"],"generic_name":["HYDROQUINONE"],"is_original_packager":[true],"manufacturer_name":["ZO Skin Health, Inc."],"nui":["N0000175851","N0000175854","N0000175850"],"package_ndc":["42851-035-81"],"pharm_class_epc":["Melanin Synthesis Inhibitor [EPC]"],"pharm_class_moa":["Melanin Synthesis Inhibitors [MoA]"],"pharm_class_pe":["Depigmenting Activity [PE]"],"product_ndc":["42851-035"],"product_type":["HUMAN PRESCRIPTION DRUG"],"route":["TOPICAL"],"spl_id":["dd2fe1d6-cadc-4299-e053-2995a90a4f3e"],"spl_set_id":["d7bfa71b-ddce-437e-abf9-2837af82c54d"],"substance_name":["HYDROQUINONE"],"unii":["XV74C1N1AE"]},"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL - 81 mL Bottle Carton ZO ® SKIN HEALTH BY ZEIN OBAGI MD PIGMENT CONTROL + BRIGHTENING CRÈME 4% Hydroquinone + 20% Vitamin C RX ONLY NDC 42851-035-81 81 mL / 2.7 Fl. Oz. PRINCIPAL DISPLAY PANEL - 81 mL Bottle Carton"],"set_id":"d7bfa71b-ddce-437e-abf9-2837af82c54d","spl_product_data_elements":["ZO Skin Health Pigment Control plus Brightening Creme Hydroquinone plus Vitamin C Hydroquinone ASCORBIC ACID ASCORBYL PALMITATE MEDIUM-CHAIN TRIGLYCERIDES CAPRYLYL TRISILOXANE CETYL PEG/PPG-10/1 DIMETHICONE (HLB 2) DIMETHICONE DIMETHICONE CROSSPOLYMER (450000 MPA.S AT 12% IN CYCLOPENTASILOXANE) DIETHYLENE GLYCOL MONOETHYL ETHER SUNFLOWER OIL OLEYL ALCOHOL PLUKENETIA VOLUBILIS SEED OIL VITAMIN A PALMITATE ROSEMARY SQUALANE TOCOPHEROL .ALPHA.-TOCOPHEROL ACETATE ZANTHOXYLUM BUNGEANUM FRUIT HYDROQUINONE HYDROQUINONE"],"spl_unclassified_section":["ACTIVE INGREDIENT Hydroquinone 4%","INACTIVE INGREDIENTS Ascorbic Acid, Ascorbyl Palmitate, Caprylic/Capric Triglyceride, Caprylyl Methicone, Cetyl PEG/PPG-10/1 Dimethicone, Dimethicone, Dimethicone Crosspolymer, Ethoxydiglycol, Helianthus Annuus (Sunflower) Seed Oil, Oleyl Alcohol, Plukenetia Volubilis Seed Oil, Retinyl Palmitate, Rosmarinus Officinalis (Rosemary) Leaf Extract, Squalane, Tocopherol, Tocopheryl Acetate, Zanthoxylum Bungeanum Fruit Extract.","Bleaches and corrects the most severe and advanced forms of hyperpigmentation in the skin with 4% hydroquinone and 20% vitamin C.","Dist. by ZO Skin Health, Inc. Irvine, CA 92618 Made in USA with US & imported materials zoskinhealth.com | 906000"],"storage_and_handling":["STORAGE Store at controlled room temperature: 15°-30°C (59°-86°F), away from direct sunlight."],"version":"3","warnings":["WARNINGS Keep out of reach of children. For external use only. Avoid contact with the eyes. Some users may experience a mild skin irritation. If skin irritation becomes severe, stop use and consult a physician. Do not use on children under 12 years of age unless directed by a physician. If swallowed, get medical help or contact a Poison Control Center right away."]}