{"active_ingredient":["Active ingredients - Nighttime (in each 30 mL dose cup) Acetaminophen 650 mg Dextromethorphan HBr 30 mg Doxylamine succinate 12.5 mg","Active ingredients - Daytime (in each 15 mL tablespoon) Acetaminophen 325 mg Dextromethorphan HBr 10 mg Phenylephrine HCl 5 mg"],"ask_doctor":["Ask a doctor before use if you have - Nighttime • liver disease • trouble urinating due to an enlarged prostate gland • cough that occurs with too much phlegm (mucus) • persistent or chronic cough as occurs with smoking, asthma, or emphysema • a breathing problem such as emphysema or chronic bronchitis • glaucoma • a sodium-restricted diet","Ask a doctor before use if you have - Daytime • liver disease • heart disease • thyroid disease • diabetes • high blood pressure • trouble urinating due to an enlarged prostate gland • cough that occurs with too much phlegm (mucus) • persistent or chronic cough as occurs with smoking, asthma, or emphysema"],"ask_doctor_or_pharmacist":["Ask a doctor or pharmacist before use if you are - Nighttime • taking sedatives or tranquilizers • taking the blood thinning drug warfarin","Ask a doctor or pharmacist before use if you are - Daytime taking the blood thinning drug warfarin"],"do_not_use":["Do not use - Nighttime • with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. • if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. • to make a child sleepy • if you have ever had an allergic reaction to this product or any of its ingredients","Do not use - Daytime • with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. • if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. • if you have ever had an allergic reaction to this product or any of its ingredients"],"dosage_and_administration":["Directions - Nighttime • take only as directed – see Liver warning • use dose cup • do not exceed 4 doses per 24 hrs adults & children 12 yrs & over 30 mL (2 TBSP) every 6 hrs children 4 to under 12 yrs ask a doctor children under 4 yrs do not use • when using other Daytime or Nighttime products, carefully read each label to insure correct dosing"],"dosage_and_administration_table":["
adults & children 12 yrs & over
30 mL (2 TBSP) every 6 hrs
children 4 to under 12 yrs
ask a doctor
children under 4 yrs
do not use
"],"effective_time":"20241215","id":"dd3afae7-8d6d-4dc8-a3dc-e460b56d9948","inactive_ingredient":["Inactive ingredients - Nighttime alcohol, anhydrous citric acid, FD&C blue no. 1, FD&C red no. 40, flavor, high fructose corn syrup, polyethylene glycol, propylene glycol, purified water, saccharin sodium, sodium citrate","Inactive Ingredients - Daytime butylated hydroxyanisole, edetate disodium, FD&C yellow no. 6, flavor, glycerin, menthol, monobasic sodium phosphate, polyethylene glycol, propylene glycol, purified water, saccharin sodium, sucrose, xanthan gum"],"indications_and_usage":["Uses - Nighttime temporarily relieves common cold/flu symptoms: • cough due to minor throat and bronchial irritation • sore throat • headache • minor aches and pains • fever • runny nose and sneezing","Uses - Daytime temporarily relieves common cold/flu symptoms: • nasal congestion • cough due to minor throat and bronchial irritation • sore throat • headache • minor aches and pains • fever"],"keep_out_of_reach_of_children":["Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222) Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms."],"openfda":{},"package_label_principal_display_panel":["Principal Display Panel - Daytime Compare to active ingredients in Vicks® DayQuil® Cold & Flu cold/flu relief multi-symptom day / non-drowsy pain reliever/fever reducer, cough suppressant, nasal decongestant acetaminophen – aches/fever dextromethorphan HBr – cough phenylephrine HCl – nasal congestion alcohol free, antihistamine free DAY original flavor","Principal Display Panel - Nighttime Compare to active ingredients in Vicks® NyQuil® Cold & Flu cold/flu relief multi-symptom night antihistamine, cough suppressant, fever reducer/pain reliever acetaminophen – aches/fever/sore throat dextromethorphan HBr – cough doxylamine succinate – sneezing, runny nose does not contain pseudoephedrine ALCOHOL 10% NIGHT cherry flavor TWO – 12 FL OZ (355 mL), TOTAL 24 FL OZ (1.5 pt) (710 mL) Up and Up Cold/Flu Relief Day Night Image 1 Up & Up Cold/Flu Relief Day Night Image 2 Up & Up Cold/Flu Relief Day Night Image 3"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding, ask a health professional before use."],"purpose":["Purpose - Nighttime Pain reliever/fever reducer Cough suppressant Antihistamine","Purpose - Daytime Pain reliever/fever reducer Cough suppressant Nasal decongestant"],"questions":["Questions? Call 1-800-910-6874"],"set_id":"0d8a9f95-982e-4a00-9dc0-49147da27276","spl_product_data_elements":["Up and Up Cold Flu Relief Day Night Acetaminophen, Dextromethorphan HBr, Doxylamine succinate, Phenylephrine HCl Up and Up Cold and Flu Relief acetaminophen, dextromethorphan hbr, doxylamine succinate ACETAMINOPHEN ACETAMINOPHEN DEXTROMETHORPHAN HYDROBROMIDE DEXTROMETHORPHAN DOXYLAMINE SUCCINATE DOXYLAMINE ALCOHOL ANHYDROUS CITRIC ACID FD&C BLUE NO. 1 FD&C RED NO. 40 HIGH FRUCTOSE CORN SYRUP POLYETHYLENE GLYCOL, UNSPECIFIED PROPYLENE GLYCOL WATER SACCHARIN SODIUM SODIUM CITRATE, UNSPECIFIED FORM Clear/Dark Red Menthol Aroma Up and Up Cold Flu Relief acetaminophen, dextromethorphan hbr, phenylephrine hcl ACETAMINOPHEN ACETAMINOPHEN DEXTROMETHORPHAN HYDROBROMIDE DEXTROMETHORPHAN PHENYLEPHRINE HYDROCHLORIDE PHENYLEPHRINE BUTYLATED HYDROXYANISOLE EDETATE DISODIUM FD&C YELLOW NO. 6 GLYCERIN SODIUM PHOSPHATE, MONOBASIC, ANHYDROUS POLYETHYLENE GLYCOL, UNSPECIFIED PROPYLENE GLYCOL WATER SACCHARIN SODIUM SUCROSE XANTHAN GUM MENTHOL, UNSPECIFIED FORM clear with fruit"],"spl_unclassified_section":["Warnings - Nighttime Liver warning: This product contains acetaminophen. The maximum daily dose of this product is 4 doses (2,600 mg acetaminophen) in 24 hours. Severe liver damage may occur if you take • more than 4,000 mg of acetaminophen in 24 hours • with other drugs containing acetaminophen • 3 or more alcoholic drinks every day while using this product Sore throat warning: If sore throat is severe, lasts for more than 2 days, occurs with or is followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.","Directions - Daytime • take only as directed – see Liver warning • use dose cup • do not exceed 4 doses per 24 hrs adults & children 12 yrs & over 30 mL (2 TBSP) every 4 hrs children 6 to under 12 yrs 15 mL (1 TBSP) every 4 hrs children 4 to under 6 yrs ask a doctor children under 4 yrs do not use • when using other Daytime or Nighttime products, carefully read each label to insure correct dosing"],"spl_unclassified_section_table":["
adults & children 12 yrs & over
30 mL (2 TBSP) every 4 hrs
children 6 to under 12 yrs
15 mL (1 TBSP) every 4 hrs
children 4 to under 6 yrs
ask a doctor
children under 4 yrs
do not use
"],"stop_use":["Stop use and ask a doctor if - Nighttime • pain or cough gets worse or lasts more than 7 days • fever gets worse or lasts more than 3 days • redness or swelling is present • new symptoms occur • cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition.","Stop use and ask a doctor if - Daytime • you get nervous, dizzy or sleepless • pain, nasal congestion or cough gets worse or lasts more than 5 days (children) or 7 days (adults) • fever gets worse or lasts more than 3 days • redness or swelling is present • new symptoms occur • cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition"],"storage_and_handling":["Other information - Nighttime • each 30 mL dose cup contains: sodium 39 mg • store at 20-25°C (68-77°F)","Other information - Daytime • each tablespoon contains: sodium 7 mg • store at 20-25°C (68-77°F)"],"version":"4","warnings":["Warnings - Daytime Liver warning: This product contains acetaminophen. The maximum daily dose of this product is 4 doses (adult: 2,600 mg acetaminophen; child: 1,300 mg acetaminophen) in 24 hours. Severe liver damage may occur if • adult takes more than 4,000 mg of acetaminophen in 24 hours • child takes more than 5 doses in 24 hours, which is the maximum daily amount • taken with other drugs containing acetaminophen • adult has 3 or more alcoholic drinks every day while using this product Sore throat warning: If sore throat is severe, lasts for more than 2 days, occurs with or is followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly. Do not use - Nighttime • with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. • if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. • to make a child sleepy • if you have ever had an allergic reaction to this product or any of its ingredients Do not use - Daytime • with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. • if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. • if you have ever had an allergic reaction to this product or any of its ingredients Ask a doctor before use if you have - Nighttime • liver disease • trouble urinating due to an enlarged prostate gland • cough that occurs with too much phlegm (mucus) • persistent or chronic cough as occurs with smoking, asthma, or emphysema • a breathing problem such as emphysema or chronic bronchitis • glaucoma • a sodium-restricted diet Ask a doctor before use if you have - Daytime • liver disease • heart disease • thyroid disease • diabetes • high blood pressure • trouble urinating due to an enlarged prostate gland • cough that occurs with too much phlegm (mucus) • persistent or chronic cough as occurs with smoking, asthma, or emphysema Ask a doctor or pharmacist before use if you are - Nighttime • taking sedatives or tranquilizers • taking the blood thinning drug warfarin Ask a doctor or pharmacist before use if you are - Daytime taking the blood thinning drug warfarin When using this product - Nighttime • excitability may occur, especially in children • marked drowsiness may occur • avoid alcoholic drinks • be careful when driving a motor vehicle or operating machinery • alcohol, sedatives, and tranquilizers may increase drowsiness When using this product - Daytime do not use more than directed Stop use and ask a doctor if - Nighttime • pain or cough gets worse or lasts more than 7 days • fever gets worse or lasts more than 3 days • redness or swelling is present • new symptoms occur • cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition. Stop use and ask a doctor if - Daytime • you get nervous, dizzy or sleepless • pain, nasal congestion or cough gets worse or lasts more than 5 days (children) or 7 days (adults) • fever gets worse or lasts more than 3 days • redness or swelling is present • new symptoms occur • cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222) Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms."],"when_using":["When using this product - Nighttime • excitability may occur, especially in children • marked drowsiness may occur • avoid alcoholic drinks • be careful when driving a motor vehicle or operating machinery • alcohol, sedatives, and tranquilizers may increase drowsiness","When using this product - Daytime do not use more than directed"]}