{"active_ingredient":["Active ingredients Carboxymethylcellulose sodium 0.5% Glycerin 1% Polysorbate 80 0.5%"],"dosage_and_administration":["Directions Prior to first use, please read the “Instructions for Use” inside this carton. Instill 1 or 2 drops in the affected eye(s) as needed."],"effective_time":"20260301","id":"f1b7ee33-3765-45ca-8cf5-86422e001757","inactive_ingredient":["Inactive ingredients Boric acid; butylated hydroxyl toluene; carbomer copolymer type A; castor oil; erythritol; flaxseed oil; levocarnitine; polyoxyl 40 stearate; purified water; and trehalose. May contain hydrochloric acid and/or sodium hydroxide (to adjust pH)."],"indications_and_usage":["Uses For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun. May be used as a protectant against further irritation."],"keep_out_of_reach_of_children":["Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"openfda":{"application_number":["M018"],"brand_name":["Refresh Optive Mega-3 PF"],"generic_name":["CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80"],"is_original_packager":[true],"manufacturer_name":["Allergan, Inc."],"nui":["N0000185370","N0000175629","N0000184306","N0000185001","M0000728","M0009417"],"package_ndc":["0023-3988-10","0023-3988-05"],"pharm_class_cs":["Allergens [CS]","Glycerol [CS]"],"pharm_class_epc":["Non-Standardized Chemical Allergen [EPC]"],"pharm_class_pe":["Increased Histamine Release [PE]","Cell-mediated Immunity [PE]","Increased IgG Production [PE]"],"product_ndc":["0023-3988"],"product_type":["HUMAN OTC DRUG"],"route":["OPHTHALMIC"],"rxcui":["1241471"],"spl_id":["f1b7ee33-3765-45ca-8cf5-86422e001757"],"spl_set_id":["326cb5d6-c784-404f-9a13-6d69262dda6e"],"substance_name":["CARBOXYMETHYLCELLULOSE SODIUM","GLYCERIN","POLYSORBATE 80"],"unii":["K679OBS311","PDC6A3C0OX","6OZP39ZG8H"]},"other_safety_information":["Other information Use only if tape seals on top and bottom flaps are intact. Use before expiration date marked on container. Discard 90 days after opening. Store at 59°-77°F (15°-25°C). RETAIN THIS CARTON AND THE INSERT FOR FUTURE REFERENCE"],"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL NDC 0023-3988-10 PRESERVATIVE-FREE Refresh OPTIVE MEGA-3 ® PF Lubricant Eye Drops w ith Hydro C ell ® Fast-Acting Dry Eye Relief . Formula Enhanced With Flaxseed Oil * . 0.33 fl oz (10 mL) Sterile NDC 0023-3988-10 PRESERVATIVE-FREE Refresh OPTIVE MEGA-3® PF Lubricant Eye Drops with HydroCell® Fast-Acting Dry Eye Relief. Formula Enhanced With Flaxseed Oil*. 0.33 fl oz (10 mL) Sterile"],"purpose":["Purpose Eye lubricant Eye lubricant Eye lubricant"],"questions":["Questions or comments? 1.800.678.160 5 r efresheyedrops.com V1.0DFL3988"],"set_id":"326cb5d6-c784-404f-9a13-6d69262dda6e","spl_product_data_elements":["Refresh Optive Mega-3 PF carboxymethylcellulose sodium, Glycerin, Polysorbate 80 CARBOXYMETHYLCELLULOSE SODIUM CARBOXYMETHYLCELLULOSE GLYCERIN GLYCERIN POLYSORBATE 80 POLYSORBATE 80 BORIC ACID BUTYLATED HYDROXYTOLUENE CARBOMER COPOLYMER TYPE A (ALLYL PENTAERYTHRITOL CROSSLINKED) CASTOR OIL ERYTHRITOL LINSEED OIL LEVOCARNITINE POLYOXYL STEARATE 40 WATER TREHALOSE HYDROCHLORIC ACID SODIUM HYDROXIDE"],"stop_use":["Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours."],"version":"6","warnings":["Warnings For external use only. To avoid contamination, do not touch tip of container to any surface. Replace cap after using. If solution changes color, do not use. Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."]}