EPICEL

MAUDE Adverse Event Report

MAUDE data represents reports of adverse events involving medical devices. This maude entry was filed from a 04 report with the FDA on 2013-12-18 for EPICEL manufactured by Genzyme Biosurgery (cambridge).

Event Text Entries

[16449884] This unsolicited device case from united states was received on (b)(4) 2013 form a non-healthcare professional. This case concerns a (b)(6) male pt who expired after grafting with epicel cultured epidermal autografts (epicel). It was reported that the pt was not allergic to vancomycin, amikacin, amphotericin b. The pt's concomitant medications included silver nitrate solution for microbial wound infection. No medical history, past drugs or concurrent conditions were reported. On (b)(6) 2012, the pt sustained 99 percent of total body surface area (tbsa) thermal burns and the same day, he was hospitalized. The pt had wound infection and wound culture performed on (b)(6) 2012 grew gram negative rods (gnr, 2+). On (b)(6) 2012 (at 15:00 pm), biopsies were performed at right anterior thigh (tube number: 1 and 2). It was reported that the pt had no systemic microbial infection. On (b)(6) 2012 and (b)(6) 2013, respectively, the pt was grafted with 48 grafts of epicel cultured epidermal autografts (batch/lot number ee01646 for the grafts used on (b)(6) 2012 and expiration date: 11/30/2012) on an unspecified location for thermal burn. On (b)(6) 2013 (one month following third grafting with epicel cultured epidermal autografts), the pt died due to an unreported cause. Corrective treatment: unk. Outcome: fatal. A pharmaceutical technical complaint (ptc) was initiated with global ptc number (b)(4) and results were pending for the same. Additional information was received on (b)(4) 2013 in the form of a biopsy transmittal form. The pt's demographics (gender and age), details of thermal burns, biopsy details and concurrent medication of silver nitrate solution were added. The text was amended accordingly.
Patient Sequence No: 1, Text Type: D, B5


MAUDE Entry Details

Report Number1226230-2013-29912
MDR Report Key3624943
Report Source04
Date Received2013-12-18
Date of Report2013-12-10
Date of Event2013-02-27
Date Mfgr Received2013-12-10
Date Added to Maude2014-02-14
Event Key0
Report Source CodeManufacturer report
Manufacturer LinkY
Number of Patients in Event0
Adverse Event Flag3
Product Problem Flag3
Reprocessed and Reused Flag0
Health Professional3
Initial Report to FDA3
Report to FDA0
Event Location0
Manufacturer Street55 CORPORATE DRIVE 55D-205A
Manufacturer CityBRIDGEWATER NJ 08807
Manufacturer CountryUS
Manufacturer Postal08807
Manufacturer Phone9089816698
Single Use3
Previous Use Code3
Event Type3
Type of Report3

Device Details

Brand NameEPICEL
Generic NameCULTURED EPIDERMAL AUTOGRAFTS
Product CodeOCE
Date Received2013-12-18
Lot NumberEE01646
Device Expiration Date2012-11-30
OperatorOTHER
Device AgeDA
Device Eval'ed by Mfgr*
Device Sequence No1
Device Event Key0
ManufacturerGENZYME BIOSURGERY (CAMBRIDGE)
Manufacturer AddressCAMBRIDGE MA US


Patients

Patient NumberTreatmentOutcomeDate
101. Death 2013-12-18

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