MAUDE MDR 6215908

MDR report key
6215908
Report number
3002769706-2016-00531
Event key
0
Event type
3
Date received
2016-12-30
Adverse event
3
Product problem
3
Patients in event
0
Reporter occupation
0
Health professional
3
Initial report to FDA
3
Event location
3

Manufacturer Contact#

Contact
ELLEN WELTMER
Address
595 ANGLUM ROAD ST. LOUIS MO 63042 US
Report source
M
Manufacturer link flag
Y

Devices#

Seq, Brand, Generic table
SeqBrandGenericManufacturerProduct codeModelCatalogLotPMA510(k)ImplantEvaluatedAvailability
1NUCLISENS? MAGNETIC EXTRACTION REAGENTSNUCLISENS? MAGNETIC EXTRACTION REAGENTSBIOM?RIEUX SAJJH20029316072701R N

Patients#

Sequence, Received, Treatment table
SequenceReceivedTreatmentOutcome
12016-12-300

Event Narratives#

D

Patient 1

A CUSTOMER IN THE NETHERLANDS CONTACTED BIOM?RIEUX TO REPORT DISCREPANT RESULTS WITH NUCLISENS MAGNETIC EXTRACTION REAGENT PRODUCT INVOLVING A RECOVERY ISSUE WITH THE SILICA. THE CUSTOMER, AN INDUSTRY FOOD LABORATORY THAT FOLLOWS ISO 15216 FOR VIRUS DETECTION IN FOOD, USES A BIB PROCESS CONTROL OF A SIMILAR VIRUS THAT THEY WANT TO DETECT AND THIS SIMILAR VIRUS IS SPIKED (B)(6)SAMPLE. THE CUSTOMER REPORTED A DIFFERENCE WITH RESPECT TO THE INTERNAL QUALITY CONTROL BETWEEN THE RECALLED BATCH (IDENTIFIED AS "BAD BATCH")AND THE NEW BATCH (IDENTIFIED AS "GOOD BATCH) AS FOLLOWS: (B)(6). THE CUSTOMER INDICATED A SHIFT OF ABOUT (B)(6) BETWEEN THE GOOD AND BAD BATCHES. INDICATING THAT WITH A LOW AMOUNT OF VIRUS IN THEIR SAMPLE THEY COULD HAVE ENCOUNTERED (B)(6) RESULTS. THE CUSTOMER INDICATED THE TARGET VIRUS AS (B)(6) , EXTRACTION OF RNA FROM (B)(6) OF EACH FOOD SAMPLE USING AN APPROPRIATE GUANIDINE THIOCYANATE DISRUPTION AND SILICA ABSORPTION-BASED METHOD. THE INTERNAL CONTROL WAS INDICATED AS A PROCESS CONTROL VIRUS STOCK SIMILAR TO THE VIRUS TO DETECT. THE CUSTOMER CONFIRMED NOT RECEIVING FALSE RESULTS ONLY LOWER RECOVERY. THERE IS NO PATIENT INVOLVED IN THIS EVENT, BECAUSE THE CUSTOMER IS AN INDUSTRY (NON-CLINICAL CUSTOMER). THERE IS NO INDICATION OR REPORT FROM THE LABORATORY THAT THE DISCREPANT RESULT LED TO ANY ADVERSE EVENT. BIOM?RIEUX INVESTIGATION WILL BE INITIATED.

N

Patient 1

AN INTERNAL BIOM?RIEUX INVESTIGATION WAS CONDUCTED. RESULTS ARE AS FOLLOWS: A DIFFERENCE OF QUANTIFICATION UP TO 1 LOG AND SOMETIMES MORE THAN 1 LOG WAS OBSERVED. AS THE DOWNSTREAM APPLICATIONS ARE QUALITATIVE AND/OR QUANTITATIVE, THE DECREASE OF PERFORMANCES IN DOWNSTREAM APPLICATION COULD LEAD TO: A RISK OF FALSE NEGATIVE FOR QUALITATIVE TESTS, INVALID RESULTS WHEN EXTRACTED AND AMPLIFIED INTERNAL CONTROL IS NOT WITHIN SPECIFICATIONS, UNDER-QUANTIFICATION FOR VIRAL LOAD RESULTS FOR QUANTITATIVE TESTS WE HAVE CONFIRMED THE ISSUE FOR THE FOLLOWING CUSTOMER'S APPLICATION SPECIFICITY: IMPACT WHEN USING A HIGH SAMPLE INPUT VOLUME, FROM 200 L AND UP TO 1 ML. IMPACT WHEN DOUBLE STRANDED NUCLEIC ACID APPLICATIONS WITH SMALL (