Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate

Product NDC
0591-3220
Requested package NDC
0591-3220-01
11-digit product format
005913220
Labeler code
0591
Product ID
0591-3220_519e2ce9-e4af-4bd7-96fd-8bee4e3b4537
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate
Dosage form
CAPSULE
Route
ORAL
Labeler
Actavis Pharma, Inc.
Application
NDA020232
Marketing category
NDA AUTHORIZED GENERIC
Marketing start
2003-09-18
Substance
ACETAMINOPHEN; BUTALBITAL; CAFFEINE; CODEINE PHOSPHATE
Active strength
325; 50; 40; 30 mg/1; mg/1; mg/1; mg/1
Pharmacologic classes
Barbiturate [EPC], Barbiturates [CS], Central Nervous System Stimulant [EPC], Central Nervous System Stimulation [PE], Full Opioid Agonists [MoA], Methylxanthine [EPC], Opioid Agonist [EPC], Xanthines [CS]
DEA schedule
CIII
NDC exclude flag
No
Listing certified through
2027-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N020232-001FIORICET W/ CODEINEACETAMINOPHEN; BUTALBITAL; CAFFEINE; CODEINE PHOSPHATE325MG;50MG;40MG;30MGCAPSULE / ORALABRLD, RS1992-07-30

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
N020232-001AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-01 22:54:322026-06N020232-001FIORICET W/ CODEINE325MG;50MG;40MG;30MGCAPSULE / ORALABRLD, RS1992-07-30a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-01 22:54:322026-06N020232-001AB1a50c72e98297…

openFDA label cross-check#

Cross-check layer: openFDA label JSON enriches search and identifies hydration gaps. The DailyMed Structured Product Label remains the canonical label presentation on FDA.report. Every label matching the complete exact-identifier union is deduplicated and paginated below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Butalbital, Acetaminophen, Caffeine, and Codeine PhosphateBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATEActavis Pharma, Inc.a58819b8-a52c-44a7-9ab0-c74480d985062026-01-09Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (NDA): 020232
application number: NDA020232
ndc (package): 0591-3220-01
ndc (product): 0591-3220
ndc11 (package): 00591322001

Additional Listing Data#

Finished product
Yes
Brand name base
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate
Listing expiration
2027-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
CODEINE PHOSPHATE325 mg/1
BUTALBITAL50 mg/1
CAFFEINE40 mg/1
ACETAMINOPHEN30 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 4 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
GSL05Y1MN6Internal UNII lookup
KHS0AZ4JVKInternal UNII lookup
3G6A5W338EInternal UNII lookup
362O9ITL9DInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
993943Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
a58819b8-a52c-44a7-9ab0-c74480d98506Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
7dea7767-9f52-b60a-5435-33cb9cc28baeProduct name420250124
6338270f-96cb-0ecb-6fbb-0a9bc78001f4Product name720250116
11939cf5-0ea7-5df5-5127-00a7ce07fd7fProduct name520250115
0ca83774-3f79-b837-5d6f-c210102f3bc8Product name620250114
88300afc-e1c4-ad17-c80b-4957f1b809a5Product name520250113
79e1734e-f721-4d46-978a-be382f771672Product name220230110
41b814f3-0166-1c53-c9ef-a0794c7daf9dProduct name320221110
a590be26-846c-8659-a5a1-fb25907965dcProduct name220221110
09d8330d-4fec-be98-3a66-f985140646b2Product name220210513
2dc76302-91c0-4c35-ad78-99adfb049c4bProduct name120200603
103b151b-b17f-42ac-8624-3ef62f5e2975Product name220200507
20c8cafe-5cfc-44f8-a9be-a664f437f780Product name220200225
e6065d4b-5ae1-476f-a40e-f2851cbb5d2bProduct name220180221
f212291f-05fe-9603-fc7e-bd73e38ce1e6Product name220161129
182f9ab4-4ab5-c449-200f-87ce2ce8e550Product name220151105
e0b6c8be-f2bd-9f86-a9fc-3ed56ffaa814Product name320150910
c6fba691-a132-4ede-95c6-f8c6bd696636Product name120150902
c0200ab5-4954-454e-9676-30b741b245bdProduct name120150730
e9576821-a971-5261-628e-82ad9e10acdbProduct name220150121
2a21311a-89e2-0e83-2ebd-117f9798b2b2Product name120140508
30c51294-7ae9-8007-7de6-58222684a0beProduct name120140508
332e86c3-7875-ca6e-f934-2206d2b31996Product name120140508
3ed6b849-48b8-8899-c288-6eeb396123b6Product name120140508
47fd879b-91c5-e1e5-130f-29d082a871ecProduct name120140508
56625fcc-aa34-9d30-d0e9-1c1beb37ea21Product name120140508
7dfac40f-a405-cd2e-7c06-3059ec0e1092Product name120140508
96c2be53-8e44-452d-56a2-d255b2f1af2dProduct name120140508
bf8bd5f7-495f-4022-2780-7ded7ea7ea44Product name120140508
c35d1ac8-8885-2ee1-6c52-5a715b242c00Product name120140508
ce055423-1d7f-3c41-dff1-83660fa8cd96Product name120140508
d223c173-c39b-d764-47d4-d671d3088815Product name120140508
e01133ad-4dcd-c7f3-454b-2ff569ee160aProduct name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
0591-3220-01Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate100 in 1 BOTTLECAPSULE10038

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
0591-3220-01EA - Each0591-3220e95c8235-3333-4913-bee6-d8ec4dbdca5f12012-07-24

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
IngredientTypeUNIIDailyMed labelSPL versionUploaded
ACETAMINOPHENACTIVE INGREDIENT362O9ITL9DBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [ACTAVIS PHARMA, INC.]21
BUTALBITALACTIVE INGREDIENTKHS0AZ4JVKBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [ACTAVIS PHARMA, INC.]21
CAFFEINEACTIVE INGREDIENT3G6A5W338EBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [ACTAVIS PHARMA, INC.]21
CODEINE PHOSPHATEACTIVE INGREDIENTGSL05Y1MN6BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [ACTAVIS PHARMA, INC.]21
ACETAMINOPHENACTIVE MOIETY362O9ITL9DBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [ACTAVIS PHARMA, INC.]21
BUTALBITALACTIVE MOIETYKHS0AZ4JVKBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [ACTAVIS PHARMA, INC.]21
CAFFEINEACTIVE MOIETY3G6A5W338EBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [ACTAVIS PHARMA, INC.]21
CODEINE ANHYDROUSACTIVE MOIETYUX6OWY2V7JBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [ACTAVIS PHARMA, INC.]21
D&C RED NO. 33INACTIVE INGREDIENT9DBA0SBB0LBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [ACTAVIS PHARMA, INC.]21
D&C RED NO. 7INACTIVE INGREDIENTECW0LZ41X8BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [ACTAVIS PHARMA, INC.]21
FD&C BLUE NO. 1INACTIVE INGREDIENTH3R47K3TBDBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [ACTAVIS PHARMA, INC.]21
GELATININACTIVE INGREDIENT2G86QN327LBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [ACTAVIS PHARMA, INC.]21
MAGNESIUM STEARATEINACTIVE INGREDIENT70097M6I30BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [ACTAVIS PHARMA, INC.]21
SILICON DIOXIDEINACTIVE INGREDIENTETJ7Z6XBU4BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [ACTAVIS PHARMA, INC.]21
STARCH, CORNINACTIVE INGREDIENTO8232NY3SJBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [ACTAVIS PHARMA, INC.]21
TITANIUM DIOXIDEINACTIVE INGREDIENT15FIX9V2JPBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [ACTAVIS PHARMA, INC.]21
ACETAMINOPHENACTIVE INGREDIENT362O9ITL9DBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (CODEINE PHOSPHATE, BUTALBITAL, CAFFEINE, AND ACETAMINOPHEN CAPSULE) CAPSULE [PHYSICIANS TOTAL CARE, INC.]3
BUTALBITALACTIVE INGREDIENTKHS0AZ4JVKBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (CODEINE PHOSPHATE, BUTALBITAL, CAFFEINE, AND ACETAMINOPHEN CAPSULE) CAPSULE [PHYSICIANS TOTAL CARE, INC.]3
CAFFEINEACTIVE INGREDIENT3G6A5W338EBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (CODEINE PHOSPHATE, BUTALBITAL, CAFFEINE, AND ACETAMINOPHEN CAPSULE) CAPSULE [PHYSICIANS TOTAL CARE, INC.]3
CODEINE PHOSPHATEACTIVE INGREDIENTGSL05Y1MN6BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (CODEINE PHOSPHATE, BUTALBITAL, CAFFEINE, AND ACETAMINOPHEN CAPSULE) CAPSULE [PHYSICIANS TOTAL CARE, INC.]3
ACETAMINOPHENACTIVE MOIETY362O9ITL9DBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (CODEINE PHOSPHATE, BUTALBITAL, CAFFEINE, AND ACETAMINOPHEN CAPSULE) CAPSULE [PHYSICIANS TOTAL CARE, INC.]3
BUTALBITALACTIVE MOIETYKHS0AZ4JVKBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (CODEINE PHOSPHATE, BUTALBITAL, CAFFEINE, AND ACETAMINOPHEN CAPSULE) CAPSULE [PHYSICIANS TOTAL CARE, INC.]3
CAFFEINEACTIVE MOIETY3G6A5W338EBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (CODEINE PHOSPHATE, BUTALBITAL, CAFFEINE, AND ACETAMINOPHEN CAPSULE) CAPSULE [PHYSICIANS TOTAL CARE, INC.]3
CODEINEACTIVE MOIETYQ830PW7520BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (CODEINE PHOSPHATE, BUTALBITAL, CAFFEINE, AND ACETAMINOPHEN CAPSULE) CAPSULE [PHYSICIANS TOTAL CARE, INC.]3
D&C RED NO. 33INACTIVE INGREDIENT9DBA0SBB0LBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (CODEINE PHOSPHATE, BUTALBITAL, CAFFEINE, AND ACETAMINOPHEN CAPSULE) CAPSULE [PHYSICIANS TOTAL CARE, INC.]3
D&C RED NO. 7INACTIVE INGREDIENTECW0LZ41X8BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (CODEINE PHOSPHATE, BUTALBITAL, CAFFEINE, AND ACETAMINOPHEN CAPSULE) CAPSULE [PHYSICIANS TOTAL CARE, INC.]3
FD&C BLUE NO. 1INACTIVE INGREDIENTH3R47K3TBDBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (CODEINE PHOSPHATE, BUTALBITAL, CAFFEINE, AND ACETAMINOPHEN CAPSULE) CAPSULE [PHYSICIANS TOTAL CARE, INC.]3
GELATININACTIVE INGREDIENT2G86QN327LBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (CODEINE PHOSPHATE, BUTALBITAL, CAFFEINE, AND ACETAMINOPHEN CAPSULE) CAPSULE [PHYSICIANS TOTAL CARE, INC.]3
MAGNESIUM STEARATEINACTIVE INGREDIENT70097M6I30BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (CODEINE PHOSPHATE, BUTALBITAL, CAFFEINE, AND ACETAMINOPHEN CAPSULE) CAPSULE [PHYSICIANS TOTAL CARE, INC.]3
SILICON DIOXIDEINACTIVE INGREDIENTETJ7Z6XBU4BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (CODEINE PHOSPHATE, BUTALBITAL, CAFFEINE, AND ACETAMINOPHEN CAPSULE) CAPSULE [PHYSICIANS TOTAL CARE, INC.]3
STARCH, CORNINACTIVE INGREDIENTO8232NY3SJBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (CODEINE PHOSPHATE, BUTALBITAL, CAFFEINE, AND ACETAMINOPHEN CAPSULE) CAPSULE [PHYSICIANS TOTAL CARE, INC.]3
TITANIUM DIOXIDEINACTIVE INGREDIENT15FIX9V2JPBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE (CODEINE PHOSPHATE, BUTALBITAL, CAFFEINE, AND ACETAMINOPHEN CAPSULE) CAPSULE [PHYSICIANS TOTAL CARE, INC.]3
ACETAMINOPHENACTIVE INGREDIENT362O9ITL9DBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [BRYANT RANCH PREPACK]2
BUTALBITALACTIVE INGREDIENTKHS0AZ4JVKBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [BRYANT RANCH PREPACK]2
CAFFEINEACTIVE INGREDIENT3G6A5W338EBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [BRYANT RANCH PREPACK]2
CODEINE PHOSPHATEACTIVE INGREDIENTGSL05Y1MN6BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [BRYANT RANCH PREPACK]2
ACETAMINOPHENACTIVE MOIETY362O9ITL9DBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [BRYANT RANCH PREPACK]2
BUTALBITALACTIVE MOIETYKHS0AZ4JVKBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [BRYANT RANCH PREPACK]2
CAFFEINEACTIVE MOIETY3G6A5W338EBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [BRYANT RANCH PREPACK]2
CODEINE ANHYDROUSACTIVE MOIETYUX6OWY2V7JBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [BRYANT RANCH PREPACK]2
D&C RED NO. 33INACTIVE INGREDIENT9DBA0SBB0LBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [BRYANT RANCH PREPACK]2
D&C RED NO. 7INACTIVE INGREDIENTECW0LZ41X8BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [BRYANT RANCH PREPACK]2
FD&C BLUE NO. 1INACTIVE INGREDIENTH3R47K3TBDBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [BRYANT RANCH PREPACK]2
GELATININACTIVE INGREDIENT2G86QN327LBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [BRYANT RANCH PREPACK]2
MAGNESIUM STEARATEINACTIVE INGREDIENT70097M6I30BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [BRYANT RANCH PREPACK]2
SILICON DIOXIDEINACTIVE INGREDIENTETJ7Z6XBU4BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [BRYANT RANCH PREPACK]2
STARCH, CORNINACTIVE INGREDIENTO8232NY3SJBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [BRYANT RANCH PREPACK]2
TITANIUM DIOXIDEINACTIVE INGREDIENT15FIX9V2JPBUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [BRYANT RANCH PREPACK]2

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
0591-3220BUTALBITAL, ACETAMINOPHEN, CAFFEINE, AND CODEINE PHOSPHATE CAPSULE [ACTAVIS PHARMA, INC.]33Current NDC, Legacy NDC, 1 package rows20240412_a58819b8-a52c-44a7-9ab0-c74480d98506.zip

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
993943butalbital 50 MG / acetaminophen 325 MG / caffeine 40 MG / codeine phosphate 30 MG Oral CapsulePSNa58819b8-a52c-44a7-9ab0-c74480d9850638
993943acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG / codeine phosphate 30 MG Oral CapsuleSCDa58819b8-a52c-44a7-9ab0-c74480d9850638
993943APAP 325 MG / butalbital 50 MG / caffeine 40 MG / codeine phosphate 30 MG Oral CapsuleSYa58819b8-a52c-44a7-9ab0-c74480d9850638
993943butalbital 50 MG / acetaminophen 325 MG / caffeine 40 MG / codeine phosphate 30 MG Oral CapsulePSN908bdfc3-ac28-44c9-aa59-39e7b9b289033
993943acetaminophen 325 MG / butalbital 50 MG / caffeine 40 MG / codeine phosphate 30 MG Oral CapsuleSCD908bdfc3-ac28-44c9-aa59-39e7b9b289033
993943APAP 325 MG / butalbital 50 MG / caffeine 40 MG / codeine phosphate 30 MG Oral CapsuleSY908bdfc3-ac28-44c9-aa59-39e7b9b289033

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
0591-3220-0100591322001100 CAPSULE in 1 BOTTLE (0591-3220-01) 100 capsule2003-09-180000-00-00NoNoCurrent