BAYER HLTHCARE FDA Approval NDA 203085

NDA 203085

BAYER HLTHCARE

FDA Drug Application

Application #203085

Documents

Letter2015-04-16
Letter2016-06-08
Label2012-09-27
Label2013-06-04
Summary Review2012-10-26
Letter2012-09-27
Letter2013-05-31
Label2015-04-14
Review2012-10-26
Letter2016-08-26
Label2016-08-26
Label2017-04-27
Letter2017-05-02
Letter2018-06-20
Label2018-06-21
Letter2019-08-01
Label2019-08-02
Review2019-08-07
Label2020-02-14
Letter2020-02-14
Label2020-07-22
Letter2020-07-22
Letter2020-09-25
Label2020-12-23
Letter2020-12-23

Application Sponsors

NDA 203085BAYER HLTHCARE

Marketing Status

Prescription001

Application Products

001TABLET;ORAL40MG1STIVARGAREGORAFENIB

FDA Submissions

TYPE 1; Type 1 - New Molecular EntityORIG1AP2012-09-27PRIORITY
MANUF (CMC); Manufacturing (CMC)SUPPL2AP2014-11-10PRIORITY
MANUF (CMC); Manufacturing (CMC)SUPPL3AP2013-09-13PRIORITY
LABELING; LabelingSUPPL4AP2015-04-13STANDARD
LABELING; LabelingSUPPL5AP2016-06-07STANDARD
LABELING; LabelingSUPPL6AP2016-08-26STANDARD
EFFICACY; EfficacySUPPL7AP2017-04-27PRIORITY
EFFICACY; EfficacySUPPL8AP2018-06-14STANDARD
LABELING; LabelingSUPPL10AP2019-07-31STANDARD
LABELING; LabelingSUPPL11AP2020-02-13STANDARD
LABELING; LabelingSUPPL12AP2020-09-24STANDARD
LABELING; LabelingSUPPL13AP2020-07-21STANDARD
MANUF (CMC); Manufacturing (CMC)SUPPL14AP2020-12-10STANDARD

Submissions Property Types

ORIG1Null7
SUPPL2Null0
SUPPL3Null0
SUPPL4Null15
SUPPL5Null6
SUPPL6Null6
SUPPL7Null7
SUPPL8Orphan5
SUPPL10Null7
SUPPL11Null7
SUPPL12Orphan5
SUPPL13Null7

CDER Filings

BAYER HLTHCARE
cder:Array
(
    [0] => Array
        (
            [ApplNo] => 203085
            [companyName] => BAYER HLTHCARE
            [docInserts] => ["",""]
            [products] => [{"drugName":"STIVARGA","activeIngredients":"REGORAFENIB","strength":"40MG","dosageForm":"TABLET;ORAL","marketingStatus":"Prescription","te":"None","rld":"Yes","rs":"Yes"}]
            [labels] => [{"actionDate":"12\/10\/2020","submission":"SUPPL-14","supplementCategories":"Manufacturing (CMC)","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2020\\\/203085Orig1s014lbl.pdf\"}]","notes":"This supplement type does not usually require new labeling."},{"actionDate":"07\/21\/2020","submission":"SUPPL-13","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2020\\\/203085s013lbl.pdf\"}]","notes":""},{"actionDate":"02\/13\/2020","submission":"SUPPL-11","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2020\\\/203085s011lbl.pdf\"}]","notes":""},{"actionDate":"07\/31\/2019","submission":"SUPPL-10","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2019\\\/203085s010lbl.pdf\"}]","notes":""},{"actionDate":"06\/14\/2018","submission":"SUPPL-8","supplementCategories":"Efficacy-Labeling Change With Clinical Data","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2018\\\/203085s008lbl.pdf\"}]","notes":""},{"actionDate":"04\/27\/2017","submission":"SUPPL-7","supplementCategories":"Efficacy-New Indication","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2017\\\/203085s007lbl.pdf\"}]","notes":""},{"actionDate":"08\/26\/2016","submission":"SUPPL-6","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2016\\\/203085s006lbl.pdf\"}]","notes":""},{"actionDate":"04\/13\/2015","submission":"SUPPL-4","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2015\\\/203085s004lbl.pdf\"}]","notes":""},{"actionDate":"05\/29\/2013","submission":"SUPPL-1","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2013\\\/203085s001lbl.pdf\"}]","notes":""},{"actionDate":"09\/27\/2012","submission":"ORIG-1","supplementCategories":"Approval","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2012\\\/203085lbl.pdf\"}]","notes":""}]
            [originalApprovals] => [{"actionDate":"09\/27\/2012","submission":"ORIG-1","actionType":"Approval","submissionClassification":"Type 1 - New Molecular Entity","reviewPriority":"PRIORITY; Orphan","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2012\\\/203085lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2012\\\/203085Orig1s000ltr.pdf\"},{\"name\":\"Review\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/nda\\\/2012\\\/203085Orig1s000TOC.cfm\"},{\"name\":\"Summary Review (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/nda\\\/2012\\\/203085Orig1s000SumR.pdf\"}]","notes":">"}]
            [supplements] => [{"actionDate":"12\/10\/2020","submission":"SUPPL-14","supplementCategories":"Manufacturing (CMC)","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2020\\\/203085Orig1s014lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2021\\\/203085Orig1s014ltr.pdf\"}]","notes":">"},{"actionDate":"07\/21\/2020","submission":"SUPPL-13","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2020\\\/203085s013lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2020\\\/203085Orig1s013ltr.pdf\"}]","notes":">"},{"actionDate":"09\/24\/2020","submission":"SUPPL-12","supplementCategories":"Labeling-Container\/Carton Labels","inserts":"[{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2020\\\/203085Orig1s012ltr.pdf\"}]","notes":"> Label is not available on this site."},{"actionDate":"02\/13\/2020","submission":"SUPPL-11","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2020\\\/203085s011lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2020\\\/203085Orig1s011ltr.pdf\"}]","notes":">"},{"actionDate":"07\/31\/2019","submission":"SUPPL-10","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2019\\\/203085s010lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2019\\\/203085Orig1s010ltr.pdf\"}]","notes":">"},{"actionDate":"06\/14\/2018","submission":"SUPPL-8","supplementCategories":"Efficacy-Labeling Change With Clinical Data","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2018\\\/203085s008lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2018\\\/203085Orig1s008ltr.pdf\"}]","notes":">"},{"actionDate":"04\/27\/2017","submission":"SUPPL-7","supplementCategories":"Efficacy-New Indication","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2017\\\/203085s007lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2017\\\/203085Orig1s007.pdf\"},{\"name\":\"Review (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/nda\\\/2019\\\/203085Orig1s007.pdf\"}]","notes":">"},{"actionDate":"08\/26\/2016","submission":"SUPPL-6","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2016\\\/203085s006lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2016\\\/203085Orig1s006ltr.pdf\"}]","notes":">"},{"actionDate":"06\/07\/2016","submission":"SUPPL-5","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2016\\\/203085Orig1s005ltr.pdf\"}]","notes":"> Label is not available on this site."},{"actionDate":"04\/13\/2015","submission":"SUPPL-4","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2015\\\/203085s004lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2015\\\/203085Orig1s004ltr.pdf\"}]","notes":">"},{"actionDate":"09\/13\/2013","submission":"SUPPL-3","supplementCategories":"Manufacturing (CMC)","inserts":"[]","notes":"> Label is not available on this site."},{"actionDate":"11\/10\/2014","submission":"SUPPL-2","supplementCategories":"Manufacturing (CMC)","inserts":"[]","notes":"> Label is not available on this site."},{"actionDate":"05\/29\/2013","submission":"SUPPL-1","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2013\\\/203085s001lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2013\\\/203085Orig1s001ltr.pdf\"}]","notes":">"}]
            [actionDate] => 2020-12-10
        )

)

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