PF PRISM CV FDA Approval NDA 203214

NDA 203214

PF PRISM CV

FDA Drug Application

Application #203214

Documents

Letter2013-11-20
Letter2014-02-25
Letter2014-03-28
Letter2014-05-08
Letter2015-02-17
Letter2015-12-23
Label2014-02-25
Label2014-04-01
Label2014-05-12
Review2015-09-25
Letter2012-11-07
Letter2013-11-12
Letter2015-06-24
Letter2016-02-09
Label2012-11-28
Label2013-11-22
Label2015-06-23
Review2012-12-18
Summary Review2012-12-18
Label2017-03-06
Label2017-08-24
Label2017-08-24
Label2017-12-15
Letter2017-12-15
Review2018-04-18
Label2018-05-30
Letter2018-05-31
Letter2018-08-20
Label2018-08-21
Label2018-10-19
Letter2018-10-23
Letter2019-07-26
Label2019-07-29
Letter2019-09-12
Label2019-08-30
Medication Guide2019-09-03
Review2019-10-31
Review2019-10-31
Label2019-12-13
Letter2019-12-13
Letter2020-09-29
Label2020-09-29
Medication Guide2020-09-29
Label2021-12-03
Medication Guide2021-12-03
Letter2021-12-06
Label2021-12-15
Medication Guide2021-12-15
Letter2021-12-16
Review2022-09-16

Application Sponsors

NDA 203214PF PRISM CV

Marketing Status

Prescription001
Prescription002

Application Products

001TABLET;ORALEQ 5MG BASE1XELJANZTOFACITINIB CITRATE
002TABLET;ORALEQ 10MG BASE1XELJANZTOFACITINIB CITRATE

FDA Submissions

TYPE 1; Type 1 - New Molecular EntityORIG1AP2012-11-06STANDARD
EFFICACY; EfficacySUPPL2AP2013-11-18STANDARD
EFFICACY; EfficacySUPPL4AP2014-02-21STANDARD
LABELING; LabelingSUPPL5AP2014-03-26STANDARD
REMS; REMSSUPPL6AP2013-11-08N/A
LABELING; LabelingSUPPL7AP2014-05-07STANDARD
REMS; REMSSUPPL8AP2015-02-11N/A
LABELING; LabelingSUPPL10AP2015-06-19STANDARD
LABELING; LabelingSUPPL11AP2015-12-22STANDARD
REMS; REMSSUPPL13AP2016-02-08N/A
EFFICACY; EfficacySUPPL14AP2017-08-22STANDARD
LABELING; LabelingSUPPL16AP2017-08-22STANDARD
EFFICACY; EfficacySUPPL17AP2017-12-14STANDARD
EFFICACY; EfficacySUPPL18AP2018-05-30STANDARD
LABELING; LabelingSUPPL20AP2018-10-18STANDARD
LABELING; LabelingSUPPL21AP2018-08-17STANDARD
LABELING; LabelingSUPPL23AP2019-08-30STANDARD
LABELING; LabelingSUPPL24AP2019-07-25STANDARD
LABELING; LabelingSUPPL25AP2019-12-12STANDARD
EFFICACY; EfficacySUPPL26AP2020-09-25PRIORITY
EFFICACY; EfficacySUPPL28AP2021-12-14STANDARD
LABELING; LabelingSUPPL31AP2021-12-02STANDARD

Submissions Property Types

ORIG1Null6
SUPPL2Null15
SUPPL4Null15
SUPPL5Null6
SUPPL6Null6
SUPPL7Null7
SUPPL8Null15
SUPPL10Null7
SUPPL11Null15
SUPPL13Null7
SUPPL14Null15
SUPPL16Null15
SUPPL17Null6
SUPPL18Null6
SUPPL20Null15
SUPPL21Null6
SUPPL23Null15
SUPPL24Null6
SUPPL25Null7
SUPPL26Null7
SUPPL28Null7
SUPPL31Null7

TE Codes

002PrescriptionAB

CDER Filings

PF PRISM CV
cder:Array
(
    [0] => Array
        (
            [ApplNo] => 203214
            [companyName] => PF PRISM CV
            [docInserts] => ["Medication Guide","https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2021\/203214s028,208246s013,213082s003lbl.pdf#page=66"]
            [products] => [{"drugName":"XELJANZ","activeIngredients":"TOFACITINIB CITRATE","strength":"EQ 5MG BASE","dosageForm":"TABLET;ORAL","marketingStatus":"Prescription","te":"None","rld":"Yes","rs":"No"},{"drugName":"XELJANZ","activeIngredients":"TOFACITINIB CITRATE","strength":"EQ 10MG BASE","dosageForm":"TABLET;ORAL","marketingStatus":"Prescription","te":"None","rld":"Yes","rs":"Yes"}]
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            [originalApprovals] => [{"actionDate":"11\/06\/2012","submission":"ORIG-1","actionType":"Approval","submissionClassification":"Type 1 - New Molecular Entity","reviewPriority":"STANDARD","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2012\\\/203214s000lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2012\\\/203214Orig1s000ltr.pdf\"},{\"name\":\"Review\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/nda\\\/2012\\\/203214Orig1s000TOC.cfm\"},{\"name\":\"Summary Review (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/nda\\\/2012\\\/203214Orig1s000SumR.pdf\"}]","notes":">"}]
            [supplements] => [{"actionDate":"12\/02\/2021","submission":"SUPPL-31","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2021\\\/203214s031lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2021\\\/203214Orig1s031ltr.pdf\"}]","notes":">"},{"actionDate":"12\/14\/2021","submission":"SUPPL-28","supplementCategories":"Efficacy-New Indication","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2021\\\/203214s028,208246s013,213082s003lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2021\\\/203214Orig1s028;208246Orig1s013;213082Orig1s003ltr.pdf\"}]","notes":">"},{"actionDate":"09\/25\/2020","submission":"SUPPL-26","supplementCategories":"Efficacy-New Patient 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(PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2018\\\/203214s020,208246s006lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2018\\\/203214Orig1s020,208246Orig1s006ltr.pdf\"}]","notes":">"},{"actionDate":"05\/30\/2018","submission":"SUPPL-18","supplementCategories":"Efficacy","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2018\\\/203214s018lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2018\\\/203214Orig1s018ltr.pdf\"},{\"name\":\"Review (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/nda\\\/2022\\\/203214Orig1s018.pdf\"}]","notes":">"},{"actionDate":"12\/14\/2017","submission":"SUPPL-17","supplementCategories":"Efficacy-New Indication","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2017\\\/203214s017,208246s003lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2017\\\/203214Orig1s017,208246ORig1s003ltr.pdf\"}]","notes":">"},{"actionDate":"08\/22\/2017","submission":"SUPPL-16","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2017\\\/203214s014s016,208246s001s002lbl.pdf\"}]","notes":">"},{"actionDate":"08\/22\/2017","submission":"SUPPL-14","supplementCategories":"Efficacy-Labeling Change With Clinical Data","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2017\\\/203214s014s016,208246s001s002lbl.pdf\"}]","notes":">"},{"actionDate":"02\/08\/2016","submission":"SUPPL-13","supplementCategories":"REMS-Modified","inserts":"[{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2016\\\/203214Orig1s013ltr.pdf\"},{\"name\":\"Review (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/nda\\\/2016\\\/203214Orig1s013.pdf\"}]","notes":"> Label is not available on this site."},{"actionDate":"12\/22\/2015","submission":"SUPPL-11","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2015\\\/203214s011lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2015\\\/203214Orig1s011ltr.pdf\"}]","notes":">"},{"actionDate":"06\/19\/2015","submission":"SUPPL-10","supplementCategories":"Labeling-Medication Guide, Labeling-Package Insert, REMS-Modified","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2015\\\/203214s010lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2015\\\/203214Orig1s010ltr.pdf\"}]","notes":">"},{"actionDate":"02\/11\/2015","submission":"SUPPL-8","supplementCategories":"REMS-Modified","inserts":"[{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2015\\\/203214Orig1s008ltr.pdf\"},{\"name\":\"Review (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/nda\\\/2015\\\/203214Orig1s008.pdf\"}]","notes":"> Label is not available on this site."},{"actionDate":"05\/07\/2014","submission":"SUPPL-7","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2014\\\/203214s007lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2014\\\/203214Orig1s007ltr.pdf\"}]","notes":">"},{"actionDate":"11\/08\/2013","submission":"SUPPL-6","supplementCategories":"REMS-Modified","inserts":"[{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2013\\\/203214Orig1s006ltr.pdf\"}]","notes":"> Label is not available on this site."},{"actionDate":"03\/26\/2014","submission":"SUPPL-5","supplementCategories":"Labeling-Medication Guide, Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2014\\\/203214s005lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2014\\\/203214Orig1s005ltr.pdf\"}]","notes":">"},{"actionDate":"02\/21\/2014","submission":"SUPPL-4","supplementCategories":"Efficacy-Labeling Change With Clinical Data, Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2014\\\/203214s004lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2014\\\/203214Orig1s004ltr.pdf\"},{\"name\":\"Review (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/nda\\\/2014\\\/203214Orig1s04.pdf\"}]","notes":">"},{"actionDate":"11\/18\/2013","submission":"SUPPL-2","supplementCategories":"Efficacy-Labeling Change With Clinical Data, Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2013\\\/203214s002lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2013\\\/203214Orig1s002ltr.pdf\"},{\"name\":\"Review (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/nda\\\/2013\\\/203214Orig1s002.pdf\"}]","notes":">"},{"actionDate":"05\/03\/2013","submission":"SUPPL-1","supplementCategories":"Manufacturing (CMC)","inserts":"[]","notes":"> Label is not available on this site."}]
            [actionDate] => 2021-12-14
        )

)

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