Application 212678

Type
ANDA
Sponsor
EDENBRIDGE PHARMS

Application Products#

Product, Drug, Ingredient table
ProductDrugIngredientFormStrengthReference drugReference standard
001BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEBISOPROLOL FUMARATE; HYDROCHLOROTHIAZIDETABLET;ORAL2.5MG;6.25MGNoNo
002BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEBISOPROLOL FUMARATE; HYDROCHLOROTHIAZIDETABLET;ORAL5MG;6.25MGNoNo
003BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEBISOPROLOL FUMARATE; HYDROCHLOROTHIAZIDETABLET;ORAL10MG;6.25MGNoNo

Source provenance: Browse the complete Orange Book source catalog · source snapshot 43.

Orange Book products#

Current product rows page 1 of 1 · 3 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A212678-001BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEBISOPROLOL FUMARATE; HYDROCHLOROTHIAZIDE2.5MG;6.25MGTABLET / ORALAB2020-07-09
A212678-002BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEBISOPROLOL FUMARATE; HYDROCHLOROTHIAZIDE5MG;6.25MGTABLET / ORALAB2020-07-09
A212678-003BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEBISOPROLOL FUMARATE; HYDROCHLOROTHIAZIDE10MG;6.25MGTABLET / ORALAB2020-07-09

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 3 matching rows.

Application-product, TE code table
Application-productTE code
A212678-001AB
A212678-002AB
A212678-003AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 117 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-09-14 22:38:342026-08A212678-001BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE2.5MG;6.25MGTABLET / ORALAB2020-07-0984e616aacf4f…
2026-09-14 22:38:342026-08A212678-002BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE5MG;6.25MGTABLET / ORALAB2020-07-0984e616aacf4f…
2026-09-14 22:38:342026-08A212678-003BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE10MG;6.25MGTABLET / ORALAB2020-07-0984e616aacf4f…
2026-08-18 06:07:402026-07A212678-001BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE2.5MG;6.25MGTABLET / ORALAB2020-07-09caaa826d4ba7…
2026-08-18 06:07:402026-07A212678-002BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE5MG;6.25MGTABLET / ORALAB2020-07-09caaa826d4ba7…
2026-08-18 06:07:402026-07A212678-003BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE10MG;6.25MGTABLET / ORALAB2020-07-09caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A212678-001BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE2.5MG;6.25MGTABLET / ORALAB2020-07-09011fe1cb6892…
2026-02-19 14:30 UTC2026-02A212678-002BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE5MG;6.25MGTABLET / ORALAB2020-07-09011fe1cb6892…
2026-02-19 14:30 UTC2026-02A212678-003BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE10MG;6.25MGTABLET / ORALAB2020-07-09011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212678-001BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE2.5MG;6.25MGTABLET / ORALAB2020-07-0931067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212678-002BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE5MG;6.25MGTABLET / ORALAB2020-07-0931067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212678-003BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE10MG;6.25MGTABLET / ORALAB2020-07-0931067a03dcf5…
2025-08-23 18:47 UTC2025-08A212678-001BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE2.5MG;6.25MGTABLET / ORALAB2020-07-096a471c1ec25d…
2025-08-23 18:47 UTC2025-08A212678-002BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE5MG;6.25MGTABLET / ORALAB2020-07-096a471c1ec25d…
2025-08-23 18:47 UTC2025-08A212678-003BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE10MG;6.25MGTABLET / ORALAB2020-07-096a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212678-001BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE2.5MG;6.25MGTABLET / ORALAB2020-07-09fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212678-002BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE5MG;6.25MGTABLET / ORALAB2020-07-09fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212678-003BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE10MG;6.25MGTABLET / ORALAB2020-07-09fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212678-001BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE2.5MG;6.25MGTABLET / ORALAB2020-07-09b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212678-002BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE5MG;6.25MGTABLET / ORALAB2020-07-09b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212678-003BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE10MG;6.25MGTABLET / ORALAB2020-07-09b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212678-001BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE2.5MG;6.25MGTABLET / ORALAB2020-07-0903ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212678-002BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE5MG;6.25MGTABLET / ORALAB2020-07-0903ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212678-003BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE10MG;6.25MGTABLET / ORALAB2020-07-0903ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212678-001BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE2.5MG;6.25MGTABLET / ORALAB2020-07-092680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212678-002BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE5MG;6.25MGTABLET / ORALAB2020-07-092680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212678-003BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE10MG;6.25MGTABLET / ORALAB2020-07-092680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212678-001BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE2.5MG;6.25MGTABLET / ORALAB2020-07-095bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212678-002BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE5MG;6.25MGTABLET / ORALAB2020-07-095bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212678-003BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE10MG;6.25MGTABLET / ORALAB2020-07-095bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212678-001BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE2.5MG;6.25MGTABLET / ORALAB2020-07-09d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212678-002BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE5MG;6.25MGTABLET / ORALAB2020-07-09d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212678-003BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE10MG;6.25MGTABLET / ORALAB2020-07-09d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A212678-001BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE2.5MG;6.25MGTABLET / ORALAB2020-07-09d06236e962d9…
2024-10-29 15:01 UTC2024-10A212678-002BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE5MG;6.25MGTABLET / ORALAB2020-07-09d06236e962d9…
2024-10-29 15:01 UTC2024-10A212678-003BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE10MG;6.25MGTABLET / ORALAB2020-07-09d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212678-001BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE2.5MG;6.25MGTABLET / ORALAB2020-07-0979d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212678-002BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE5MG;6.25MGTABLET / ORALAB2020-07-0979d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212678-003BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE10MG;6.25MGTABLET / ORALAB2020-07-0979d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212678-001BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE2.5MG;6.25MGTABLET / ORALAB2020-07-09301d65b070ca…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 3 · 117 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-09-14 22:38:342026-08A212678-001AB184e616aacf4f…
2026-09-14 22:38:342026-08A212678-002AB184e616aacf4f…
2026-09-14 22:38:342026-08A212678-003AB184e616aacf4f…
2026-08-18 06:07:402026-07A212678-001AB1caaa826d4ba7…
2026-08-18 06:07:402026-07A212678-002AB1caaa826d4ba7…
2026-08-18 06:07:402026-07A212678-003AB1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A212678-001AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A212678-002AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A212678-003AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212678-001AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212678-002AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212678-003AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08A212678-001AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A212678-002AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A212678-003AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212678-001AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212678-002AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212678-003AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212678-001AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212678-002AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212678-003AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212678-001AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212678-002AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212678-003AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212678-001AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212678-002AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212678-003AB12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212678-001AB15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212678-002AB15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212678-003AB15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212678-001AB1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212678-002AB1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212678-003AB1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A212678-001AB1d06236e962d9…
2024-10-29 15:01 UTC2024-10A212678-002AB1d06236e962d9…
2024-10-29 15:01 UTC2024-10A212678-003AB1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212678-001AB179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212678-002AB179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212678-003AB179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212678-001AB1301d65b070ca…

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 5 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Bisoprolol Fumarate and HydrochlorothiazideBISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEEdenbridge Pharmaceuticals LLC.295532b5-65c8-40c3-8d27-cfd334d128022026-08-28Warnings, Adverse reactionsExact identifier
application applno (ANDA): 212678
application number: ANDA212678
ndc (product): 42799-922
ndc (product): 42799-921
ndc (product): 42799-920
Bisoprolol Fumarate and HydrochlorothiazideBISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEBryant Ranch Prepack53221419-204c-40a2-9ec3-8e4b994dd39d2026-08-20Warnings, Adverse reactionsExact identifier
application applno (ANDA): 212678
application number: ANDA212678
ndc (product): 71335-1931
Bisoprolol Fumarate and HydrochlorothiazideBISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEA-S Medication Solutions12ba7eba-1874-41b6-aff5-7baba8b999842026-08-20Warnings, Adverse reactionsExact identifier
application applno (ANDA): 212678
application number: ANDA212678
ndc (product): 50090-5849
Bisoprolol Fumarate and HydrochlorothiazideBISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEBryant Ranch Prepack154cb1d2-9fb2-4c8d-90de-6a8062a8d1ba2026-08-19Warnings, Adverse reactionsExact identifier
application applno (ANDA): 212678
application number: ANDA212678
ndc (product): 71335-1769
Bisoprolol Fumarate and HydrochlorothiazideBISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEA-S Medication Solutions6b7f96c3-daf4-4029-a96b-baa37add0edb2025-09-05Warnings, Adverse reactionsExact identifier
application applno (ANDA): 212678
application number: ANDA212678
ndc (product): 50090-5905

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

NDC Listings For This Application#

NDC listings for this application page 1 of 1 · 19 matching rows.

NDC, Name, Nonproprietary name table
NDCNameNonproprietary nameLabelerMarketing categoryStatus
42799-920Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideEdenbridge Pharmaceuticals LLC.ANDACurrent
42799-920Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideEdenbridge Pharmaceuticals LLC.ANDACurrent
42799-920Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideEdenbridge Pharmaceuticals LLC.ANDACurrent
42799-920Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideEdenbridge Pharmaceuticals LLC.ANDACurrent
42799-921Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideEdenbridge Pharmaceuticals LLC.ANDACurrent
42799-921Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideEdenbridge Pharmaceuticals LLC.ANDACurrent
42799-921Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideEdenbridge Pharmaceuticals LLC.ANDACurrent
42799-921Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideEdenbridge Pharmaceuticals LLC.ANDACurrent
42799-922Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideEdenbridge Pharmaceuticals LLC.ANDACurrent
42799-922Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideEdenbridge Pharmaceuticals LLC.ANDACurrent
42799-922Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideEdenbridge Pharmaceuticals LLC.ANDACurrent
42799-922Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideEdenbridge Pharmaceuticals LLC.ANDACurrent
50090-5849Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideA-S Medication SolutionsANDACurrent
50090-5905Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideA-S Medication SolutionsANDACurrent
70518-3530Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideREMEDYREPACK INC.ANDACurrent
71335-1769Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideBryant Ranch PrepackANDACurrent
71335-1769Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideBryant Ranch PrepackANDACurrent
71335-1931Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideBryant Ranch PrepackANDACurrent
71335-1931Bisoprolol Fumarate and HydrochlorothiazideBisoprolol Fumarate and HydrochlorothiazideBryant Ranch PrepackANDACurrent