Application 213189

Type
NDA
Sponsor
ATHENEX INC

Application Products#

Product, Drug, Ingredient table
ProductDrugIngredientFormStrengthReference drugReference standard
001KLISYRITIRBANIBULINOINTMENT;TOPICAL1%YesNo

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N213189-001KLISYRITIRBANIBULIN1%OINTMENT / TOPICALRLD, RS2020-12-14

Orange Book patents#

Current patent rows page 1 of 1 · 6 matching rows.

Application-product, Patent, Expiration table
Application-productPatentExpirationUse codeCoverage / statusSubmission date
N213189-001103230012027-12-28Drug product2021-01-12
N213189-00178514702029-02-02U-3015Drug substance, Drug product2021-01-12
N213189-00173009312030-12-28Drug substance, Drug product2021-01-12
N213189-001106176932038-03-12U-30152021-01-12
N213189-001114977502038-03-12U-30152022-12-14
N213189-001106692362038-09-07Drug substance, Drug product2021-01-12

Orange Book exclusivity#

Current exclusivity rows page 1 of 1 · 1 matching rows.

Application-product, Exclusivity code, Expiration table
Application-productExclusivity codeExpiration
N213189-001D-1922027-06-07

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-14011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-1431067a03dcf5…
2025-08-23 18:47 UTC2025-08N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-146a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-14fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-14b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-1403ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-142680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-145bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-14d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-14d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-1479d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-14301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-141e350fbaab3a…
2024-05-31 18:47 UTC2024-05N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-148072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-145c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-145d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-144b0b4de00fa7…
2022-03-09 01:35 UTC2022-03N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-14bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-14782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-1487673890dc5c…
2021-03-12 10:30 UTC2021-03N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-145aa47cf7b7d7…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-146a51e52b5d6a…
2024-02-18 07:12 UTC2024-02N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-141c564ffb4f44…
2023-12-20 04:57 UTC2023-12N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-14ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-14a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-149b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-14a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-143f0d92c62455…
2023-05-13 08:27 UTC2023-05N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-14053a50430f4f…
2023-01-26 05:58 UTC2023-01N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-143bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-143a93d1ddd44b…
2022-10-28 04:53 UTC2022-10N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-14f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-14e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-14cb3db0bc1861…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06N213189-001KLISYRI1%OINTMENT / TOPICALRLD, RS2020-12-14a50c72e98297…

Observed Orange Book patent history#

Patent history page 1 of 7 · 265 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productPatentExpirationUse codeCoverage / statusSubmission dateSource SHA-256
2026-02-19 14:30 UTC2026-02N213189-001103230012027-12-28Drug product2021-01-12011fe1cb6892…
2026-02-19 14:30 UTC2026-02N213189-00178514702029-02-02U-3015Drug substance, Drug product2021-01-12011fe1cb6892…
2026-02-19 14:30 UTC2026-02N213189-00173009312030-12-28Drug substance, Drug product2021-01-12011fe1cb6892…
2026-02-19 14:30 UTC2026-02N213189-001106176932038-03-12U-30152021-01-12011fe1cb6892…
2026-02-19 14:30 UTC2026-02N213189-001114977502038-03-12U-30152022-12-14011fe1cb6892…
2026-02-19 14:30 UTC2026-02N213189-001106692362038-09-07Drug substance, Drug product2021-01-12011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N213189-00182367992025-12-28Drug substance, Drug product2021-01-1231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N213189-00189808902025-12-28Drug substance, Drug product2021-01-1231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N213189-001103230012027-12-28Drug product2021-01-1231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N213189-00178514702029-02-02U-3015Drug substance, Drug product2021-01-1231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N213189-00173009312030-12-28Drug substance, Drug product2021-01-1231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N213189-001106176932038-03-12U-30152021-01-1231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N213189-001114977502038-03-12U-30152022-12-1431067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N213189-001106692362038-09-07Drug substance, Drug product2021-01-1231067a03dcf5…
2025-08-23 18:47 UTC2025-08N213189-00182367992025-12-28Drug substance, Drug product2021-01-126a471c1ec25d…
2025-08-23 18:47 UTC2025-08N213189-00189808902025-12-28Drug substance, Drug product2021-01-126a471c1ec25d…
2025-08-23 18:47 UTC2025-08N213189-00173009312026-02-06Drug substance, Drug product2021-01-126a471c1ec25d…
2025-08-23 18:47 UTC2025-08N213189-001103230012027-12-28Drug product2021-01-126a471c1ec25d…
2025-08-23 18:47 UTC2025-08N213189-00178514702029-02-02U-3015Drug substance, Drug product2021-01-126a471c1ec25d…
2025-08-23 18:47 UTC2025-08N213189-001106176932038-03-12U-30152021-01-126a471c1ec25d…
2025-08-23 18:47 UTC2025-08N213189-001114977502038-03-12U-30152022-12-146a471c1ec25d…
2025-08-23 18:47 UTC2025-08N213189-001106692362038-09-07Drug substance, Drug product2021-01-126a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N213189-00182367992025-12-28Drug substance, Drug product2021-01-12fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N213189-00189808902025-12-28Drug substance, Drug product2021-01-12fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N213189-00173009312026-02-06Drug substance, Drug product2021-01-12fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N213189-001103230012027-12-28Drug product2021-01-12fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N213189-00178514702029-02-02U-3015Drug substance, Drug product2021-01-12fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N213189-001106176932038-03-12U-30152021-01-12fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N213189-001114977502038-03-12U-30152022-12-14fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N213189-001106692362038-09-07Drug substance, Drug product2021-01-12fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N213189-00182367992025-12-28Drug substance, Drug product2021-01-12b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N213189-00189808902025-12-28Drug substance, Drug product2021-01-12b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N213189-00173009312026-02-06Drug substance, Drug product2021-01-12b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N213189-001103230012027-12-28Drug product2021-01-12b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N213189-00178514702029-02-02U-3015Drug substance, Drug product2021-01-12b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N213189-001106176932038-03-12U-30152021-01-12b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N213189-001114977502038-03-12U-30152022-12-14b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N213189-001106692362038-09-07Drug substance, Drug product2021-01-12b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N213189-00182367992025-12-28Drug substance, Drug product2021-01-1203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N213189-00189808902025-12-28Drug substance, Drug product2021-01-1203ed91905a0d…

Observed Orange Book exclusivity history#

Exclusivity history page 1 of 2 · 45 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productExclusivity codeExpirationSource SHA-256
2026-02-19 14:30 UTC2026-02N213189-001D-1922027-06-07011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N213189-001NCE2025-12-1431067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N213189-001D-1922027-06-0731067a03dcf5…
2025-08-23 18:47 UTC2025-08N213189-001NCE2025-12-146a471c1ec25d…
2025-08-23 18:47 UTC2025-08N213189-001D-1922027-06-076a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N213189-001NCE2025-12-14fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N213189-001D-1922027-06-07fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N213189-001NCE2025-12-14b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N213189-001D-1922027-06-07b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N213189-001NCE2025-12-1403ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N213189-001D-1922027-06-0703ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N213189-001NCE2025-12-142680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N213189-001D-1922027-06-072680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N213189-001NCE2025-12-145bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N213189-001D-1922027-06-075bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N213189-001NCE2025-12-14d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N213189-001D-1922027-06-07d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N213189-001NCE2025-12-14d06236e962d9…
2024-10-29 15:01 UTC2024-10N213189-001D-1922027-06-07d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N213189-001NCE2025-12-1479d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N213189-001D-1922027-06-0779d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N213189-001NCE2025-12-14301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N213189-001NCE2025-12-141e350fbaab3a…
2024-05-31 18:47 UTC2024-05N213189-001NCE2025-12-148072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N213189-001NCE2025-12-145c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N213189-001NCE2025-12-145d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N213189-001NCE2025-12-144b0b4de00fa7…
2022-03-09 01:35 UTC2022-03N213189-001NCE2025-12-14bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N213189-001NCE2025-12-14782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N213189-001NCE2025-12-1487673890dc5c…
2021-03-12 10:30 UTC2021-03N213189-001NCE2025-12-145aa47cf7b7d7…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03N213189-001NCE2025-12-146a51e52b5d6a…
2024-02-18 07:12 UTC2024-02N213189-001NCE2025-12-141c564ffb4f44…
2023-12-20 04:57 UTC2023-12N213189-001NCE2025-12-14ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N213189-001NCE2025-12-14a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N213189-001NCE2025-12-149b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N213189-001NCE2025-12-14a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N213189-001NCE2025-12-143f0d92c62455…
2023-05-13 08:27 UTC2023-05N213189-001NCE2025-12-14053a50430f4f…
2023-01-26 05:58 UTC2023-01N213189-001NCE2025-12-143bdfa0b2c4d7…

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
KlisyriTIRBANIBULINAlmirall, LLC589c8de8-b773-4d47-b60c-48471806cccc2024-11-08Warnings, Adverse reactionsExact identifier
application applno (NDA): 213189
application number: NDA213189
ndc (product): 16110-391

NDC Listings For This Application#

NDC listings for this application page 1 of 1 · 3 matching rows.

NDC, Name, Nonproprietary name table
NDCNameNonproprietary nameLabelerMarketing categoryStatus
16110-391KlisyritirbanibulinAlmirall, LLCNDACurrent
16110-391KlisyritirbanibulinAlmirall, LLCNDACurrent
16110-391KlisyritirbanibulinAlmirall, LLCNDACurrent

Documents#

Document, Submission type, Date table
DocumentSubmission typeDate
78759SUPPL 2024-07-02
78758SUPPL 2024-07-02
78757SUPPL 2024-07-02
78775SUPPL 2024-06-12
78774SUPPL 2024-06-12
78773SUPPL 2024-06-12
65761ORIG2020-12-28
65598ORIG2020-12-15
65590ORIG2020-12-15