VETRISHIELD PLUS FLAVORED CHEWABLES (SMALL) UP TO 25 LBS- ivermectin/pyrantel tablet, chewable VETRISHIELD PLUS FLAVORED CHEWABLES (MEDIUM) 26 TO 50 LBS- ivermectin/pyrantel tablet, chewable VETRISHIELD PLUS FLAVORED CHEWABLES (LARGE) 51 TO 100 LBS- ivermectin/pyrantel tablet, chewable
VetriShield Plus Flavored Chewables by
Drug Labeling and Warnings
VetriShield Plus Flavored Chewables by is a Animal medication manufactured, distributed, or labeled by VetOne. Drug facts, warnings, and ingredients follow.
Drug Details [pdf]
- CAUTION:
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INDICATIONS:
For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense).
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DOSAGE:
VetriShield Plus (ivermectin/pyrantal pamoate) Flavored Chewables should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows:
Dog Weight Flavored Chewable Per Month Ivermectin Content Pyrantel Content Up to 25 lbs 1 68 mcg 57 mcg 26 to 50 lbs 1 136 mcg 114 mcg 51 to 100 lbs 1 272 mcg 227 mcg VetriShield Plus Flavored Chewables are recommended for dogs 6 weeks of age and older. For dogs over 100 lbs use the appropriate combination of these flavored chewables.
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ADMINISTRATION:
Remove only one flavored chewable at a time from the foil-backed blister card. Because most dogs find VetriShield Plus Flavored Chewables palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food or placed in the back of the dog's mouth for forced swallowing.
Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
VetriShield Plus Flavored Chewables should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog's first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog's last exposure to mosquitoes.
When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of VetriShield Plus Flavored Chewables must be given within a month (30 days) of the last dose of the former medication.
If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the flavored chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with VetriShield Plus Flavored Chewables and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.
Monthly treatment with VetriShield Plus Flavored Chewables also provides effective treatment and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.
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EFFICACY:
VetriShield Plus Flavored Chewables , given orally using the recommended dose and regimen, are effective against the tissue larval stage of D. immitis for a month (30 days) after infection and, as a result, prevent the development of the adult stage. VetriShield Plus Flavored Chewables are also effective against canine ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense).
ACCEPTABILITY: In a trial in client–owned dogs, VetriShield Plus Flavored Chewables were shown to be a palatable oral dosage form consumed at first offering by the majority of dogs.
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PRECAUTIONS:
All dogs should be tested for existing heartworm infection before starting treatment with VetriShield Plus Flavored Chewables, which are not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with VetriShield Plus Flavored Chewables.
While some microfilariae may be killed by the ivermectin in VetriShield Plus Flavored Chewables at the recommended dose level, VetriShield Plus Flavored Chewables are not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.
Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.
- STORAGE:
- WARNINGS:
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ADVERSE REACTIONS:
In clinical trials with ivermectin/pyrantel, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported following the use of ivermectin: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.
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SAFETY:
Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level of 6 mcg/kg) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. Ivermectin demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies. Results of these trials and bioequivalency studies, support the safety of ivermectin products in dogs, including Collies, when used as recommended.
Ivermectin/pyrantel has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been administered with ivermectin/pyrantel in a heartworm disease preventive program.
In one trial, where some pups had parvovirus, there was a marginal reduction in efficacy against intestinal nematodes, possibly due to a change in intestinal transit time.
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HOW SUPPLIED:
VetriShield Plus Flavored Chewables are available in three dosage strengths (See DOSAGE section) for dogs of different weights. Each strength comes in a box of 6 tablets, packed 10 boxes per display box.
ANADA 200-302, Approved by FDA.
Manufactured by: Virbac AH, Inc.
Fort Worth, TX 76137, USAFor technical assistance or to report adverse drug reactions, please call 1-800-338-3659.
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Package Label Principal Display Panel - 51-100lbs
FRONT PANEL
VetOne
VetriShield Plus
(ivermectin/pyrantel)
Flavored Chewables51-100 lbs.
Administer once a month to prevent heartworm disease and to treat and control ascarid and hookworm infections in dogs.
Each flavored chewable contains 272 mcg ivermectin and 227 mg pyrantel as pamoate salt.
CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.
Keep this and all drugs out of the reach of children.
Contains 6 Chewable Tablets
Approved by FDA under # ANADA 200-302.
BACK PANEL
VetOne
VetriShield Plus
(ivermectin/pyrantel)
Flavored ChewablesRecommended for dogs 51 to 100 lbs. body weight
Contains 6 Flavored ChewablesManufactured by: Virbac AH, Inc. Fort Worth, TX 76137, USA
For technical assistance or to report adverse drug reactions, please call 1-800-338-3659.
Approved by FDA under # ANADA 200-302.Store at 20ºC-25ºC (68ºF-77ºF), excursions permitted between 15ºC-30ºC (59ºF-86ºF). Protect product from light.
MADE IN THE USA
Distributed by: MWI
Boise, ID 83705
www.VetOne.net
Iss. 01/19
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Package Label Principal Display Panel - 26-50 lb
FRONT PANEL
VetOne
VetriShield Plus
(ivermectin/pyrantel)
Flavored Chewables26-50 lbs.
Administer once a month to prevent heartworm disease and to treat and control ascarid and hookworm infections in dogs.
Each flavored chewable contains 136 mcg ivermectin and 114 mg pyrantel as pamoate salt.
CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.
Keep this and all drugs out of the reach of children.
Contains 6 Chewable Tablets
Approved by FDA under # ANADA 200-302.
BACK PANEL
VetOne
VetriShield Plus
(ivermectin/pyrantel)
Flavored ChewablesRecommended for dogs 26-50 lbs. body weight
Contains 6 Flavored ChewablesManufactured by: Virbac AH, Inc. Fort Worth, TX 76137, USA
For technical assistance or to report adverse drug reactions, please call 1-800-338-3659
Approved by FDA under # ANADA 200-302.Store at 20ºC-25ºC (68ºF-77ºF), excursions permitted between 15ºC-30ºC (59ºF-86ºF). Protect product from light.
MADE IN THE USA
Distributed by: MWI
Boise, ID 83705
www.VetOne.net
Iss. 01/19
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Package Label Principal Display Panel - up to 25 lbs
FRONT PANEL
VetOne
VetriShield Plus
(ivermectin/pyrantel)
Flavored ChewablesUp to 25 lbs.
Administer once a month to prevent heartworm disease and to treat and control ascarid and hookworm infections in dogs.
Each flavored chewable contains 68 mcg ivermectin and 57 mg pyrantel as pamoate salt.
CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.
Keep this and all drugs out of the reach of children.
Contains 6 Chewable Tablets
Approved by FDA under # ANADA 200-302.
BACK PANEL
VetOne
VetriShield Plus
(ivermectin/pyrantel)
Flavored ChewablesRecommended for dogs Up to 25 lbs. body weight
Contains 6 Flavored ChewablesManufactured by: Virbac AH, Inc. Fort Worth, TX 76137, USA
For technical assistance or to report adverse drug reactions, please call 1-800-338-3659
Approved by FDA under # ANADA 200-302.Store at 20ºC-25ºC (68ºF-77ºF), excursions permitted between 15ºC-30ºC (59ºF-86ºF). Protect product from light.
MADE IN THE USA
Distributed by: MWI
Boise, ID 83705
www.VetOne.net
Iss. 01/19
-
INGREDIENTS AND APPEARANCE
VETRISHIELD PLUS FLAVORED CHEWABLES (SMALL) UP TO 25 LBS
ivermectin/pyrantel tablet, chewableProduct Information Product Type PRESCRIPTION ANIMAL DRUG Item Code (Source) NDC: 13985-951 Route of Administration oral Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength IVERMECTIN (UNII: 8883YP2R6D) (IVERMECTIN - UNII:8883YP2R6D) IVERMECTIN 0.068 mg PYRANTEL PAMOATE (UNII: 81BK194Z5M) (PYRANTEL - UNII:4QIH0N49E7) PYRANTEL .057 mg Inactive Ingredients Ingredient Name Strength WATER (UNII: 059QF0KO0R) Product Characteristics Color brown Score no score Shape ROUND Size 16mm Flavor Imprint Code Contains Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC: 13985-951-25 1 in 1 BOX 1 6 in 1 BLISTER PACK Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date ANADA ANADA200302 03/01/2019 VETRISHIELD PLUS FLAVORED CHEWABLES (MEDIUM) 26 TO 50 LBS
ivermectin/pyrantel tablet, chewableProduct Information Product Type PRESCRIPTION ANIMAL DRUG Item Code (Source) NDC: 13985-969 Route of Administration oral Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength IVERMECTIN (UNII: 8883YP2R6D) (IVERMECTIN - UNII:8883YP2R6D) IVERMECTIN .136 mg PYRANTEL PAMOATE (UNII: 81BK194Z5M) (PYRANTEL - UNII:4QIH0N49E7) PYRANTEL .114 mg Inactive Ingredients Ingredient Name Strength WATER (UNII: 059QF0KO0R) Product Characteristics Color brown Score no score Shape ROUND Size 16mm Flavor Imprint Code Contains Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC: 13985-969-50 1 in 1 BOX 1 6 in 1 BLISTER PACK Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date ANADA ANADA200302 03/01/2019 VETRISHIELD PLUS FLAVORED CHEWABLES (LARGE) 51 TO 100 LBS
ivermectin/pyrantel tablet, chewableProduct Information Product Type PRESCRIPTION ANIMAL DRUG Item Code (Source) NDC: 13985-970 Route of Administration oral Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength IVERMECTIN (UNII: 8883YP2R6D) (IVERMECTIN - UNII:8883YP2R6D) IVERMECTIN .272 mg PYRANTEL PAMOATE (UNII: 81BK194Z5M) (PYRANTEL - UNII:4QIH0N49E7) PYRANTEL .227 mg Inactive Ingredients Ingredient Name Strength WATER (UNII: 059QF0KO0R) Product Characteristics Color brown Score no score Shape ROUND Size 16mm Flavor Imprint Code Contains Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC: 13985-970-10 1 in 1 BOX 1 6 in 1 BLISTER PACK Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date ANADA ANADA200302 03/01/2019 Labeler - VetOne (019926120)
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