VetrImycin 100 by is a Animal medication manufactured, distributed, or labeled by MWI Veterinary Supply. Drug facts, warnings, and ingredients follow.
VETRIMYCIN 100- oxytetracycline hydrochloride injection, solution
MWI Veterinary Supply
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Vetrimycin™ 100 [oxytetracycline hydrochloride] is a sterile ready-to-use preparation containing 100 mg/mL oxytetracycline HCl, for administration of the broad spectrum antibiotic, oxytetracycline, by injection.
Oxytetracycline is effective against a wide range of gram-negative and gram-positive organisms that are pathogenic for cattle. The antibiotic is primarily bacteriostatic in effect, and is believed to exert its antimicrobial action by the inhibition of microbial protein synthesis. The antibiotic activity of oxytetracycline is not appreciably diminished in the presence of body fluids, serum or exudates. Since the drugs in the tetracycline class have similar antimicrobial spectra, organisms can develop cross resistance among them. Oxytetracycline is concentrated by the liver in the bile and excreted in the urine and feces at high concentrations and in a biologically active form.
Discontinue treatment with Vetrimycin™ 100 at least 22 days prior to slaughter of the animal. Not for use in lactating dairy animals. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.
Rapid intravenous administration may result in animal collapse. Oxytetracycline should be administered intravenously slowly over a period of at least 5 minutes.
If no improvement occurs within 24 to 48 hours, consult a veterinarian. Do not use the drug for more than 4 consecutive days. Use beyond 4 days or doses higher than maximum recommended dose may result in antibiotic tissue residues beyond the withdrawal period.
The improper or accidental injection of the drug outside of the vein will cause local tissue irritation manifested by temporary swelling and discoloration at the injection site.
Shortly after injection, treated animals may have a transient hemoglobinuria (darkened urine).
Consult with your veterinarian prior to administering this product in order to determine the proper treatment required in the event of an adverse reaction. At the first sign of any adverse reaction, discontinue use of product and seek the advice of your veterinarian. Some of the reactions may be attributed either to anaphylaxis (an allergic reaction) or to cardiovascular collapse of unknown cause.
Because bacteriostatic drugs interfere with the bactericidal action of penicillin, do not give oxytetracycline hydrochloride in conjunction with penicillin.
As with other antibiotics, use of this drug may result in over-growth of non-susceptible organisms. If any unusual symptoms occur or in the absence of a favorable response following treatment, discontinue use immediately and call a veterinarian.
Reports of adverse reactions associated with oxytetracycline administration include injection site swelling, restlessness, ataxia, trembling, swelling of eyelids, ears, muzzle, anus and vulva (or scrotum and sheath in males), respiratory abnormalities (labored breathing), frothing at the mouth, collapse and possibly death. Some of these reactions may be attributed either to anaphylaxis (an allergic reaction) or to cardiovascular collapse of unknown cause.
A great many of the pathogens involved in cattle diseases are known to be susceptible to oxytetracycline hydrochloride therapy. Many strains of organisms, however, have shown resistance to oxytetracycline. In the case of certain coliforms, streptococci and staphylococci, it may be advisable to conduct culture and sensitivity testing to determine susceptibility of the infecting organism to oxytetracycline. In this manner, the likelihood of successful treatment with Vetrimycin™ 100 solution can be determined in advance.
The use of Vetrimycin™ 100 is indicated in beef cattle, beef calves, non-lactating dairy cattle and dairy calves for treatment of the following disease conditions caused by one or more of the oxytetracycline-sensitive pathogens listed as follows:
Disease | Causative organism(s) which show
sensitivity to Vetrimycin™ 100 |
Bacterial Pneumonia and Shipping Fever complex associated with Pasteurella spp. | Pasteurella spp |
Bacterial Enteritis (scours) | Escherichia coli |
Necrotic Pododermatitis (Foot Rot) | Fusobacterium necrophorum |
Calf Diphtheria | Fusobacterium necrophorum |
Wooden Tongue | Actinobacillus lignieresi |
Wound Infections; Acute Metritis; Traumatic Injury | Caused by oxytetracycline- susceptible strains of streptococcal and staphylococcal organisms. |
Treat at the first clinical signs of disease.
The intravenous injection of 3 to 5 mg of oxytetracycline hydrochloride per pound of body weight per day (3 to 5 mL per 100 lbs body weight) is the recommended dosage.
Severe foot-rot and severe forms of the indicated diseases should be treated with 5 mg per pound of body weight. Surgical procedures may be indicated in some forms of foot-rot or other conditions.
In disease treatment, the daily dose of Vetrimycin™ 100 should be continued 24 to 48 hours following remission of disease symptoms; however, not to exceed a total of 4 consecutive days.
Equipment Recommended:
Thoroughly clean the needles, syringe and intravenous set and disinfect them by boiling in water for 20 minutes or by immersing in a suitable chemical disinfectant such as 70% alcohol for a period of not less than 30 minutes. Warm the bottle of medication to approximately body temperature and keep warm until used.
It is recommended that the correct dose be diluted in water for injection, sodium chloride injection or other suitable vehicle immediately prior to administration. Doses up to 50 mL may be diluted in 250 mL. Larger doses may be diluted in 500 mL of one of the diluents. Adverse reactions may be minimized and the drug dose can be better regulated by this method of administration.
Avoid touching the needle with the hands at all times.
In case of the syringe method of administration, disinfect the vial cap by wiping with 70% alcohol or other suitable antiseptic. Touching a sterile needle only by the hub, attach it to the syringe and push the plunger down the barrel to empty it of air. Puncture the rubber cap of the vial and withdraw the plunger upward in the syringe to draw up a volume of Vetrimycin™ 100, 100 mg/mL of about 5 mL more than is needed for injection. Withdraw from the vial and, pointing the needle upward, remove all air bubbles from the syringe by pushing the plunger upward to the volume required.
If the injection cannot be made immediately, the tip of the needle may be covered with cotton soaked in 70% alcohol to prevent contamination.
Refer to the following table for proper dosage according to body weight of the animal.
Weight of Animals, Lbs (Beef Cattle, Beef Calves, Non-Lactating Dairy Cattle, Dairy Calves) | Milligrams of Oxytetracycline Hydrochloride per 100 lbs of Body Weight per Day | Daily Dosage of Vetrimycin™ 100 |
50 | 300 – 500 mg | 1.5 – 2.5 mL |
100 | 300 – 500 mg | 3 – 5 mL |
200 | 300 – 500 mg | 6 – 10 mL |
300 | 300 – 500 mg | 9 – 15 mL |
400 | 300 – 500 mg | 12 – 20 mL |
500 | 300 – 500 mg | 15 – 25 mL |
600 | 300 – 500 mg | 18 – 30 mL |
800 | 300 – 500 mg | 24 – 40 mL |
1000 | 300 – 500 mg | 30 – 50 mL |
1200 | 300 – 500 mg | 36 – 60 mL |
1400 | 300 – 500 mg | 42 – 70 mL |
CAUTION: If no improvement is noted within 24 to 48 hours, consult a veterinarian. For intravenous use only.
Bubbles entering the bottle through the air tube or valve indicate the rate at which the medication is flowing. If the flow should stop, this means that the needle has slipped out of the vein (or is clogged) and the operation will have to be repeated. If using the syringe technique, pull back gently on the plunger: if blood flows into the syringe, the needle is in proper position. Depress the plunger slowly. If there is any resistance to the depression of the plunger, stop and repeat insertion procedure. The resistance indicates that either the needle is clogged or it has slipped out of the vein. With either method of administration, syringe or gravity flow, watch for any swelling under the skin near the needle, which would indicate that the medication is not going into the vein. Should this occur, it is best to try the vein on the opposite side of the neck. Sudden movement of the animal, especially twisting of the neck or raising or lowering the head, may sometimes cause the needle to slip out of the vein. To prevent this, tape the needle hub to the skin of the neck to hold the needle in position. Whenever there is any doubt as to the position of the needle, this should be checked in the following manner: Pinch off the intravenous tube to stop flow, disconnect the tube from the needle and re-apply pressure to the vein. Free flow of blood through the needle indicates that it is in proper position and the injection can then be continued. If using the syringe, gently pull back on the plunger. Blood should flow into the syringe.
The use of antibiotics, as with most medications used in the management of diseases, is based on accurate diagnosis and adequate treatment. When properly used in the treatment of diseases caused by oxytetracycline-susceptible organisms, animals usually show a noticeable improvement within 24 to 48 hours. If improvement does not occur within this period of time, the diagnosis and treatment of animal diseases should be carried out by a veterinarian. The use of professional veterinary and laboratory services can reduce treatment costs, time and needless losses. Good management, housing, sanitation and nutrition are essential in the care of animals and in the successful treatment of disease.
Vetrimycin™ 100 is available in 500 mL multidose vials containing 100 mg oxytetracycline hydrochloride per mL.
Store at controlled room temperature 20°-25°C (68°-77°F); excursions permitted 15°-30°C (59°-86°F). Protect from freezing.
For Use in Animals Only
RESTRICTED DRUG (California) - USE ONLY AS DIRECTED
NDC 13985-050-05
500 mL
VET one®
Vetrimycin™ 100
(Oxytetracycline Hydrochloride Injection)
Injection
(100 mg/mL)
ANTIBIOTIC
Multiple Dose Sterile Vial
Each mL contains 100 mg of oxytetracycline
hydrochloride.
For the treatment of disease in beef cattle,
beef calves, non-lactating dairy cattle,
and dairy calves.
Restricted Drug(s) (California)
Not for Human Use
Use Only as Directed
ANADA 200-452
Approved by FDA
V1 501020
Net Contents: 500 mL
NDC 13985-050-05
500 mL
VET one®
Vetrimycin™ 100
(Oxytetracycline Hydrochloride Injection)
Injection
100 mg/mL
ANTIBIOTIC
Multiple Dose Sterile Vial
FOR USE IN ANIMALS ONLY
RESTRICTED DRUG (CALIFORNIA)
USE ONLY AS DIRECTED
KEEP OUT OF REACH OF CHILDREN
ANADA 200-452
Approved by FDA
V1 501020
Net Contents: 500 mL
VETRIMYCIN 100
oxytetracycline hydrochloride injection, solution |
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Labeler - MWI Veterinary Supply (019926120) |