ADD ONE PACKET (250 MG) INTO AQUARIUM FOR EACH 15 GALLONS OF WATER TO BE TREATED. REPEAT IN 24 HOURS. IT IS SUGGESTED THAT A PARTIAL WATER CHANGE BE MADE BETWEEN TREATMENTS. WHILE DURATION OF TREATMENTS DEPENDS ON TYPE AND SEVERITY OF INFECTION, IT IS RECOMMENDED THAT EXTENDED MEDICATION BATHS CONTINUE FOR A MINIMUM OF 5 DAYS AND FOR NOT MORE THAN 10 DAYS. DISCONTINUE TREATMENT IF NO IMPROVEMENT IS NOTED WITHIN 5 DAYS. TO REMOVE HARMLESS YELLOW COLOR, CHANGE 20% OF WATER AND USE CHARCOAL FILTER UNTIL CLEAR.