A manual brachytherapy applicator specifically designed to be used in radiation therapy treatments of the bile duct. It is an individual device designed to facilitate manual placement, e.g., puncture, endoscopically guided or diagnostic imaging system guided placement, and removal of single or multiple radioactive sources at a treatment site within the bile duct. The device may be a fixed design or designed to accommodate individual patient source placement configurations and includes bile duct applicators such as hollow needles, tubes or catheters, used in manual brachytherapy applications.