A manual brachytherapy applicator specifically designed to be used in radiation therapy treatments of the bladder. It is an individual device designed to facilitate manual placement, e.g., endoscopically guided or diagnostic imaging system guided placement, and removal of single or multiple radioactive sources at a treatment site within the bladder. The device may be a fixed design or designed to accommodate individual patient source placement configurations and includes bladder applicators such as hollow needles, tubes or catheters, used in manual brachytherapy applications.