A device specifically designed to be used in radiation therapy treatments of the brain. It has individual or modular device configurations designed to facilitate manual placement, e.g., puncture, endoscopically guided placement or diagnostic imaging guided placement, and removal of single or multiple radioactive sources at a treatment site within the brain. The device may be a fixed design or designed to accommodate individual patient source placement configurations and includes brain applicators such as hollow needles, tubes or catheters, used in manual brachytherapy applications.