An in vitro diagnostic interpretive software program intended to be used in the assessment of risk of progression of chronic kidney disease (CKD). It uses specific algorithms to combine and correlate patient demographics, clinical observations, and the in vitro diagnostic results of the qualitative and/or quantitative detection of one or multiple chronic kidney disease biomarkers in a clinical specimen to establish an individual risk score that may be used to guide patient management to minimise progression to kidney failure and dialysis.