An assembly of devices designed to provide supersaturated oxygen (SSO2) therapy to targeted ischemic regions of a patient's coronary vasculature immediately following revasculization by means of percutaneous coronary intervention (PCI) with stenting. It is typically computer-controlled and consists of pumps, valves, detectors/sensors, clamps, patient/parameter monitors, alarms and an O2 gas source. The system controls a cartridge where a small amount of autologous blood is mixed with SSO2 solution (created by the system) producing oxygen-enriched hyperoxaemic blood which is infused via a dedicated catheter. It can have battery backup for short internal patient transport.