A sterile, bioabsorbable substance containing human-derived material [e.g., human serum albumin (HSA)] intended to be used for internal surgical applications to bond or seal cut, incised, or resected body tissues typically as an adjunct to standard methods of closure, seal leaks, and/or to achieve haemostasis. Disposable mixing devices/applicators may be included for preparation and application to anatomical sites. After application, this device cannot be reused.