A bioabsorbable substance containing human-derived material [e.g., human serum albumin (HSA)] intended to be used for internal surgical applications to bond or seal cut, incised, or resected body tissues typically as an adjunct to standard methods of closure, to seal leaks, and might in addition be intended to achieve haemostasis through tissue sealing. Disposable mixing devices/applicators may be included for preparation and application to anatomical sites. After application, this device cannot be reused.