AESKULISA® beta2-Glyco-Check is a solid phase enzyme immunoassay employing native beta2-glycoprotein I highly purified from human plasma for the combined quantitative and qualitative detection of IgA, IgG and IgM antibodies against beta2-glycoprotein I in human serum. Anti-beta2-glycoprotein I antibodies recognize specific epitopes on human beta2-glycoprotein I which are expressed only when beta2-glycoprotein I interacts with lipid membranes or when absorbed to other surfaces (e.g. microtiter plate). The assay is an aid in the diagnosis and risk of primary and secondary antiphospholipid syndrome (APS).
A collection of reagents and other associated materials intended to be used for the qualitative and/or quantitative detection of one or multiple classes of antibodies to beta-2-glycoprotein I in a clinical specimen, using an enzyme immunoassay (EIA) method.